{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:45:10Z","timestamp":1770511510203,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.ejphar.2013.12.031","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T23:01:11Z","timestamp":1388703671000},"page":"102-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator"],"prefix":"10.1016","volume":"724","author":[{"given":"Philip E.","family":"Brandish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen A.","family":"Baltus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Bungard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Bunting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Byford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Sung","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milenko","family":"Cicmil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halea","family":"Corcoran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Euler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gambone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Hasbun-Manning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Kuklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Landis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Traci Q.","family":"Lifsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"McElwee-Witmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian S.","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Musselman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azriel","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Szczerba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Tribouley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Hershey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.12.031_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jsbmb.2010.03.058","article-title":"The role of the glucocorticoid receptor in inflammation and immunity","volume":"120","author":"Baschant","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1210\/er.2009-0013","article-title":"Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases","volume":"30","author":"Beck","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2013.12.031_bib3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1517\/13543776.2010.493876","article-title":"Recent advances in the development of novel glucocorticoid receptor modulators","volume":"20","author":"Berlin","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"issue":"Suppl. 4","key":"10.1016\/j.ejphar.2013.12.031_bib4","first-page":"iv9","article-title":"Disease control with glucocorticoid therapy in rheumatoid arthritis","volume":"51","author":"Bijlsma","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ejphar.2013.12.031_bib5","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1016\/j.bmc.2011.10.054","article-title":"Discovery of selective glucocorticoid receptor modulator MK-5932","volume":"19","author":"Bungard","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2013.12.031_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mce.2007.04.013","article-title":"Anti-inflammatory functions of glucocorticoid-induced genes","volume":"275","author":"Clark","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2011.12.004","article-title":"Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor","volume":"134","author":"Clark","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2013.12.031_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.coph.2010.04.007","article-title":"Targeting inflammation using selective glucocorticoid receptor modulators","volume":"10","author":"De Bosscher","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2748","article-title":"Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells","volume":"10","author":"Glass","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib10","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1136\/ard.2007.072157","article-title":"EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases","volume":"66","author":"Hoes","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2013.12.031_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrrheum.2010.179","article-title":"Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis","volume":"6","author":"Hoes","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib12","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1210\/en.2010-1447","article-title":"The antagonists but not partial agonists of glucocorticoid receptor ligands show substantial side effect dissociation","volume":"152","author":"Hu","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2013.12.031_bib13","first-page":"844","article-title":"The influence of adrenocorticotropic hormone and prednisolone upon marrow and circulating leukocytes in the dog","volume":"26","author":"Jasper","year":"1965","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ejphar.2013.12.031_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1530\/EJE-11-0751","article-title":"Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals","volume":"166","author":"Kauh","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib15","series-title":"Principles of Bone Biology","first-page":"2095","article-title":"Animal models in osteoporosis research","author":"Kimmel","year":"1995"},{"key":"10.1016\/j.ejphar.2013.12.031_bib16","doi-asserted-by":"crossref","first-page":"254S","DOI":"10.3945\/ajcn.2009.28449B","article-title":"Fibroblast growth factor 21: from pharmacology to physiology","volume":"91","author":"Kliewer","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ejphar.2013.12.031_bib17","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1210\/en.2011-1891","article-title":"Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance","volume":"153","author":"Laskewitz","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2013.12.031_bib18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.1164265","article-title":"DNA binding site sequence directs glucocorticoid receptor structure and activity","volume":"324","author":"Meijsing","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2013.12.031_bib19","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1016\/0006-2952(88)90704-6","article-title":"Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity","volume":"37","author":"Meurer","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.12.031_bib20","first-page":"447","article-title":"Circadian rhythmicity of delayed hypersensitivity to oxazolone in the rat","volume":"54","author":"Pownall","year":"1978","journal-title":"Clin. Sci. Mol. Med."},{"key":"10.1016\/j.ejphar.2013.12.031_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)81183-6","article-title":"DNA binding of the glucocorticoid receptor is not essential for survival","volume":"93","author":"Reichardt","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2013.12.031_bib22","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids\u2014new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2013.12.031_bib23","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1210\/er.2005-0002","article-title":"The search for safer glucocorticoid receptor ligands","volume":"26","author":"Rosen","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2013.12.031_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0163-7258(02)00297-8","article-title":"Mechanisms involved in the side effects of glucocorticoids","volume":"96","author":"Schacke","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2013.12.031_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2011.03.027","article-title":"Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor","volume":"145","author":"Surjit","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2013.12.031_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2174\/156802608783955737","article-title":"Recent progress in the discovery of novel glucocorticoid receptor modulators","volume":"8","author":"Takahashi","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejphar.2013.12.031_bib27","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1074\/jbc.C000526200","article-title":"Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-Kappa B and induction of apoptosis","volume":"276","author":"Tao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.12.031_bib28","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1172\/JCI28034","article-title":"Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy","volume":"117","author":"Tuckermann","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2013.12.031_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2362.2008.02067.x","article-title":"Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?","volume":"39","author":"van Raalte","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2013.12.031_bib30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1101\/gad.1400506","article-title":"Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity","volume":"20","author":"Wang","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2013.12.031_bib31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1523-1747.2000.00999.x","article-title":"Chemical activation of innate and specific immunity in contact dermatitis","volume":"115","author":"Zhang","year":"2000","journal-title":"J. Investig. Dermatol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991300959X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991300959X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:04:19Z","timestamp":1726848259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991300959X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":31,"alternative-id":["S001429991300959X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.12.031","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}