{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:12:06Z","timestamp":1788919926740,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.ejphar.2013.07.033","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T15:46:43Z","timestamp":1375199203000},"page":"469-474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone"],"prefix":"10.1016","volume":"718","author":[{"given":"Beyzagul","family":"Polat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Cadirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmecit","family":"Albayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Karakus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Bayir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habip","family":"Bilen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba Nurcan","family":"Yuksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.07.033_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000223695","article-title":"Secondary osteoporosis","volume":"16","author":"Ahmed","year":"2009","journal-title":"Endocrine Development"},{"key":"10.1016\/j.ejphar.2013.07.033_bib2","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1359\/jbmr.1999.14.12.2137","article-title":"Evidence for a pathogenic role of nitric oxide in inflammation-induced osteoporosis","volume":"14","author":"Armour","year":"1999","journal-title":"Journal of Bone and Mineral Research"},{"issue":"Suppl.","key":"10.1016\/j.ejphar.2013.07.033_bib3","first-page":"OL1835","article-title":"Prevention of bone loss by Panax ginseng in a rat model of inflammation-induced bone loss","volume":"59","author":"Avsar","year":"2013","journal-title":"Cellular and Molecular Biology (Noisy-le-Grand)"},{"key":"10.1016\/j.ejphar.2013.07.033_bib4","first-page":"570","article-title":"Lipoic acid\u2014the drug of the future?","volume":"57","author":"Bilska","year":"2005","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.ejphar.2013.07.033_bib5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/bja\/77.1.110","article-title":"Sepsis and cytokines: current status","volume":"77","author":"Blackwell","year":"1996","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.ejphar.2013.07.033_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00062752-200105000-00001","article-title":"Aging and proinflammatory cytokines","volume":"8","author":"Bruunsgaard","year":"2001","journal-title":"Current Opinion in Hematology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1083\/jcb.145.3.527","article-title":"The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts","volume":"145","author":"Burgess","year":"1999","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/SHK.0b013e3181c3cf0e","article-title":"Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats","volume":"33","author":"Cadirci","year":"2010","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2013.07.033_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.archger.2004.09.001","article-title":"Prooxidant activities of alpha-lipoic acid on oxidative protein damage in the aging rat heart muscle","volume":"40","author":"Cakatay","year":"2005","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"10.1016\/j.ejphar.2013.07.033_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jep.2011.09.030","article-title":"A traditional Chinese herbal preparation, Er-Zhi-Wan, prevent ovariectomy-induced osteoporosis in rats","volume":"138","author":"Cheng","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib11","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/rheumatology\/ken385","article-title":"Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis","volume":"47","author":"Choi","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ejphar.2013.07.033_bib12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/PL00000629","article-title":"Anti-interleukin-1 and anti-tumor necrosis factor-alpha synergistically inhibit adjuvant arthritis in Lewis rats","volume":"57","author":"Feige","year":"2000","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.ejphar.2013.07.033_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.ejphar.2013.07.033_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0169-6009(92)90809-R","article-title":"On the rat model of human osteopenias and osteoporoses","volume":"18","author":"Frost","year":"1992","journal-title":"Bone and Mineral"},{"key":"10.1016\/j.ejphar.2013.07.033_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2007.09.027","article-title":"Protective effects of amlodipine and lacidipine on ovariectomy-induced bone loss in rats","volume":"579","author":"Halici","year":"2008","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.4158\/EP.9.6.544","article-title":"American Association of Clinical Endocrinologists medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003","volume":"9","author":"Hodgson","year":"2003","journal-title":"Endocrine Practice"},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2013.07.033_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bj3170059","article-title":"Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins","volume":"317","author":"Hunter","year":"1996","journal-title":"Biochemical Journal"},{"issue":"Pt 3","key":"10.1016\/j.ejphar.2013.07.033_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1042\/bj3000723","article-title":"Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation","volume":"300","author":"Hunter","year":"1994","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.ejphar.2013.07.033_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1017\/S0007114507876227","article-title":"Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats","volume":"100","author":"Huong","year":"2008","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.ejphar.2013.07.033_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/GME.0b013e31827c44bd","article-title":"Denosumab: an antifracture therapy for postmenopausal women with osteoporosis","volume":"20","author":"Jiang","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.ejphar.2013.07.033_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1621100","article-title":"Increased osteoclast development after estrogen loss: mediation by interleukin-6","volume":"257","author":"Jilka","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2013.07.033_bib22","first-page":"500","article-title":"Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6","volume":"23","author":"Jilka","year":"1995","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0169-6009(91)90124-I","article-title":"The ovariectomized rat model of postmenopausal bone loss","volume":"15","author":"Kalu","year":"1991","journal-title":"Bone and Mineral"},{"key":"10.1016\/j.ejphar.2013.07.033_bib24","doi-asserted-by":"crossref","first-page":"H224","DOI":"10.1111\/j.1750-3841.2012.02920.x","article-title":"Alpha-lipoic acid protects against indomethacin-induced gastric oxidative toxicity by modulating antioxidant system","volume":"77","author":"Kaplan","year":"2012","journal-title":"Journal of Food Science"},{"key":"10.1016\/j.ejphar.2013.07.033_bib25","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.freeradbiomed.2005.10.066","article-title":"Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha","volume":"40","author":"Kim","year":"2006","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.ejphar.2013.07.033_bib26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1677\/joe.1.05995","article-title":"Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand\/osteoprotegerin ratio in human bone marrow stromal cells","volume":"185","author":"Koh","year":"2005","journal-title":"Journal of Endocrinology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib27","article-title":"NELL-1 injection maintains long bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model","author":"Kwak","year":"2012","journal-title":"Tissue Engineering Part A"},{"key":"10.1016\/j.ejphar.2013.07.033_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2013.07.033_bib29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2013.07.033_bib30","first-page":"424","article-title":"The laboratory rat as an animal model for osteoporosis research","volume":"58","author":"Lelovas","year":"2008","journal-title":"Comparative Medicine"},{"key":"10.1016\/j.ejphar.2013.07.033_bib31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.mehy.2010.09.023","article-title":"Inflammaging: the driving force in osteoporosis?","volume":"76","author":"Lencel","year":"2011","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.ejphar.2013.07.033_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF01623180","article-title":"The growing problem of osteoporosis","volume":"2","author":"Lindsay","year":"1992","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.ejphar.2013.07.033_bib33","first-page":"w13624","article-title":"The future of osteoporosis treatment\u2014a research update","volume":"142","author":"Lippuner","year":"2012","journal-title":"Swiss Medical Weekly"},{"key":"10.1016\/j.ejphar.2013.07.033_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archinte.169.1.25","article-title":"Osteoporosis case manager for patients with hip fractures: results of a cost-effectiveness analysis conducted alongside a randomized trial","volume":"169","author":"Majumdar","year":"2009","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.ejphar.2013.07.033_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/endo-115-1-50","article-title":"Inflammation-mediated osteopenia in the rat: a new animal model for pathological loss of bone mass","volume":"115","author":"Minne","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0891-5849(01)00610-4","article-title":"Oxidative stress modulates osteoblastic differentiation of vascular and bone cells","volume":"31","author":"Mody","year":"2001","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.ejphar.2013.07.033_bib37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/taap.2002.9437","article-title":"Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid","volume":"182","author":"Moini","year":"2002","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.ejphar.2013.07.033_bib38","unstructured":"National Osteoporosis Foundation, Washington D.C., 2010. Clinician's Guide to Prevention and Treatment of Osteoporosis."},{"key":"10.1016\/j.ejphar.2013.07.033_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0007114510003107","article-title":"alpha-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations","volume":"105","author":"Odabasoglu","year":"2011","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.ejphar.2013.07.033_bib40","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis","volume":"11","author":"Pacifici","year":"1996","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.ejphar.2013.07.033_bib41","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/j.1460-2075.1994.tb06368.x","article-title":"Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion","volume":"13","author":"Poli","year":"1994","journal-title":"EMBO Journal"},{"key":"10.1016\/j.ejphar.2013.07.033_bib42","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1017\/S0007114507659030","article-title":"Black Lucques olives prevented bone loss caused by ovariectomy and talc granulomatosis in rats","volume":"97","author":"Puel","year":"2007","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.ejphar.2013.07.033_bib43","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/jbmr.5650100708","article-title":"Nitric oxide: a cytokine-induced regulator of bone resorption","volume":"10","author":"Ralston","year":"1995","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.ejphar.2013.07.033_bib44","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1073\/pnas.87.12.4473","article-title":"Osteopontin\u2014a possible anchor of osteoclasts to bone","volume":"87","author":"Reinholt","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of United States of America"},{"key":"10.1016\/j.ejphar.2013.07.033_bib45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S8756-3282(01)00682-2","article-title":"Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis","volume":"30","author":"Romas","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2013.07.033_bib46","article-title":"Interaction(s) between essential fatty acids, eicosanoids, cytokines, growth factors and free radicals: relevance to new therapeutic strategies in rheumatoid arthritis and other collagen vascular diseases","volume":"44","author":"Un","year":"1991","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"key":"10.1016\/j.ejphar.2013.07.033_bib47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00774-005-0672-x","article-title":"High-turnover osteoporosis is induced by cyclosporin A in rats","volume":"24","author":"Wada","year":"2006","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"10.1016\/j.ejphar.2013.07.033_bib48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0163-7827(00)00016-3","article-title":"Bioactive fatty acids: role in bone biology and bone cell function","volume":"40","author":"Watkins","year":"2001","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.ejphar.2013.07.033_bib49","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1172\/JCI28550","article-title":"Estrogen deficiency and bone loss: an inflammatory tale","volume":"116","author":"Weitzmann","year":"2006","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.ejphar.2013.07.033_bib50","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1359\/jbmr.2000.15.11.2178","article-title":"Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand","volume":"15","author":"Xu","year":"2000","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.ejphar.2013.07.033_bib51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1423-0127-19-28","article-title":"The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues","volume":"19","author":"Zupan","year":"2012","journal-title":"Journal of Biomedical Science"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913005554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913005554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T15:39:13Z","timestamp":1646235553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913005554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":51,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0014299913005554"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.07.033","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}