{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:12:23Z","timestamp":1768687943800,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Deanship of Scientific Research (DSR), King Abdulaziz University","award":["1432\/130\/110"],"award-info":[{"award-number":["1432\/130\/110"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.ejphar.2013.08.009","type":"journal-article","created":{"date-parts":[[2013,9,8]],"date-time":"2013-09-08T00:15:23Z","timestamp":1378599323000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity"],"prefix":"10.1016","volume":"718","author":[{"given":"Ahmed M.","family":"Al-Abd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad A.","family":"Al-Abbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gihan F.","family":"Asaad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf B.","family":"Abdel-Naim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.08.009_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jconrel.2009.10.003","article-title":"Pharmacokinetics of doxorubicin after intratumoral injection using a thermosensitive hydrogel in tumor-bearing mice","volume":"142","author":"Al-Abd","year":"2010","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.ejphar.2013.08.009_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1349-7006.2007.00700.x","article-title":"Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel","volume":"99","author":"Al-Abd","year":"2008","journal-title":"Cancer Science"},{"key":"10.1016\/j.ejphar.2013.08.009_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2184.2011.00783.x","article-title":"Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro","volume":"44","author":"Al-Abd","year":"2011","journal-title":"Cell Proliferation"},{"key":"10.1016\/j.ejphar.2013.08.009_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11060-005-9001-4","article-title":"Novel drug delivery system using thermoreversible gelation polymer for malignant glioma","volume":"77","author":"Arai","year":"2006","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib5","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/bit.260110607","article-title":"Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius","volume":"11","author":"Arcamone","year":"1969","journal-title":"Biotechnology and Bioengineering"},{"key":"10.1016\/j.ejphar.2013.08.009_bib6","doi-asserted-by":"crossref","unstructured":"Asensio-Lopez, M.C., Sanchez-Mas, J., Pascual-Figal, D.A., Abenza, S., Perez-Martinez, M.T., Valdes, M., Lax, A., 2012. Involvement of ferritin heavy chain in the preventive effect of metformin against doxorubicin-induced cardiotoxicity. Free Radical Biology and Medicine","DOI":"10.1016\/j.freeradbiomed.2012.09.009"},{"key":"10.1016\/j.ejphar.2013.08.009_bib7","first-page":"526","article-title":"Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys","volume":"58","author":"Behling","year":"2006","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.ejphar.2013.08.009_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijpharm.2004.12.021","article-title":"Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing mice","volume":"293","author":"Bibby","year":"2005","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejphar.2013.08.009_bib9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3835(88)90113-9","article-title":"The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells","volume":"41","author":"Cervantes","year":"1988","journal-title":"Cancer Letters"},{"key":"10.1016\/j.ejphar.2013.08.009_bib10","first-page":"56","article-title":"Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization","volume":"1","author":"Chapman","year":"2011","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Advances in Enzyme Regulation"},{"key":"10.1016\/j.ejphar.2013.08.009_bib12","first-page":"191","article-title":"Impact of natural products in modern drug development","volume":"48","author":"Dev","year":"2010","journal-title":"Indian Journal of Experimental Biology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib13","doi-asserted-by":"crossref","unstructured":"El-Bakly, W.M., Louka, M.L., El-Halawany, A.M., Schaalan, M.F., 2012. 6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation. Cancer Chemotherapy and Pharmacology","DOI":"10.1007\/s00280-012-1975-y"},{"key":"10.1016\/j.ejphar.2013.08.009_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0163-7258(85)90031-2","article-title":"Inhibition of nucleoside diphosphate reductase by hydroxybenzohydroxamic acid derivatives","volume":"29","author":"Elford","year":"1985","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.ejphar.2013.08.009_bib15","first-page":"844","article-title":"New ribonucleotide reductase inhibitors with antineoplastic activity","volume":"39","author":"Elford","year":"1979","journal-title":"Cancer Research"},{"key":"10.1016\/j.ejphar.2013.08.009_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.ejphar.2013.08.009_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/1534735412439749","article-title":"Lack of effect of coenzyme q10 on Doxorubicin cytotoxicity in breast cancer cell cultures","volume":"11","author":"Greenlee","year":"2012","journal-title":"Integrative Cancer Therapies"},{"key":"10.1016\/j.ejphar.2013.08.009_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1124\/jpet.105.083980","article-title":"Inhibition of ribonucleotide reductase reduces neointimal formation following balloon injury","volume":"314","author":"Henry","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.ejphar.2013.08.009_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0027-5107(01)00111-7","article-title":"Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death","volume":"477","author":"Herceg","year":"2001","journal-title":"Mutation Research"},{"issue":"4","key":"10.1016\/j.ejphar.2013.08.009_bib20","first-page":"1","article-title":"Anthracyclines in the treatment of cancer. An overview","volume":"54","author":"Hortobagyi","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2013.08.009_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00280-004-0795-0","article-title":"Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cells","volume":"54","author":"Horvath","year":"2004","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib22","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10.1016\/j.ejphar.2013.08.009_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0006-2952(01)00904-2","article-title":"The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine","volume":"63","author":"Kapuscinski","year":"2002","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0168-3659(99)00133-9","article-title":"Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance","volume":"64","author":"Kataoka","year":"2000","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.ejphar.2013.08.009_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/10739680600778456","article-title":"Robust vascular protective effect of hydroxamic acid derivatives in a sickle mouse model of inflammation","volume":"13","author":"Kaul","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.ejphar.2013.08.009_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib27","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1021\/tx000013q","article-title":"Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction","volume":"13","author":"Licata","year":"2000","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib28","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1016\/j.biomaterials.2010.02.068","article-title":"Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer","volume":"31","author":"Maeng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2013.08.009_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(85)80613-X","article-title":"Product of extracellular-superoxide dismutase catalysis","volume":"184","author":"Marklund","year":"1985","journal-title":"FEBS Letters"},{"key":"10.1016\/j.ejphar.2013.08.009_bib30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1475-2867-13-52","article-title":"Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin- treated animals","volume":"13","author":"Osman","year":"2013","journal-title":"Cancer Cell International"},{"key":"10.1016\/j.ejphar.2013.08.009_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2141.2006.06261.x","article-title":"Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells","volume":"135","author":"Raje","year":"2006","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/1933719111413301","article-title":"Aqueous fenugreek seed extract ameliorates adriamycin-induced cytotoxicity and testicular alterations in albino rats","volume":"19","author":"Sakr","year":"2012","journal-title":"Reproduction Science"},{"key":"10.1016\/j.ejphar.2013.08.009_bib33","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.ejphar.2013.08.009_bib34","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1056\/NEJM195912172612502","article-title":"Metalloenzymes and myocardial infarction. III. Lactic dehydrogenase activity of serum-a determinate diagnostic measure","volume":"261","author":"Snodgrass","year":"1959","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ejphar.2013.08.009_bib35","first-page":"1253","article-title":"Somatostatin enhances the chemosensitivity of GBC-SD cell line to doxorubicin through arresting the cell cycle to S phase rather than through the P53\/Bax-depended apoptosis way in vitro","volume":"56","author":"Songgang","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/10408369709006424","article-title":"The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapy","volume":"34","author":"Szekeres","year":"1997","journal-title":"Critical Reviews in Clinical Laboratory Sciences"},{"key":"10.1016\/j.ejphar.2013.08.009_bib37","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/clinchem\/34.11.2208","article-title":"Use of creatine kinase MB isoenzyme for diagnosing myocardial infarction when total creatine kinase activity is high","volume":"34","author":"Thompson","year":"1988","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.ejphar.2013.08.009_bib38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1600-079X.2004.00202.x","article-title":"Melatonin ameliorates bladder damage induced by cyclophosphamide in rats","volume":"38","author":"Topal","year":"2005","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.ejphar.2013.08.009_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1212\/01.WNL.0000042048.85204.3D","article-title":"Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants","volume":"60","author":"Turchan","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2013.08.009_bib40","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(78)92448-0","article-title":"Doxorubicin for liver cancer","volume":"1","author":"Vilaseca","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2013.08.009_bib41","doi-asserted-by":"crossref","first-page":"710","DOI":"10.7326\/0003-4819-91-5-710","article-title":"Risk factors for doxorubicin-induced congestive heart failure","volume":"91","author":"Von Hoff","year":"1979","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.ejphar.2013.08.009_bib42","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ijc.21096","article-title":"Ribonucleotide reductase inhibitors enhance cidofovir-induced apoptosis in EBV-positive nasopharyngeal carcinoma xenografts","volume":"116","author":"Wakisaka","year":"2005","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.ejphar.2013.08.009_bib43","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0024-3205(00)00990-5","article-title":"Effects by doxorubicin on the myocardium are mediated by oxygen free radicals","volume":"68","author":"Xu","year":"2001","journal-title":"Life Sciences"},{"key":"10.1016\/j.ejphar.2013.08.009_bib44","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1476-5381.2009.00268.x","article-title":"Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection","volume":"158","author":"Zhou","year":"2009","journal-title":"British Journal of Pharmacology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913005992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913005992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T12:01:11Z","timestamp":1596456071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913005992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":44,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0014299913005992"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.08.009","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}