{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:10:55Z","timestamp":1792080655418,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-3","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.ejphar.2013.02.022","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T01:05:15Z","timestamp":1361927115000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations"],"prefix":"10.1016","volume":"704","author":[{"given":"Louise V.","family":"Rice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Bax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria J.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Walton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Deakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Solari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Begg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.02.022_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1748-1716.1983.tb00026.x","article-title":"Serotonin induced release of acetylcholine from neurons in the bronchial smooth muscle of the rat","volume":"117","author":"Aas","year":"1983","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2013.02.022_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2332\/allergolint.55.387","article-title":"Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells","volume":"55","author":"Akabane","year":"2006","journal-title":"Allergol. Int."},{"key":"10.1016\/j.ejphar.2013.02.022_bib3","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.jaci.2012.01.070","article-title":"CRACM\/Orai ion channel expression and function in human lung mast cells","volume":"129","author":"Ashmole","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib4","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1084\/jem.20101597","article-title":"Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma","volume":"207","author":"Byun","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2013.02.022_bib5","doi-asserted-by":"crossref","first-page":"19265","DOI":"10.1074\/jbc.M801535200","article-title":"Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry","volume":"283","author":"DeHaven","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.02.022_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0306-3623(97)00377-7","article-title":"Contractile responses of proximal and distal trachea segments isolated from rats subjected to immunological stimulation: role of connective tissue mast cells","volume":"30","author":"de Lima","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ceca.2012.11.005","article-title":"The action of novel CRAC channel blockers is affected by the Orai pore geometry","volume":"53","author":"Derler","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2013.02.022_bib8","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1021\/jm990615a","article-title":"3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator","volume":"43","author":"Djuric","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2013.02.022_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/sj.bjp.0702304","article-title":"Anaphylactic bronchoconstriction in BP2 mice: interactions between serotonin and acetylcholine","volume":"126","author":"Eum","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.02.022_bib11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1165\/ajrcmb\/8.5.518","article-title":"Effect of salbutamol, fenoterol, and sodium cromoglycate on the release of heparin from sensitized human lung fragments challenged with Dermatophagoides pteronyssinus allergen","volume":"8","author":"Green","year":"1993","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib12","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1128\/MCB.00360-08","article-title":"Hair loss and defective T- and B-cell function in mice lacking ORAI1","volume":"28","author":"Gwack","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ejphar.2013.02.022_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/138920111793937943","article-title":"Pharmacological modulation of diacylglycerol-sensitive TRPC3\/6\/7 channels","volume":"12","author":"Harteneck","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000139285","article-title":"Effect of hydrocortisone and disodium cromoglycate on mast cell-mediator release induced by substance P","volume":"50","author":"Heiman","year":"1995","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2013.02.022_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1113\/jphysiol.1993.sp019681","article-title":"Calcium release-activated calcium current in rat mast cells","volume":"465","author":"Hoth","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0014-2999(97)81929-2","article-title":"Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro","volume":"338","author":"Joos","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0145-2126(02)00343-0","article-title":"Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma\/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI","volume":"27","author":"Kirshenbaum","year":"2003","journal-title":"Leuk. Res."},{"key":"10.1016\/j.ejphar.2013.02.022_bib19","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx","volume":"15","author":"Liou","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib20","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1073\/pnas.1013285108","article-title":"ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis","volume":"108","author":"Maul-Pavicic","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejphar.2013.02.022_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1615\/CritRevImmunol.v29.i2.40","article-title":"Regulation of Ca2+ signaling with particular focus on mast cells","volume":"29","author":"Ma","year":"2009","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib22","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jaci.2009.10.007","article-title":"ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia","volume":"124","author":"McCarl","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.2007.147249","article-title":"Orai1 subunit stoichiometry of the mammalian CRAC channel pore","volume":"586","author":"Mignen","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib24","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1213\/01.ane.0000260266.34430.e1","article-title":"The effects of fentanyl on the contractile response of ovalbumin-sensitized rat trachea","volume":"104","author":"Nishioka","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.02.022_bib25","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1152\/physrev.00057.2003","article-title":"Store-operated calcium channels","volume":"85","author":"Parekh","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2013.02.022_bib26","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa0900082","article-title":"STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity","volume":"360","author":"Picard","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2013.02.022_bib27","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in TLR4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2013.02.022_bib28","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000236471","article-title":"Late-phase reaction in asthma: basic mechanisms","volume":"101","author":"Pradalier","year":"1993","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature05122","article-title":"Orai1 is an essential pore subunit of the CRAC channel","volume":"443","author":"Prakriya","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.02.022_bib32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1085\/jgp.106.3.415","article-title":"Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes","volume":"106","author":"Ross","year":"1995","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib31","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1124\/mol.105.021154","article-title":"A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity","volume":"69","author":"Takezawa","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib33","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1161\/ATVBAHA.111.243907","article-title":"Antithrombotic potential of blockers of store-operated calcium channels in platelets","volume":"32","author":"van Kruchten","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.f.220","article-title":"Calcium signaling in immune cells","volume":"10","author":"Vig","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1213\/01.ane.0000229853.01875.60","article-title":"Propofol attenuates ovalbumin-induced smooth muscle contraction of the sensitized rat trachea: inhibition of serotonergic and cholinergic signaling","volume":"103","author":"Yamaguchi","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.02.022_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2007.01.012","article-title":"YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models","volume":"560","author":"Yoshino","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.022_bib37","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00011-004-1309-6","article-title":"Inhibitory effects of budesonide, desloratadine and dexamethasone on cytokine release from human mast cell line (HMC-1)","volume":"53","author":"Zhao","year":"2004","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejphar.2013.02.022_bib38","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1074\/jbc.M309297200","article-title":"Potent inhibition of Ca2+ release-activated Ca2+channels and T-lymphocyte activation by the pyrazole derivative BTP2","volume":"279","author":"Zitt","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913001180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913001180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T11:55:51Z","timestamp":1539863751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913001180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":38,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0014299913001180"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.022","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}