{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:49:50Z","timestamp":1792705790158,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.ejphar.2013.08.052","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T23:04:05Z","timestamp":1382828645000},"page":"2-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva)"],"prefix":"10.1016","volume":"722","author":[{"given":"Nissar A.","family":"Darmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixia","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetha","family":"Chebolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Vaezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tursun","family":"Alkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.08.052_bib1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00171041","article-title":"A comparison of the effects of TMB-8 on pressor responses to alpha 1 and alpha 2 adrenoceptor agonists in pithed rats","volume":"351","author":"Aleixandre","year":"1995","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib2","unstructured":"Alkam, T., Chebolu, S., Darmani, N.A., Cyclophosphamide causes activation of protein kinase (PKA) in the brainstem of vomiting least shrews (Cryptotis parva). 10.1016\/j.ejphar.2013.09.080, in press."},{"key":"10.1016\/j.ejphar.2013.08.052_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ceca.2011.10.001","article-title":"Role of TRPC channels, Stim1 and Orai1 in PGF2a-induced calcium signaling in NRK fibroblasts","volume":"51","author":"Almirza","year":"2012","journal-title":"Calcium Cell"},{"key":"10.1016\/j.ejphar.2013.08.052_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1124\/jpet.106.111690","article-title":"D2-like dopamine receptors depolarize dorsal raphe serotonin neurons through the activation of nonselective cationic conductance","volume":"320","author":"Aman","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2013.08.052_bib5","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1002\/jnr.21784","article-title":"Histamine-induced Ca2+ entry in human astrocytoma U373MG cells: evidence for involvement of store-operated channels","volume":"86","author":"Barajas","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.08.052_bib6","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1016\/0014-2999(93)90673-6","article-title":"Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets","volume":"249","author":"Bountra","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/jn.1988.59.2.358","article-title":"Excitation of area postrema neurons by transmitters, peptides and cyclic nucleotides","volume":"59","author":"Carpenter","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib8","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s007020050118","article-title":"Serotonin 5-HT3 antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis","volume":"105","author":"Darmani","year":"1998","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2013.08.052_bib9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pbb.2011.05.025","article-title":"Synergistic antiemetic interactions between serotonergic 5-HT3- and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva)","volume":"99","author":"Darmani","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2013.08.052_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2012.09.008","article-title":"Cisplatin causes over-expression of tachykinin NK(1) receptors and increases ERK1\/2- and PKA-phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem","volume":"698","author":"Darmani","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejphar.2004.02.018","article-title":"Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis","volume":"488","author":"Darmani","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib12","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1021\/cr900117p","article-title":"Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting","volume":"109","author":"Darmani","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejphar.2013.08.052_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2008.03.077","article-title":"Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists","volume":"1214","author":"Darmani","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2013.08.052_bib14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s007020050222","article-title":"The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew)","volume":"106","author":"Darmani","year":"1999","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2013.08.052_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/annonc\/mdq600","article-title":"Update and new trends in antiemetic therapy: the continuing need for novel therapies","volume":"22","author":"Feyer","year":"2011","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.coviro.2012.05.006","article-title":"Towards a human rotavirus disease model","volume":"2","author":"Hagbom","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib17","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0026-895X(25)09557-4","article-title":"Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels","volume":"50","author":"Hargreaves","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jnr.20894","article-title":"Serotonin induces the increase in intracellular Ca2+ that enhances neurite outgrowth in PC12 cells via activation of 5-HT3 receptors and voltage gated channels","volume":"84","author":"Homma","year":"2006","journal-title":"J. Neurosci. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2013.08.052_bib19","doi-asserted-by":"crossref","first-page":"e00265","DOI":"10.1128\/mBio.00265-10","article-title":"Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity","volume":"1","author":"Hyser","year":"2010","journal-title":"Mbio"},{"key":"10.1016\/j.ejphar.2013.08.052_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejpn.2004.11.002","article-title":"Efficacy of flunarizine in the prophylaxis of cyclical vomiting syndrome and abdominal migraine","volume":"9","author":"Kothare","year":"2005","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11373-005-6796-0","article-title":"Involvement of Ca2+ signaling in tachykinin-mediated contractile responses in swine trachea","volume":"12","author":"Lin","year":"2005","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2013.08.052_bib22","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0016-5085(99)70286-6","article-title":"L-type calcium channels in enterchromaffin cells from guinea pig and human duodenal crypts: an in situ study","volume":"117","author":"Lomax","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2013.08.052_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0163-7258(03)00057-3","article-title":"Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity","volume":"99","author":"Minami","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2013.08.052_bib24","first-page":"115","article-title":"Effects of fluvoxamine, a selective serotonin re-uptake inhibitor, on serotonin release from the mouse isolated ileum","volume":"113\u2013114","author":"Minami","year":"2003","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib25","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuint.2010.09.012","article-title":"Activation of the neurokinin-1 receptor in the rat spinal astrocytes induced Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3","volume":"57","author":"Miyano","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2013.08.052_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jchemneu.2010.03.004","article-title":"The human area postrema and other nuclei related to the emetic reflex express cAMP phosphor diesterases4B and 4D","volume":"40","author":"Mori","year":"2010","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.ejphar.2013.08.052_bib27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000088642","article-title":"Protein kinase A and cav1 (L-type) channels are common targets to facilitatory adenosine and muscarinic m1 receptors on rat motoneurons","volume":"14","author":"Oliveira","year":"2005","journal-title":"Neurosignals"},{"key":"10.1016\/j.ejphar.2013.08.052_bib28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0197-0186(02)00047-5","article-title":"Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism","volume":"41","author":"Ono","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2013.08.052_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3390\/toxins2040683","article-title":"Bacterial toxins and the nervous system: neurotoxins and multipotential toxins interacting with neuronal cells","volume":"2","author":"Poppoff","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.ejphar.2013.08.052_bib30","first-page":"1682","article-title":"Phase 1 study of the novel cyclic AMP (cAMP) analogue 8-chloro-cAMP in patients with cancer: toxicity, hormonal, and immunological effects","volume":"5","author":"Propper","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2013.08.052_bib31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0166-4328(96)00075-7","article-title":"Regulation of 5-HT release from enterochromaffin cells","volume":"73","author":"Racke","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2013.08.052_bib32","doi-asserted-by":"crossref","first-page":"C324","DOI":"10.1152\/ajpcell.00397.2009","article-title":"PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers","volume":"299","author":"Rodr\u00edguez-Lagunas","year":"2010","journal-title":"Am. J. Cell Physiol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2012.01.046","article-title":"Pharmacological mechanisms of 5-HT3 and tachykinin NK1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting","volume":"684","author":"Rojas","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0143-4160(97)90020-8","article-title":"5-HT3 receptors induce rises in cytosolic and nuclear calcium in NG108-15 via calcium-induced calcium release","volume":"22","author":"Ronde","year":"1997","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2013.08.052_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0741-8329(99)00005-1","article-title":"Opposite effects of ethanol and nitrendipine on nicotine-induced emesis and convulsions","volume":"18","author":"Samardzic","year":"1999","journal-title":"Alcohol"},{"key":"10.1016\/j.ejphar.2013.08.052_bib36","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1023\/A:1012332500946","article-title":"Proteinkinase C is involved in M1-muscarinic receptor-mediated facilitation of l-type Ca2+ channels in neurons of the major pelvic ganglion of the adult male rat","volume":"26","author":"Sculptoreano","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2013.08.052_bib37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.semcdb.2011.07.014","article-title":"Sensing change: the emerging role of calcium sensors in neuronal disease","volume":"22","author":"Seaton","year":"2011","journal-title":"Stem Cells Dev. Biol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.bjp.0701012","article-title":"The effects of recombinant rat u-opioid receptor activation in CHO cells on phospholipase C, [Ca2+]I and adenylyl cyclase","volume":"120","author":"Smart","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib40","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.bjp.0707335","article-title":"IP3 receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in Hela-S3 cells and prevents activation of calpain and induction of apoptosis","volume":"151","author":"Splettstoesser","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejphar.2012.05.037","article-title":"Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects","volume":"689","author":"Stathis","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ceca.2011.11.003","article-title":"Molecular mechanisms of pituitary endocrine cell calcium handling","volume":"51","author":"Stojilkovic","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2013.08.052_bib43","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molimm.2009.10.013","article-title":"L-type Ca2+ channels: a new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells","volume":"47","author":"Suzuki","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3940(98)00253-5","article-title":"Serotonin increases Ca2+ concentration in PC12h cells: effect of tachikinin peptides","volume":"24","author":"Takenouchi","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2013.08.052_bib45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-201x.1999.00537.x","article-title":"The effects on net fluid transport of noxious stimulation of jejunal mucosa in anesthetized rats","volume":"166","author":"Timar Peregrin","year":"1999","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2013.08.052_bib46","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00502618","article-title":"Differential effect of calcium entry blockers on alpha 1-adrenoceptor-mediated vasoconstriction in vivo","volume":"324","author":"Timmermans","year":"1983","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2007.01.016","article-title":"Calcium channel antagonists: clinical uses-past, present and future","volume":"74","author":"Triggle","year":"2007","journal-title":"Biochemcal. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib48","first-page":"123","article-title":"Cyclic vomiting syndrome: case report and short review of the literature","volume":"67","author":"Van Driessche","year":"2012","journal-title":"Acta Clin. Belg."},{"key":"10.1016\/j.ejphar.2013.08.052_bib49","first-page":"481","article-title":"Dopamine receptor regulation of Ca2+ levels in individual isolated nerve terminals from rat striatum: comparison of presynaptic D1-like and D2-like receptors","volume":"98","author":"Wu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.08.052_bib50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/CCO.0b013e328352f6fb","article-title":"Management of highly emetogenic chemotherapy","volume":"24","author":"Warr","year":"2012","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib51","first-page":"1105","article-title":"Dopamine and ethanol cause translocation od ePKC associated with eRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase c signaling pathways","volume":"73","author":"Yao","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2013.08.052_bib52","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/sj.bjp.0702008","article-title":"Histamine H1-receptor-mediated increase in the Ca2+ transient without a change in the Ca2+ current in electrically stimulated guinea-pig atrial myocytes","volume":"124","author":"Yoshimoto","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib53","first-page":"734","article-title":"Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydrpyridine Ca2+ channel activator, in cardiac and vascular preparations","volume":"40","author":"Zheng","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.08.052_bib54","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tips.2011.02.012","article-title":"Structural and functional differences between l-type calcium channels: crucial issues for future selective targeting","volume":"32","author":"Zuccotti","year":"2011","journal-title":"Trends Pharmacol. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991300798X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991300798X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T18:28:04Z","timestamp":1746037684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991300798X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":53,"alternative-id":["S001429991300798X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.08.052","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.08.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}