{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:02:03Z","timestamp":1792098123597,"version":"4.4.0"},"reference-count":124,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.ejphar.2013.11.039","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T16:31:26Z","timestamp":1386779486000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["Defining the role of NMDA receptors in anesthesia: Are we there yet?"],"prefix":"10.1016","volume":"723","author":[{"given":"Andrey B.","family":"Petrenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yamakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.11.039_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00000542-200408000-00023","article-title":"Relative amnesic potency of five inhalational anesthetics follows the Meyer\u2013Overton rule","volume":"101","author":"Alkire","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.1149213","article-title":"Consciousness and anesthesia","volume":"322","author":"Alkire","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2013.11.039_bib3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.anes.0000270741.33766.24","article-title":"Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat","volume":"107","author":"Alkire","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1476-5381.1983.tb11031.x","article-title":"The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate","volume":"79","author":"Anis","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00000542-200002000-00030","article-title":"Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 1): effects on axon terminals of GABAergic and glycinergic neurons","volume":"92","author":"Baba","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib6","doi-asserted-by":"crossref","unstructured":"Blanke, M.L., VanDongen, A.M.J., 2009. Activation Mechanisms of the NMDA Receptor. In: Van Dongen, A.M. (Ed.), Biology of the NMDA Receptor, Boca Raton (FL).","DOI":"10.1201\/9781420044157.ch13"},{"key":"10.1016\/j.ejphar.2013.11.039_bib7","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/00000542-199911000-00029","article-title":"Human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes predict efficacy of halogenated compounds that disobey the Meyer\u2013Overton rule","volume":"91","author":"Cardoso","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature715","article-title":"Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits","volume":"415","author":"Chatterton","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.11.039_bib9","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/ALN.0b013e3182518bfc","article-title":"Active emergence from propofol general anesthesia is induced by methylphenidate","volume":"116","author":"Chemali","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1523\/JNEUROSCI.3481-08.2009","article-title":"HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine","volume":"29","author":"Chen","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib11","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1523\/JNEUROSCI.5024-05.2006","article-title":"Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate","volume":"26","author":"Cheng","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ana.21050","article-title":"Paraneoplastic anti-N-methyl-d-aspartate receptor encephalitis associated with ovarian teratoma","volume":"61","author":"Dalmau","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0091-3057(90)90134-4","article-title":"The noncompetitive N-methyl-d-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics","volume":"36","author":"Daniell","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2013.11.039_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/30748","article-title":"Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A","volume":"393","author":"Das","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.11.039_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/bja\/aeh165","article-title":"Editorial I: powerful tools require careful handling \u2013 the case of the circadian ketamine effect","volume":"92","author":"Durieux","year":"2004","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib16","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1213\/01.ane.0000205759.67123.76","article-title":"Do N-methyl-d-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?","volume":"102","author":"Dutton","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib17","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1097\/00000542-200306000-00011","article-title":"Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia","volume":"98","author":"Dutton","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib18","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00000539-200110000-00029","article-title":"Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake","volume":"93","author":"Eger","year":"2001","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1213\/00000539-199704000-00039","article-title":"Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites","volume":"84","author":"Eger","year":"1997","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib20","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1213\/01.ANE.0000219019.91281.51","article-title":"Contrasting roles of the N-methyl-d-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics","volume":"102","author":"Eger","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1213\/ane.0b013e318182aedb","article-title":"Is a new paradigm needed to explain how inhaled anesthetics produce immobility?","volume":"107","author":"Eger","year":"2008","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib22","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1213\/00000539-200206000-00023","article-title":"Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics","volume":"94","author":"Eger","year":"2002","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/eujp.1999.0154","article-title":"Wind-up and the NMDA receptor complex from a clinical perspective","volume":"4","author":"Eide","year":"2000","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2013.11.039_bib24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0885-3924(00)00213-X","article-title":"Targeting the N-methyl-d-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions","volume":"20","author":"Fisher","year":"2000","journal-title":"J. Pain Symptom Manag."},{"key":"10.1016\/j.ejphar.2013.11.039_bib25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00000542-199704000-00016","article-title":"Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected","volume":"86","author":"Flood","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib26","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00000542-200210000-00023","article-title":"Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex","volume":"97","author":"Flood","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0896-6273(94)90350-6","article-title":"Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death","volume":"13","author":"Forrest","year":"1994","journal-title":"Neuron"},{"issue":"Suppl 1","key":"10.1016\/j.ejphar.2013.11.039_bib28","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1038\/sj.bjp.0706441","article-title":"Molecular targets underlying general anaesthesia","volume":"147","author":"Franks","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/24525","article-title":"How does xenon produce anaesthesia?","volume":"396","author":"Franks","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.11.039_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1744-8069-6-25","article-title":"Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons","volume":"6","author":"Georgiev","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2013.11.039_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pain.2007.03.026","article-title":"Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons","volume":"134","author":"Georgiev","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2013.11.039_bib32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1213\/ane.0b013e318193c634","article-title":"Awareness during anesthesia: risk factors, causes and sequelae: a review of reported cases in the literature","volume":"108","author":"Ghoneim","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/sj.npp.1300317","article-title":"Motor-learning impairment by amantadine in healthy volunteers","volume":"29","author":"Hadj Tahar","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bpa.2005.08.014","article-title":"Special cases: ketamine, nitrous oxide and xenon","volume":"20","author":"Hirota","year":"2006","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/bja\/77.4.441","article-title":"Ketamine: its mechanism(s) of action and unusual clinical uses","volume":"77","author":"Hirota","year":"1996","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib36","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/00000539-200105000-00020","article-title":"Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics","volume":"92","author":"Hollmann","year":"2001","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib37","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/ALN.0b013e318225cee5","article-title":"Intranasal application of xenon reduces opioid requirement and postoperative pain in patients undergoing major abdominal surgery: a randomized controlled trial","volume":"115","author":"Holstrater","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0091-3057(91)90206-H","article-title":"d-1 agonist, SKF 38393, but not a D-2 agonist, produces a cholinergically mediated analeptic effect in rabbits","volume":"39","author":"Horita","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2013.11.039_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0022-3565(25)38447-8","article-title":"The analeptic effect of methamphetamine in pentobarbital-narcotized rats is mediated via a dopaminergic\u2013cholinergic mechanism","volume":"268","author":"Horita","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2013.11.039_bib40","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1523\/JNEUROSCI.0167-10.2010","article-title":"Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis","volume":"30","author":"Hughes","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0169-328X(95)00107-4","article-title":"Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel","volume":"33","author":"Ikeda","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.ejphar.2013.11.039_bib42","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/BF03016634","article-title":"MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility","volume":"54","author":"Irifune","year":"2007","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib43","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1213\/01.ane.0000263267.04198.36","article-title":"Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice","volume":"104","author":"Irifune","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(92)91525-J","article-title":"Ketamine-induced anesthesia involves the N-methyl-d-aspartate receptor-channel complex in mice","volume":"596","author":"Irifune","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2013.11.039_bib45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1744-8069-9-11","article-title":"No evidence for the development of acute analgesic tolerance during and hyperalgesia after prolonged remifentanil administration in mice","volume":"9","author":"Ishii","year":"2013","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2013.11.039_bib46","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/bja\/75.5.636","article-title":"Intrathecal administration of N-methyl-d-aspartate receptor antagonist reduces the minimum alveolar anaesthetic concentration of isoflurane in rats","volume":"75","author":"Ishizaki","year":"1995","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib47","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF03017958","article-title":"Intrathecally administered NMDA receptor antagonists reduce the MAC of isoflurane in rats","volume":"43","author":"Ishizaki","year":"1996","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib48","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nm0498-460","article-title":"Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin","volume":"4","author":"Jevtovic-Todorovic","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2013.11.039_bib49","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1523\/JNEUROSCI.16-24-07859.1996","article-title":"Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit","volume":"16","author":"Kadotani","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib50","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1213\/01.ane.0000261519.04083.3e","article-title":"Increased gamma-aminobutyric acid levels in mouse brain induce loss of righting reflex, but not immobility, in response to noxious stimulation","volume":"104","author":"Katayama","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2044.2011.06707.x","article-title":"Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-d-aspartate receptor antibodies","volume":"66","author":"Kawano","year":"2011","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ejphar.2013.11.039_bib52","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0031-9384(93)90248-E","article-title":"Behavioral and electrophysiological comparison of ketamine with dizocilpine in the rat","volume":"54","author":"Kelland","year":"1993","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2013.11.039_bib53","first-page":"1186","article-title":"Ketamine: teaching an old drug new tricks","volume":"87","author":"Kohrs","year":"1998","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0896-6273(00)80051-3","article-title":"Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice","volume":"16","author":"Kutsuwada","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2013.11.039_bib55","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.ejphar.2013.11.039_bib56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/16469","article-title":"Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord","volume":"397","author":"Li","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.11.039_bib57","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1152\/physrev.00042.2003","article-title":"Molecular structure and function of the glycine receptor chloride channel","volume":"84","author":"Lynch","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2013.11.039_bib58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0006-2952(94)00519-R","article-title":"Volatile anesthetics and glutamate activation of N-methyl-d-aspartate receptors","volume":"49","author":"Martin","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib59","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/ALN.0b013e3181bbc961","article-title":"Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade","volume":"111","author":"Martin","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib60","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2170\/jjphysiol.50.163","article-title":"Abnormal air-righting reflex in striatal rats","volume":"50","author":"Masuda","year":"2000","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib61","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones","volume":"309","author":"Mayer","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.11.039_bib62","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1213\/01.ANE.0000108501.57073.38","article-title":"A qualitative systematic review of the role of N-methyl-d-aspartate receptor antagonists in preventive analgesia","volume":"98","author":"McCartney","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib63","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/00000542-200009000-00020","article-title":"Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers","volume":"93","author":"Meuret","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib64","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/brain\/aws092","article-title":"Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis","volume":"135","author":"Mikasova","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2013.11.039_bib65","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1523\/JNEUROSCI.21-02-00750.2001","article-title":"Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit","volume":"21","author":"Miyamoto","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib66","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1523\/JNEUROSCI.22-06-02335.2002","article-title":"Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit","volume":"22","author":"Miyamoto","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib67","unstructured":"Monaghan, D.T., Jane, D.E., 2009. Pharmacology of NMDA Receptors. In: Van Dongen, A.M. (Ed.), Biology of the NMDA Receptor, Boca Raton (FL)."},{"key":"10.1016\/j.ejphar.2013.11.039_bib68","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s00213-006-0572-3","article-title":"Acute and chronic effects of ketamine upon human memory: a review","volume":"188","author":"Morgan","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2013.11.039_bib69","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.lfs.2003.09.020","article-title":"Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting","volume":"74","author":"Mori","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbr.2008.02.011","article-title":"Postural performance in decerebrated rabbit","volume":"190","author":"Musienko","year":"2008","journal-title":"Behav. Brain. Res."},{"key":"10.1016\/j.ejphar.2013.11.039_bib71","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.1073\/pnas.0402825101","article-title":"Nitrous oxide (N(2)O) requires the N-methyl-d-aspartate receptor for its action in Caenorhabditis elegans","volume":"101","author":"Nagele","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2013.11.039_bib72","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00000542-200509000-00013","article-title":"Xenon acts by inhibition of non-N-methyl-d-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans","volume":"103","author":"Nagele","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib73","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1329206","article-title":"Molecular diversity of glutamate receptors and implications for brain function","volume":"258","author":"Nakanishi","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2013.11.039_bib74","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1460-9568.2007.05774.x","article-title":"Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes","volume":"26","author":"Niemann","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib75","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1124\/jpet.106.101691","article-title":"Effects of anesthetics on mutant N-methyl-d-aspartate receptors expressed in Xenopus oocytes","volume":"318","author":"Ogata","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2013.11.039_bib76","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00000542-200310000-00030","article-title":"Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats","volume":"99","author":"Ohashi","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib77","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0006-8993(98)01110-X","article-title":"Effect of dopamine content in rat brain striatum on anesthetic requirement: an in vivo microdialysis study","volume":"817","author":"Onozawa","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2013.11.039_bib78","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00000542-199704000-00021","article-title":"Multiple mechanisms of ketamine blockade of N-methyl-d-aspartate receptors","volume":"86","author":"Orser","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib79","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0022-3565(25)11430-4","article-title":"Effects of ketamine on sensory perception: evidence for a role of N-methyl-d-aspartate receptors","volume":"260","author":"Oye","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2013.11.039_bib80","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijgo.2011.07.028","article-title":"Anesthetic management of ovarian teratoma excision associated with anti-N-methyl-d-aspartate receptor encephalitis","volume":"115","author":"Pascual-Ramirez","year":"2011","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.ejphar.2013.11.039_bib81","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s005400170050","article-title":"A possible role for glutamate receptor-mediated excitotoxicity in chronic pain","volume":"15","author":"Petrenko","year":"2001","journal-title":"J. Anesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib82","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuropharm.2005.11.019","article-title":"Effects of ketamine on acute somatic nociception in wild-type and N-methyl-d-aspartate (NMDA) receptor epsilon1 subunit knockout mice","volume":"50","author":"Petrenko","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib83","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0168-0102(03)00061-0","article-title":"Unaltered pain-related behavior in mice lacking NMDA receptor GluRepsilon 1 subunit","volume":"46","author":"Petrenko","year":"2003","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.11.039_bib84","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1213\/01.ANE.0000081061.12235.55","article-title":"The role of N-methyl-d-aspartate (NMDA) receptors in pain: a review","volume":"97","author":"Petrenko","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib85","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1213\/01.ANE.0000131729.54986.30","article-title":"Reduced sensitivity to ketamine and pentobarbital in mice lacking the N-methyl-d-aspartate receptor GluRepsilon1 subunit","volume":"99","author":"Petrenko","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib86","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1213\/ANE.0b013e3181c76e73","article-title":"Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking the N-methyl-d-aspartate receptor GluR(epsilon)1 subunit are caused by the secondary effects of gene knockout","volume":"110","author":"Petrenko","year":"2010","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib87","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejphar.2012.10.034","article-title":"Increased brain monoaminergic tone after the NMDA receptor GluN2A subunit gene knockout is responsible for resistance to the hypnotic effect of nitrous oxide","volume":"698","author":"Petrenko","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib88","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/bja\/aeg209","article-title":"Antagonism of sevoflurane anaesthesia by physostigmine: effects on the auditory steady-state response and bispectral index","volume":"91","author":"Plourde","year":"2003","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib89","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1213\/ANE.0b013e31822b8a7d","article-title":"Case report: anti-N-methyl-d-aspartate receptor encephalitis and its anesthetic implications","volume":"113","author":"Pryzbylkowski","year":"2011","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib90","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1213\/00000539-200209000-00016","article-title":"Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics","volume":"95","author":"Quinlan","year":"2002","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib91","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1213\/ANE.0b013e3181bf6ae6","article-title":"Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane","volume":"109","author":"Rau","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib92","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1213\/ANE.0b013e3182273aff","article-title":"Gamma-aminobutyric acid type A receptor beta3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane","volume":"113","author":"Rau","year":"2011","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib93","series-title":"Miller's Anesthesia","first-page":"719","article-title":"Intravenous Anesthetics","author":"Reves","year":"2010"},{"key":"10.1016\/j.ejphar.2013.11.039_bib94","doi-asserted-by":"crossref","unstructured":"Rezvani, A.H., 2006. Involvement of the NMDA System in Learning and Memory, in: Levin, E.D., Buccafusco, J.J. (Eds.), Animal Models of Cognitive Impairment, Boca Raton (FL).","DOI":"10.1201\/9781420004335.ch4"},{"key":"10.1016\/j.ejphar.2013.11.039_bib95","first-page":"1349","article-title":"[Low doses ketamine: antihyperalgesic drug, non-analgesic]","volume":"24","author":"Richebe","year":"2005","journal-title":"Ann. Fr. Anesth. Reanim."},{"key":"10.1016\/j.ejphar.2013.11.039_bib96","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.npp.1300642","article-title":"Selective cognitive impairments associated with NMDA receptor blockade in humans","volume":"30","author":"Rowland","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib97","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/373151a0","article-title":"Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit","volume":"373","author":"Sakimura","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.11.039_bib98","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/bja\/aeh144","article-title":"Chronopharmacological studies of ketamine in normal and NMDA epsilon1 receptor knockout mice","volume":"92","author":"Sato","year":"2004","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib99","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00000542-200503000-00013","article-title":"Effect of N-methyl-d-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice","volume":"102","author":"Sato","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib100","doi-asserted-by":"crossref","first-page":"9242","DOI":"10.1523\/JNEUROSCI.20-24-09242.2000","article-title":"Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors","volume":"20","author":"Sawamura","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib101","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0028-3908(89)90150-0","article-title":"The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits","volume":"28","author":"Scheller","year":"1989","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib102","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/ALN.0b013e31822e92e5","article-title":"Methylphenidate actively induces emergence from general anesthesia","volume":"115","author":"Solt","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib103","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1213\/01.ane.0000204252.07406.9f","article-title":"Differential modulation of human N-methyl-d-aspartate receptors by structurally diverse general anesthetics","volume":"102","author":"Solt","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib104","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1213\/01.ANE.0000081063.76651.33","article-title":"Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration","volume":"97","author":"Sonner","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib105","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1213\/00000539-200301000-00022","article-title":"Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane","volume":"96","author":"Stabernack","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib106","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1177\/0310057X1003800513","article-title":"Intraoperative nitrous oxide as a preventive analgesic","volume":"38","author":"Stiglitz","year":"2010","journal-title":"Anaesth. Intensive Care"},{"key":"10.1016\/j.ejphar.2013.11.039_bib107","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1213\/01.ane.0000244334.52163.a3","article-title":"Do dopamine receptors mediate part of MAC?","volume":"103","author":"Tanifuji","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib108","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ALN.0b013e318278c896","article-title":"Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia","volume":"118","author":"Taylor","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib109","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/00000542-199704000-00017","article-title":"Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics","volume":"86","author":"Violet","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12630-010-9428-8","article-title":"Inhibition of learning and memory by general anesthetics","volume":"58","author":"Wang","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.ejphar.2013.11.039_bib111","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1097\/00001756-199212000-00027","article-title":"Developmental changes in distribution of NMDA receptor channel subunit mRNAs","volume":"3","author":"Watanabe","year":"1992","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2013.11.039_bib112","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/cne.903450212","article-title":"Distinct spatiotemporal distributions of the N-methyl-d-aspartate receptor channel subunit mRNAs in the mouse cervical cord","volume":"345","author":"Watanabe","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib113","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1213\/01.ANE.0000152324.30272.49","article-title":"The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-d-aspartate receptors","volume":"100","author":"Yamakura","year":"2005","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib114","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1097\/00000542-200004000-00033","article-title":"Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine","volume":"92","author":"Yamakura","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib115","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00000542-200010000-00034","article-title":"Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol","volume":"93","author":"Yamakura","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2013.11.039_bib116","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00001756-199306000-00021","article-title":"Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists","volume":"4","author":"Yamakura","year":"1993","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2013.11.039_bib117","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0301-0082(99)00007-6","article-title":"Subunit- and site-specific pharmacology of the NMDA receptor channel","volume":"59","author":"Yamakura","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib118","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1749-6632.1991.tb33851.x","article-title":"Effects of isoflurane on N-methyl-d-aspartate gated ion channels in cultured rat hippocampal neurons","volume":"625","author":"Yang","year":"1991","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejphar.2013.11.039_bib119","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1990.sp018293","article-title":"Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord","volume":"430","author":"Yoshimura","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2013.11.039_bib120","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1213\/01.ANE.0000070229.94485.17","article-title":"Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics","volume":"97","author":"Zhang","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib121","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1213\/00000539-200301000-00021","article-title":"Glycine receptors mediate part of the immobility produced by inhaled anesthetics","volume":"96","author":"Zhang","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib122","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1213\/01.ANE.0000118108.64886.42","article-title":"Gamma-aminobutyric acid A receptors do not mediate the immobility produced by isoflurane","volume":"99","author":"Zhang","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib123","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00000539-200101000-00024","article-title":"Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane","volume":"92","author":"Zhang","year":"2001","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2013.11.039_bib124","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/ALN.0b013e318287b7c8","article-title":"Forebrain HCN1 channels contribute to hypnotic actions of ketamine","volume":"118","author":"Zhou","year":"2013","journal-title":"Anesthesiology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991300914X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991300914X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T04:17:52Z","timestamp":1746073072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991300914X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":124,"alternative-id":["S001429991300914X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.11.039","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defining the role of NMDA receptors in anesthesia: Are we there yet?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}