{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:46:24Z","timestamp":1791564384805,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2010-0028646"],"award-info":[{"award-number":["2010-0028646"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2011-0006724"],"award-info":[{"award-number":["2011-0006724"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.ejphar.2013.03.026","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T07:39:54Z","timestamp":1364197194000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia\/reperfusion injury via heme oxygenase-1 induction"],"prefix":"10.1016","volume":"707","author":[{"given":"Juhyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Woo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Mee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.03.026_bib1","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.2174\/1381612033453730","article-title":"Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway","volume":"9","author":"Alam","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2013.03.026_bib2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0026-895X(25)09068-6","article-title":"Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist","volume":"41","author":"Alkondon","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"Determination of glutathione and glutathione disulfide in biological samples","volume":"113","author":"Anderson","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1165\/ajrcmb.13.4.7546768","article-title":"Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation","volume":"13","author":"Camhi","year":"1995","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.510230315","article-title":"The role of cytokine networks in the local liver injury following hepatic ischemia\/reperfusion in the rat","volume":"23","author":"Colletti","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2013.03.026_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1472-6890-6-3","article-title":"Protection of early phase hepatic ischemia\u2013reperfusion injury by cholinergic agonists","volume":"6","author":"Crockett","year":"2006","journal-title":"BMC Clin. Pathol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/1044-7431(92)90043-2","article-title":"Methyl lycaconitine: a novel nicotinic antagonist","volume":"3","author":"Drasdo","year":"1992","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.ejphar.2013.03.026_bib9","doi-asserted-by":"crossref","first-page":"27018","DOI":"10.1074\/jbc.M103658200","article-title":"Cobalt induces heme oxygenase-1 expression by a hypoxia-inducible factor-independent mechanism in Chinese hamster ovary cells: regulation by Nrf2 and MafG transcription factors","volume":"276","author":"Gong","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.03.026_bib10","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.24501","article-title":"Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice","volume":"54","author":"Huang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2013.03.026_bib11","doi-asserted-by":"crossref","first-page":"G1083","DOI":"10.1152\/ajpgi.00568.2005","article-title":"Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia\u2013reperfusion and other acute inflammatory conditions","volume":"290","author":"Jaeschke","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib12","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1096\/fasebj.4.15.2253850","article-title":"Neutrophils contribute to ischemia\/reperfusion injury in rat liver in vivo","volume":"4","author":"Jaeschke","year":"1990","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2013.03.026_bib13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1023\/B:PHAM.0000022413.43212.cf","article-title":"Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway","volume":"21","author":"Jeong","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejphar.2013.03.026_bib14","doi-asserted-by":"crossref","first-page":"24735","DOI":"10.1074\/jbc.M110.204859","article-title":"Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages","volume":"286","author":"Joe","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.03.026_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1034\/j.1600-6143.2001.10205.x","article-title":"Heme oxygenase-1 overexpression protects rat livers from ischemia\/reperfusion injury with extended cold preservation","volume":"1","author":"Kato","year":"2001","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.ejphar.2013.03.026_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/mt.2009.285","article-title":"Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury","volume":"18","author":"Ke","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejphar.2013.03.026_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02980056","article-title":"Role of Kupffer cells in the vasoregulatory gene expression during hepatic ischemia\/reperfusion","volume":"27","author":"Kim","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejphar.2013.03.026_bib18","doi-asserted-by":"crossref","first-page":"G201","DOI":"10.1152\/ajpgi.00186.2006","article-title":"Hepatocyte NF-kappaB activation is hepatoprotective during ischemia\u2013reperfusion injury and is augmented by ischemic hypothermia","volume":"292","author":"Kuboki","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/01.TP.0000153160.82975.86","article-title":"The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation","volume":"79","author":"Land","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.ejphar.2013.03.026_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1600-0714.2007.00616.x","article-title":"Differential induction of heme oxygenase-1 against nicotine-induced cytotoxicity via the PI3K, MAPK, and NF-kappa B pathways in immortalized and malignant human oral keratinocytes","volume":"37","author":"Lee","year":"2008","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib21","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1902\/jop.2009.090098","article-title":"Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells","volume":"80","author":"Lee","year":"2009","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/SHK.0b013e31827aa1f6","volume":"39","author":"Li","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2013.03.026_bib23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0076-6879(96)68049-5","article-title":"Carbon monoxide and nitric oxide homology: differential modulation of heme oxygenases in brain and detection of protein and activity","volume":"268","author":"Maines","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.ejphar.2013.03.026_bib24","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","article-title":"Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB J"},{"key":"10.1016\/j.ejphar.2013.03.026_bib25","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1074\/jbc.M705606200","article-title":"JunD protects the liver from ischemia\/reperfusion injury by dampening AP-1 transcriptional activation","volume":"283","author":"Marden","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.03.026_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3858\/emm.2008.40.1.11","article-title":"Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia","volume":"40","author":"Moon","year":"2008","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib27","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.freeradbiomed.2010.09.017","article-title":"Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via alpha7 nicotinic receptors linked to a Jak2\/Akt\/HO-1 signaling pathway","volume":"49","author":"Parada","year":"2010","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","article-title":"Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling","volume":"14","author":"Parrish","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib29","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/01.CCM.0000259381.56526.96","article-title":"Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis","volume":"35","author":"Pavlov","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-0031-1282046","article-title":"The multiple functions of heme oxygenase-1 in the liver","volume":"50","author":"Sass","year":"2012","journal-title":"Z. Gastroenterol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2527\/2003.8151237x","article-title":"The toxicity and kinetics of larkspur alkaloid, methyllycaconitine, in mice","volume":"81","author":"Stegelmeier","year":"2003","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.ejphar.2013.03.026_bib32","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2013.03.026_bib33","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.03.026_bib34","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1089\/ars.2010.3555","article-title":"Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction","volume":"14","author":"Tsoyi","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.ejphar.2013.03.026_bib35","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1084\/jem.20070247","article-title":"HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling","volume":"204","author":"Tsung","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuint.2009.09.011","article-title":"Cholinergic protection via alpha7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroinflammation","volume":"56","author":"Tyagi","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2013.03.026_bib37","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1053\/j.gastro.2006.02.022","article-title":"The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice","volume":"130","author":"van Westerloo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2013.03.026_bib38","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1086\/430323","article-title":"The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis","volume":"191","author":"van Westerloo","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejphar.2013.03.026_bib39","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2013.03.026_bib40","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.03.026_bib41","doi-asserted-by":"crossref","first-page":"F162","DOI":"10.1152\/ajprenal.00438.2010","article-title":"Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury","volume":"301","author":"Wei","year":"2011","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib42","doi-asserted-by":"crossref","first-page":"e2026","DOI":"10.1371\/journal.pone.0002026","article-title":"Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia\u2013reperfusion","volume":"3","author":"Wu","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2013.03.026_bib43","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1038\/sj.onc.1208656","article-title":"Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells","volume":"24","author":"Xu","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2013.03.026_bib44","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1128\/MCB.25.14.5933-5946.2005","article-title":"Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1","volume":"25","author":"Yang","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2013.03.026_bib45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ki.2008.94","article-title":"Cholinergic agonists attenuate renal ischemia\u2013reperfusion injury in rats","volume":"74","author":"Yeboah","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2013.03.026_bib46","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1089\/ars.2009.2873","article-title":"Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats","volume":"13","author":"Yun","year":"2010","journal-title":"Antioxid. Redox Signal"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913002161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913002161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:17:03Z","timestamp":1757974623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913002161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":46,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0014299913002161"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.03.026","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia\/reperfusion injury via heme oxygenase-1 induction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}