{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:53:23Z","timestamp":1793692403408,"version":"4.5.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.ejphar.2013.07.034","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T22:01:31Z","timestamp":1375221691000},"page":"318-324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Ozone oxidative postconditioning ameliorates joint damage and decreases pro-inflammatory cytokine levels and oxidative stress in PG\/PS-induced arthritis in rats"],"prefix":"10.1016","volume":"714","author":[{"given":"Jaqueline Dranguet","family":"Vaillant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mallok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Viebahn-H\u00e4nsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Fahmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Barber\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv\u00e1n","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Sonia Le\u00f3n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.07.034_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1478-3231.2004.00885.x","article-title":"Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion","volume":"24","author":"Ajamieh","year":"2004","journal-title":"Liver International"},{"key":"10.1016\/j.ejphar.2013.07.034_bib2","first-page":"85","article-title":"Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis","volume":"60","author":"Alivernini","year":"2008","journal-title":"Reumatismo"},{"key":"10.1016\/j.ejphar.2013.07.034_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/08916930801929021","article-title":"Molecular mechanisms of autoimmunity","volume":"41","author":"Atassi","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ejphar.2013.07.034_bib4","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1186\/ar3424","article-title":"Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis","volume":"13","author":"Biniecka","year":"2011","journal-title":"Arthritis Research and Therapy"},{"key":"10.1016\/j.ejphar.2013.07.034_bib5","series-title":"Biochemica Information. A Revised Biochemical Reference Source. Enzymes for Routine","first-page":"80","author":"Boehringer_Mannheim","year":"1987"},{"key":"10.1016\/j.ejphar.2013.07.034_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-2999(94)00672-T","article-title":"Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase","volume":"273","author":"Connor","year":"1995","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.ejphar.2013.07.034_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1313.001","article-title":"Posttranslational modifications of self-antigens","volume":"1050","author":"Doyle","year":"2005","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.ejphar.2013.07.034_bib8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/rheumatology\/34.9.801","article-title":"The involvement of the gut in the pathogenesis of inflammatory synovitis","volume":"34","author":"Gaston","year":"1995","journal-title":"British Journal of Rheumatology"},{"key":"10.1016\/j.ejphar.2013.07.034_bib9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1089\/ars.2007.1569","article-title":"Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies","volume":"9","author":"Gelderman","year":"2007","journal-title":"Antioxidants and Redox Signaling"},{"key":"10.1016\/j.ejphar.2013.07.034_bib10","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/rheumatology\/keh283","article-title":"Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain","volume":"43","author":"Gonzalez-Gay","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2013.07.034_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/meth.1995.1011","article-title":"Determination of nitrate and nitrite in biological samples using bacterial nitrate reductase coupled with the griess reaction","volume":"7","author":"Granger","year":"1995","journal-title":"Methods"},{"key":"10.1016\/j.ejphar.2013.07.034_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.imlet.2006.04.011","article-title":"Molecular and cellular basis of rheumatoid joint destruction","volume":"106","author":"Karouzakis","year":"2006","journal-title":"Immunology Letters"},{"key":"10.1016\/j.ejphar.2013.07.034_bib13","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1002\/art.11424","article-title":"Splenectomy attenuates streptococcal cell wall-induced arthritis and alters leukocyte activation","volume":"48","author":"Kimpel","year":"2003","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.ejphar.2013.07.034_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.ejphar.2013.07.034_bib15","first-page":"39","article-title":"Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia\/reperfusion","volume":"21","author":"Leon Fernandez","year":"2008","journal-title":"Transplant International"},{"key":"10.1016\/j.ejphar.2013.07.034_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/09629359890983","article-title":"Ozone oxidative preconditioning: a protection against cellular damage by free radicals","volume":"7","author":"Leon","year":"1998","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.ejphar.2013.07.034_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF03402168","article-title":"Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis","volume":"8","author":"Mabley","year":"2002","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.ejphar.2013.07.034_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/bbrc.1998.8203","article-title":"Increased pentosidine, an advanced glycation end product, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory markers","volume":"244","author":"Miyata","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.ejphar.2013.07.034_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.imlet.2008.02.009","article-title":"Nitric oxide production of T lymphocytes is increased in rheumatoid arthritis","volume":"118","author":"Nagy","year":"2008","journal-title":"Immunology Letters"},{"key":"10.1016\/j.ejphar.2013.07.034_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2007.04.013","article-title":"Nitric oxide, chronic inflammation and autoimmunity","volume":"111","author":"Nagy","year":"2007","journal-title":"Immunology Letters"},{"key":"10.1016\/j.ejphar.2013.07.034_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.ejphar.2013.07.034_bib22","first-page":"2529","article-title":"Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages","volume":"30","author":"Pham","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.ejphar.2013.07.034_bib23","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1172\/JCI118292","article-title":"Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides","volume":"96","author":"Sakurai","year":"1995","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.ejphar.2013.07.034_bib24","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1002\/1529-0131(200112)44:12<2909::AID-ART479>3.0.CO;2-#","article-title":"Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic","volume":"44","author":"Salvemini","year":"2001","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.ejphar.2013.07.034_bib25","first-page":"1173","article-title":"Distribution of protein nitrotyrosine in synovial tissues of patients with rheumatoid arthritis and osteoarthritis","volume":"30","author":"Sandhu","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.ejphar.2013.07.034_bib26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/rheumatology\/41.7.793","article-title":"The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century","volume":"41","author":"Symmons","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2013.07.034_bib27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0024-3205(96)00349-9","article-title":"Advanced glycation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's disease","volume":"59","author":"Thome","year":"1996","journal-title":"Life Sciences"},{"key":"10.1016\/j.ejphar.2013.07.034_bib28","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1073\/pnas.130511497","article-title":"Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption","volume":"97","author":"van\u2032t Hof","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ejphar.2013.07.034_bib29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/ar95","article-title":"Citrullination: a small change for a protein with great consequences for rheumatoid arthritis","volume":"2","author":"van Venrooij","year":"2000","journal-title":"Arthritis Research"},{"key":"10.1016\/j.ejphar.2013.07.034_bib30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2474-11-83","article-title":"Increased concentration of two different advanced glycation end-products detected by enzyme immunoassays with new monoclonal antibodies in sera of patients with rheumatoid arthritis","volume":"11","author":"Vytasek","year":"2010","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1016\/j.ejphar.2013.07.034_bib31","doi-asserted-by":"crossref","first-page":"32357","DOI":"10.1074\/jbc.M005638200","article-title":"Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade","volume":"275","author":"Woo","year":"2000","journal-title":"Journal of Biological Chemistry"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913005566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913005566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T21:42:27Z","timestamp":1563572547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913005566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":31,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0014299913005566"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.07.034","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ozone oxidative postconditioning ameliorates joint damage and decreases pro-inflammatory cytokine levels and oxidative stress in PG\/PS-induced arthritis in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}