{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:43:05Z","timestamp":1769233385718,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP) Brazil","award":["02\/13863-2"],"award-info":[{"award-number":["02\/13863-2"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP) Brazil","award":["07\/03336-9"],"award-info":[{"award-number":["07\/03336-9"]}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Toxinas (INCTTOX) Brazil","award":["2008\/57898-0"],"award-info":[{"award-number":["2008\/57898-0"]}]},{"name":"C.T. is recipient of CNPq-PQ","award":["306099\/2008-0"],"award-info":[{"award-number":["306099\/2008-0"]}]},{"name":"V.M. is recipient of Pos doctoral fellowship from FAPESP\u2014Brazil","award":["07\/03337-5"],"award-info":[{"award-number":["07\/03337-5"]}]},{"name":"P.C.M.C.S. is recipient of MS fellowship from FAPESP\u2014Brazil","award":["06\/58341-4"],"award-info":[{"award-number":["06\/58341-4"]}]},{"name":"M.A.R.V. is recipient of Pos doctoral fellowship from FAPESP\u2014Brazil","award":["10\/07630-1"],"award-info":[{"award-number":["10\/07630-1"]}]},{"name":"R.C. is recipient of CNPq and FAPESP"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.ejphar.2013.01.061","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T03:16:48Z","timestamp":1360898208000},"page":"68-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages"],"prefix":"10.1016","volume":"708","author":[{"given":"Vanessa","family":"Moreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pollyana Cristina Maggio","family":"de Castro Souto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aur\u00e9lio","family":"Ramirez Vinolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mar\u00eda Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Curi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.01.061_bib1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0024-3205(98)00031-9","article-title":"Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-\u03baB","volume":"62","author":"Abate","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2013.01.061_bib2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/01.STR.31.6.1377","article-title":"Mechanism of ATP-induced [Ca(2+)](i) mobilization in rat basilar smooth muscle cells","volume":"31","author":"Aoki","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2013.01.061_bib500","doi-asserted-by":"crossref","first-page":"30527","DOI":"10.1074\/jbc.M008481200","article-title":"Functional coupling between secretory and cytosolic phospholipase A(2) modulates tumor necrosis factor-alpha-and interleukin-1 beta-induced NF-kappa B activation","volume":"276","author":"Anthonsen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib501","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1073\/pnas.95.14.7951","article-title":"Functional coupling between secretory phospholipase A2 and cyclooxygenase\u20132 and its regulation by cytosolic group IV phospholipase A2","volume":"95","author":"Balsinde","year":"1998","journal-title":"Proc. Natl. Acad. USA."},{"key":"10.1016\/j.ejphar.2013.01.061_bib3","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.4049\/jimmunol.165.5.2790","article-title":"Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytes","volume":"165","author":"Bidgood","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2013.01.061_bib4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib5","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1194\/jlr.R800033-JLR200","article-title":"Phospholipase A2 structure\/function, mechanism, and signaling","volume":"50","author":"Burke","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2013.01.061_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/abbi.1998.0853","article-title":"Immunochemical characterization and role in toxic activities of region 115\u2013129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom","volume":"358","author":"Calder\u00f3n","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2013.01.061_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0041-0101(03)00007-2","article-title":"Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants","volume":"41","author":"Chacur","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib503","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0898-6568(02)00144-4","article-title":"Phospholipase A2 isoforms: a perspective","volume":"15","author":"Chakraborti","year":"2003","journal-title":"Cell Signal."},{"key":"10.1016\/j.ejphar.2013.01.061_bib8","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0041-0101(98)00107-X","article-title":"Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of snake Bothrops asper","volume":"36","author":"Chaves","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-5793(97)01377-X","article-title":"Involvement of NF-\u03baB in regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages","volume":"418","author":"D\u2019Aquisto","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2013.01.061_bib10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/1381612043453144","article-title":"Cyclooxygenase enzymes: regulation and function","volume":"10","author":"Fitzpatrick","year":"2004","journal-title":"Curr. Pharm."},{"key":"10.1016\/j.ejphar.2013.01.061_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.toxicon.2004.06.004","article-title":"Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2","volume":"44","author":"Gambero","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib12","doi-asserted-by":"crossref","first-page":"24153","DOI":"10.1074\/jbc.M300424200","volume":"278","author":"Han","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1074\/jbc.273.1.606","article-title":"Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1","volume":"273","author":"Hern\u00e1ndez","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/bbrc.1999.0832","article-title":"Secretory phospholipase A2 induces phospholipase Cgamma-1 activation and Ca2+ mobilization in the human astrocytoma cell line 1321N1 by a mechanism independent of its catalytic activity","volume":"260","author":"Hern\u00e1ndez","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2013.01.061_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/hh0102.102978","article-title":"Secretory phospholipase A2 elicits proinflammatory changes and upregulates the surface expression of fas ligand in monocytic cells: potencial relevance for atherogenesis","volume":"90","author":"Hern\u00e1ndez","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2013.01.061_bib16","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/neuonc\/noq078","article-title":"Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation","volume":"12","author":"Hern\u00e1ndez","year":"2010","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ejphar.2013.01.061_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.300.2.367","article-title":"Cyclooxygenase-2\u201410 years later","volume":"300","author":"Hinz","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2013.01.061_bib18","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.bbamcr.2009.10.004","article-title":"Inflammatory protein sPLA(2)-IIA abrogates TNFalpha-induced apoptosis in human astroglioma cells: crucial role of ERK","volume":"1793","author":"Ibeas","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2013.01.061_bib20","doi-asserted-by":"crossref","first-page":"F291","DOI":"10.1152\/ajprenal.2001.280.2.F291","article-title":"Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells","volume":"280","author":"Kifor","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.ejphar.2013.01.061_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0014-5793(97)00373-6","article-title":"Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line","volume":"407","author":"Kinoshita","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2013.01.061_bib22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00011-006-0083-z","article-title":"Cloning of cyclooxygenase-1b (putative COX-3) in mouse","volume":"55","author":"Kis","year":"2006","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejphar.2013.01.061_bib24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.toxicon.2003.11.008","article-title":"An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action","volume":"42","author":"Lomonte","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0041-0101(89)90039-1","article-title":"A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)","volume":"27","author":"Lomonte","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib26","first-page":"647","article-title":"Phospholipases A2 from Viperidae snake venoms: how do they induce skeletal muscle damage?","volume":"58","author":"Lomonte","year":"2011","journal-title":"Acta Chim. Slov."},{"key":"10.1016\/j.ejphar.2013.01.061_bib27","doi-asserted-by":"crossref","first-page":"29867","DOI":"10.1016\/S0021-9258(18)43961-0","article-title":"Neutralizing interaction between heparins and myotoxin II, a Lys-49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling","volume":"269","author":"Lomonte","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib28","doi-asserted-by":"crossref","first-page":"15840","DOI":"10.1074\/jbc.M011313200","article-title":"Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha","volume":"276","author":"Martin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.toxicon.2008.06.012","article-title":"Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases","volume":"52","author":"Moreira","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib31","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1074\/jbc.274.5.3103","article-title":"Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways","volume":"274","author":"Murakami","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib32","doi-asserted-by":"crossref","first-page":"32783","DOI":"10.1074\/jbc.M003505200","article-title":"Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2","volume":"275","author":"Murakami","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/oxfordjournals.jbchem.a003101","article-title":"Phospholipase A2","volume":"131","author":"Murakami","year":"2002","journal-title":"J. Biochem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib35","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.4049\/jimmunol.170.4.2093","article-title":"Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression","volume":"170","author":"Park","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2013.01.061_bib36","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1006\/bbrc.1997.7722","article-title":"Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages","volume":"240","author":"Park","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2013.01.061_bib37","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1074\/jbc.272.6.3231","article-title":"Prostaglandin synthase-1 and prostaglandin synthase-2 are coupled to distinct phospholipases for the generation of prostaglandin D2 in activated mast cells","volume":"272","author":"Reddy","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib38","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.2174\/092986705774462860","article-title":"Inhibitors of secretory phospholipase A2 group IIA","volume":"12","author":"Reid","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib39","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1046\/j.1471-4159.1996.67020662.x","article-title":"Seizure activity results in a rapid induction of nuclear factor-kappa B in adult but not juvenile rat limbic structures","volume":"67","author":"Rong","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib40","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jss.2010.05.035","article-title":"Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline","volume":"171","author":"Schabbauer","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2013.01.061_bib41","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jss.2010.05.035","article-title":"Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline","volume":"171","author":"Schaeffer","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2013.01.061_bib42","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1091-255X(01)80102-5","article-title":"PI-3\u2032 kinase and NF-kappaB cross-signaling in human pancreatic cancer cells","volume":"5","author":"Shah","year":"2001","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.ejphar.2013.01.061_bib44","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.4049\/jimmunol.161.9.5008","article-title":"Induction of cyclooxygenase-2 by secretory phospholipases A2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by independent of their enzymatic functions","volume":"161","author":"Tada","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2013.01.061_bib45","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/S0021-9258(17)42159-4","article-title":"Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages","volume":"269","author":"Takayama","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","article-title":"Phosphorylation of NF-\u03baB and I\u03baB proteins: implications in cancer and inflammation","volume":"30","author":"Viatour","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2013.01.061_bib47","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jnutbio.2010.07.009","article-title":"Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils","volume":"22","author":"Vinolo","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2013.01.061_bib48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1042\/bj3620089","article-title":"Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis","volume":"362","author":"Ward","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2013.01.061_bib49","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1096\/fj.03-0645rev","article-title":"Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic","volume":"18","author":"Warner","year":"2004","journal-title":"FASEB J."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2013.01.061_bib50","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1388-1981(00)00107-4","article-title":"Calcium-independent phospholipase A(2): structure and function","volume":"1488","author":"Winstead","year":"2000","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.ejphar.2013.01.061_bib53","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.toxicon.2004.11.004","article-title":"Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity","volume":"45","author":"Zuliani","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2013.01.061_bib54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.toxicon.2004.11.004","article-title":"Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholiases A2","volume":"45","author":"Zuliani","year":"2005","journal-title":"Toxicon"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913000927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913000927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:44:59Z","timestamp":1720572299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913000927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":50,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0014299913000927"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.01.061","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.01.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}