{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:23:23Z","timestamp":1760898203257,"version":"3.44.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ejphar.2013.02.044","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T07:33:54Z","timestamp":1363160034000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Azithromycin: A new concept in adjuvant treatment of periodontitis"],"prefix":"10.1016","volume":"705","author":[{"given":"Francisco Wilker Mustafa Gomes","family":"Muniz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Carvalho","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosimary","family":"de Sousa Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M\u00f4nica Studart Mendes","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elisabete Amaral","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Souza","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.02.044_bib1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.mi.49.100195.003431","article-title":"Microbial biofilms","volume":"49","author":"Costerton","year":"1995","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1902\/jop.2007.060247","article-title":"Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin","volume":"78","author":"Gomi","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib3","first-page":"592","article-title":"Overview of patient compliance with medication dosing: a literature review","volume":"6","author":"Greenberg","year":"1984","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejphar.2013.02.044_bib4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1600-051X.2008.01254.x","article-title":"Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial","volume":"35","author":"Haas","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1399-302X.2007.00403.x","article-title":"Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis","volume":"23","author":"Haffajee","year":"2008","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal disease","author":"Haffajee","year":"1994","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.ejphar.2013.02.044_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1902\/annals.2003.8.1.115","article-title":"Systemic anti-infective periodontal therapy. A systematic review","volume":"8","author":"Haffajee","year":"2003","journal-title":"Ann. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1600-051X.2006.01040.x","article-title":"Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results","volume":"34","author":"Haffajee","year":"2007","journal-title":"J. Clin. Periodontol."},{"issue":"Suppl","key":"10.1016\/j.ejphar.2013.02.044_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","article-title":"A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients","volume":"29","author":"Herrera","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/0022034510368650","article-title":"Azythomycin decreases crevicular fluid volume and mediator content","volume":"89","author":"Ho","year":"2010","journal-title":"J. Dent. Res."},{"issue":"suppl","key":"10.1016\/j.ejphar.2013.02.044_bib12","first-page":"1","article-title":"Dental plaque as a biofilm and a microbial community\u2013implications for health and disease","volume":"6","author":"Marsh","year":"2006","journal-title":"BMC Oral Health."},{"key":"10.1016\/j.ejphar.2013.02.044_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1902\/jop.2005.76.3.426","article-title":"Clinical response of Azithromycin as an adjunct to non-surgical periodontal therapy in smokers","volume":"76","author":"Mascarenhas","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib14","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/BF01975835","article-title":"Phagocytic uptake and transport of azithromycin","volume":"10","author":"McDonald","year":"1991","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejphar.2013.02.044_bib15","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1902\/jop.2010.100163","article-title":"Effects of irrigation with an antiseptic and oral administration of azithromycin on bacteremia caused by scaling and root planing","volume":"81","author":"Morozumi","year":"2010","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib16","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1034\/j.1600-051X.2002.290810.x","article-title":"In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics","volume":"29","author":"M\u00fcller","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib17","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1600-051X.2010.01607.x","article-title":"Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalis-associated periodontitis: a pilot study","volume":"37","author":"Oteo","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib18","first-page":"35","article-title":"Efectos de uma terapia sist\u00e9mica con azitromicina em el tratamento de la periodontites cr\u00f3nica","volume":"16","author":"Plaza","year":"2003","journal-title":"Av. Periodon. Implantol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib19","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1902\/jop.2008.070589","article-title":"Clinical and microbiologic effects of subgingivally delivered 0.5% azithromycin in the treatment of chronic periodontitis","volume":"79","author":"Pradeep","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib21","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1902\/jop.1975.46.9.522","article-title":"Results following three modality of periodontal therapy","volume":"46","author":"Ramfjord","year":"1975","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib22","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1128\/AAC.31.12.1939","article-title":"Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms","volume":"31","author":"Retsema","year":"1987","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.ejphar.2013.02.044_bib23","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1600-051X.2011.01766.x","article-title":"Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: a randomized placebo-controlled clinical trial","volume":"38","author":"Sampaio","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib24","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/0002-9343(91)90394-D","article-title":"Tissue-directed pharmacokinetics","volume":"91","author":"Schentag","year":"1991","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2013.02.044_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1034\/j.1600-051x.2002.290109.x","article-title":"A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: clinical results","volume":"29","author":"Smith","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-051X.1998.tb02414.x","article-title":"Microbiota of health, gingivitis and initial periodontitis","volume":"25","author":"Tanner","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1099\/00222615-44-2-79","article-title":"Susceptibility of oral bacterial biofilms to antimicrobial agents","volume":"44","author":"Wilson","year":"1996","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ejphar.2013.02.044_bib28","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1902\/jop.2009.090067","article-title":"One-stage full-mouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered Azithromycin","volume":"80","author":"Yashima","year":"2009","journal-title":"J. Periodontol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913001532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913001532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:18:04Z","timestamp":1757974684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913001532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":26,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0014299913001532"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.044","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Azithromycin: A new concept in adjuvant treatment of periodontitis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}