{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:38:40Z","timestamp":1791106720438,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ejphar.2013.02.042","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T11:36:29Z","timestamp":1363174589000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Strontium ranelate prevents the deleterious action of advanced glycation endproducts on osteoblastic cells via calcium channel activation"],"prefix":"10.1016","volume":"706","author":[{"given":"Juan Manuel","family":"Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Silvina","family":"Molinuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sedlinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f3n","family":"Schurman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Cortizo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Desmond","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.02.042_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bone.2006.09.011","article-title":"Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways","volume":"40","author":"Alikhani","year":"2007","journal-title":"Bone"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2013.02.042_bib2","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1007\/s00198-004-1809-9","article-title":"Strontium ranelate: a novel mode of action leading to renewed bone quality","volume":"16","author":"Ammann","year":"2005","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ejphar.2013.02.042_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1196\/annals.1333.077","article-title":"Advanced glycation end product receptor-mediated cellular dysfunction","volume":"1043","author":"Bierhaus","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2013.02.042_bib4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/978-1-4020-6191-2_21","article-title":"Calcium signalling and calcium transport in bone disease","volume":"45","author":"Blair","year":"2007","journal-title":"Subcell. Biochem"},{"key":"10.1016\/j.ejphar.2013.02.042_bib5","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s10856-011-4379-3","article-title":"Osteopenic bone cell response to strontium-substituted hydroxyapatite","volume":"22","author":"Boanini","year":"2011","journal-title":"J. Mater. Sci.\u2014Mater. Med."},{"key":"10.1016\/j.ejphar.2013.02.042_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"Suppl. 3","key":"10.1016\/j.ejphar.2013.02.042_bib7","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1007\/s00198-002-1343-6","article-title":"Is the calcium receptor a molecular target for the actions of strontium on bone?","volume":"14","author":"Brown","year":"2003","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ejphar.2013.02.042_bib8","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.bone.2008.02.010","article-title":"Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms","volume":"42","author":"Caverzasio","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2013.02.042_bib9","first-page":"2","article-title":"Effect of surface topography of collagen scaffolds on cytotoxicity and osteoblast differentiation","author":"Cortizo","year":"2012","journal-title":"J. Biomater. Tissue Eng."},{"key":"10.1016\/j.ejphar.2013.02.042_bib10","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.bcp.2007.04.020","article-title":"The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation","volume":"74","author":"Chattopadhyay","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib11","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1359\/jbmr.070321","article-title":"Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins","volume":"22","author":"Choudhary","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 4","key":"10.1016\/j.ejphar.2013.02.042_bib12","first-page":"iv17","article-title":"Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength","volume":"47","author":"Fonseca","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ejphar.2013.02.042_bib13","first-page":"650","article-title":"Advanced glycation end products affect growth and function of osteoblasts","volume":"29","author":"Franke","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib14","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1582-4934.2008.00673.x","article-title":"Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate","volume":"13","author":"Fromigue","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2013.02.042_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2008.10.031","article-title":"Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells","volume":"600","author":"Gangoiti","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/diab.44.7.775","article-title":"Bone loss and bone turnover in diabetes","volume":"44","author":"Krakauer","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2013.02.042_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-\u03b1\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ejphar.2013.02.042_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(76)90018-0","article-title":"Correlation between structural transformation and cleavage of the major head protein of T4 bacteriophage","volume":"7","author":"Laemmli","year":"1976","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2013.02.042_bib19","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1359\/jbmr.070508","article-title":"Further insights in the mechanisms of interleukin-1\u03b2 stimulation of osteoprotegerin in osteoblast-like cells","volume":"22","author":"Lambert","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2013.02.042_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.02.042_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","article-title":"What old means to bone","volume":"21","author":"Manolagas","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"issue":"1813","key":"10.1016\/j.ejphar.2013.02.042_bib22","first-page":"1815","article-title":"Effective doses for strontium ranelate","volume":"19","author":"Marie","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ejphar.2013.02.042_bib23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1124\/mi.10.5.7","article-title":"Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology","volume":"10","author":"Marie","year":"2010","journal-title":"Mol. Interv."},{"key":"10.1016\/j.ejphar.2013.02.042_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1006816223292","article-title":"Effects of advanced glycation end-products on the proliferation and differentiation of osteoblast-like cells","volume":"170","author":"McCarthy","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2013.02.042_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2121-2-16","article-title":"Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress","volume":"2","author":"McCarthy","year":"2001","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s005920050144","article-title":"Advanced glycation endproduct-specific receptors in rat and mouse osteoblast-like cells: regulation with stages of differentiation","volume":"36","author":"McCarthy","year":"1999","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s005920170007","article-title":"Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development","volume":"38","author":"McCarthy","year":"2001","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:MCBI.0000049128.71095.ac","article-title":"AGE-R3\/galectin-3 expression in osteoblast-like cells: regulation by AGEs","volume":"266","author":"Mercer","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2013.02.042_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1359\/jbmr.090732","article-title":"Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies","volume":"25","author":"Molinuevo","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2013.02.042_bib30","first-page":"257","article-title":"Role of the receptor for advanced glycation end products (RAGE) in inflammation","volume":"51","author":"Mosquera","year":"2010","journal-title":"Invest. Clin."},{"key":"10.1016\/j.ejphar.2013.02.042_bib31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jbmr.5650070613","article-title":"Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development","volume":"7","author":"Quarles","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2013.02.042_bib32","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1365-2362.2011.02545.x","article-title":"Effects of inflammatory and anti-inflammatory cytokines on the bone","volume":"41","author":"Schett","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2013.02.042_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1055\/s-2007-992786","article-title":"Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells","volume":"116","author":"Schurman","year":"2008","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.ejphar.2013.02.042_bib34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1359\/jbmr.1997.12.3.439","article-title":"Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells","volume":"12","author":"Takagi","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2013.02.042_bib35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s00125-005-1786-3","article-title":"Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk","volume":"48","author":"Vestergaard","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2013.02.042_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2796.2002.00932.x","article-title":"Diabetes and advanced glycation endproducts","volume":"251","author":"Vlassara","year":"2002","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ejphar.2013.02.042_bib37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrendo.2011.74","article-title":"AGE restriction in diabetes mellitus: a paradigm shift","volume":"7","author":"Vlassara","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ejphar.2013.02.042_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4239\/wjd.v2.i3.41","article-title":"Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms","volume":"2","author":"Wongdee","year":"2011","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.ejphar.2013.02.042_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbrc.2007.01.120","article-title":"Induction of a program gene expression during osteoblast differentiation with strontium ranelate","volume":"355","author":"Zhu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913001519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913001519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T08:25:17Z","timestamp":1644567917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913001519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":39,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0014299913001519"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.042","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Strontium ranelate prevents the deleterious action of advanced glycation endproducts on osteoblastic cells via calcium channel activation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}