{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:49:39Z","timestamp":1791492579489,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002509","name":"Keimyung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.ejphar.2013.12.041","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T03:30:29Z","timestamp":1390966229000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity"],"prefix":"10.1016","volume":"728","author":[{"given":"Dong-Sung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil-Saeng","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.12.041_bib1","doi-asserted-by":"crossref","first-page":"26071","DOI":"10.1074\/jbc.274.37.26071","article-title":"Nrf2, a Cap\u05f3n\u05f3Collar transcription factor, regulates induction of the heme oxygenase-1 gene","volume":"274","author":"Alam","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.12.041_bib2","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1248\/cpb.56.1722","article-title":"Flavonoids from the heartwood of Dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in HT22 cells","volume":"56","author":"An","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2013.12.041_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","article-title":"Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus","volume":"27","author":"Blasi","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2013.12.041_bib5","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/jnr.490310405","article-title":"An immortalized cell line expresses properties of activated microglial cells","volume":"31","author":"Bocchini","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.12.041_bib6","first-page":"2736","article-title":"Activated microglia mediate neuronal cell injury via a nitric oxide mechanism","volume":"149","author":"Chao","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.12.041_bib7","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.4049\/jimmunol.166.6.3873","article-title":"Biphasic regulation of NF-\u03baB activity underlies the pro- and anti-inflammatory actions of nitric oxide","volume":"166","author":"Connelly","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1523\/JNEUROSCI.3732-10.2011","article-title":"HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration","volume":"31","author":"Gao","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.12.041_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.neuro.22.1.219","article-title":"Microglia as mediators of inflammatory and degenerative diseases","volume":"22","author":"Gonzalez-Scarano","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2013.12.041_bib10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.2353\/ajpath.2007.060782","article-title":"Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages","volume":"170","author":"Gueler","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.expneurol.2005.01.013","article-title":"Oxidative stress and inflammation in Parkinson\u05f3s disease: is there a causal link?","volume":"193","author":"Hald","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0891-5849(00)00306-3","article-title":"Regulation of genes encoding NAD(P)H:quinine oxidoreductases","volume":"29","author":"Jaiswal","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2013.12.041_bib13","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.2174\/1389450111009011517","article-title":"Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases","volume":"11","author":"Jazwa","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2013.12.041_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ejphar.2010.12.027","article-title":"Neuroprotective and anti-inflammatory effects of mollugin via up-regulation of heme oxygenase-1 in mouse hippocampal and microglial cells","volume":"654","author":"Jeong","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib15","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.intimp.2010.09.013","article-title":"Cytoprotective and anti-inflammatory effects of spinasterol via the induction of heme oxygenase-1 in murine hippocampal and microglial cell lines","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000332936","article-title":"Microglial activation in neuroinflammation: implications for the etiology of neurodegeneration","volume":"10","author":"Kaneko","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.ejphar.2013.12.041_bib17","first-page":"32","article-title":"Isoliquiritgenin: a competitive tyrosinase inhibitor from the heartwood of Dalbergia odorifera","volume":"13","author":"Kang","year":"2005","journal-title":"J. App. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib18","doi-asserted-by":"crossref","first-page":"e67945","DOI":"10.1371\/journal.pone.0067945","article-title":"Structure\u2013function relationship of substituted bromomethylcoumarins in nucleoside specificity of RNA alkylation","volume":"8","author":"Kellner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2013.12.041_bib19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrd1657","article-title":"The evolving role of natural products in drug discovery","volume":"4","author":"Koehn","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2013.12.041_bib20","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2013.12.041_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2011.11.016","article-title":"Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells","volume":"674","author":"Li","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib22","first-page":"11658","article-title":"Antioxidant activities of seed extracts from Dalbergia odorifera T. Chen","volume":"10","author":"Lianhe","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib23","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jnr.20692","article-title":"Antioxidant and anti-inflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia","volume":"82","author":"Lim","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.12.041_bib24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/374647a0","article-title":"Activation of microglial cells by \u03b2-amyloid protein and interferon-\u03b3","volume":"374","author":"Meda","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2013.12.041_bib25","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/glia.20676","article-title":"Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2","volume":"56","author":"Min","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2013.12.041_bib26","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1046\/j.1471-4159.1995.65062690.x","article-title":"Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures","volume":"65","author":"Minghetti","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2013.12.041_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0168-0102(99)00071-1","article-title":"Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide","volume":"35","author":"Nakamura","year":"1999","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.12.041_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1039\/a902202c","article-title":"The infl uence of natural products upon drug discovery","volume":"17","author":"Newman","year":"2000","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejphar.2013.12.041_bib29","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/np030096l","article-title":"Natural products as sources of new drugs over the period 1981\u20132002","volume":"66","author":"Newman","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejphar.2013.12.041_bib30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-\u03baB: a crucial transcription factor for glial and neuronal cell function","volume":"20","author":"O\u2019Neill","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2013.12.041_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuro.2005.05.008","article-title":"Role of MAPK in ceramide-induced cell death in primary cultured astrocytes from mouse embryonic brain","volume":"27","author":"Oh","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ejphar.2013.12.041_bib32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2013.12.041_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1126\/science.1116364","article-title":"The renaissance of natural products as drug candidates","volume":"310","author":"Paterson","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2013.12.041_bib34","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1100\/tsw.2001.77","article-title":"Anti-inflammatory activity of compounds isolated from plants","volume":"1","author":"Perez","year":"2001","journal-title":"Sci. World J."},{"key":"10.1016\/j.ejphar.2013.12.041_bib35","series-title":"General Chemistry","first-page":"91","author":"Petrucci","year":"2002"},{"key":"10.1016\/j.ejphar.2013.12.041_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF02740619","article-title":"The effects of interferon-\u03b3 on the central nervous system","volume":"14","author":"Popko","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2013.12.041_bib38","first-page":"326","article-title":"Roles of IL-1 and TNF-\u03b1 in endotoxin-induced activation of nitric oxide synthase in cultured rat brain cells","volume":"270","author":"Romero","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1289\/ehp.93100259","article-title":"Toxicology, structure\u2013function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems","volume":"100","author":"Safe","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ejphar.2013.12.041_bib40","first-page":"47","article-title":"PCBs: structure\u2013function relationships and mechanism of action","volume":"60","author":"Safe","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ejphar.2013.12.041_bib41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","article-title":"Structure, regulation and function of NF-\u03baB","volume":"10","author":"Siebenlist","year":"1994","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1165\/rcmb.2005-0154OC","article-title":"CCAAT\/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2","volume":"35","author":"Suh","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00019052-200108000-00009","article-title":"The role of glial cells in Parkinson\u05f3s disease","volume":"14","author":"Vila","year":"2001","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.ejphar.2013.12.041_bib44","doi-asserted-by":"crossref","first-page":"24840","DOI":"10.1074\/jbc.M000835200","article-title":"Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators","volume":"275","author":"Wiesel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.12.041_bib45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1177\/15353702-0322805-26","article-title":"Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children","volume":"228","author":"Yachie","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2013.12.041_bib46","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/15353702-0322805-02","article-title":"Effect of heme oxygenase-1 overexpression in two models of lung inflammation","volume":"228","author":"Zampetaki","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2013.12.041_bib47","doi-asserted-by":"crossref","first-page":"9775","DOI":"10.3390\/molecules16129775","article-title":"Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum","volume":"16","author":"Zhao","year":"2011","journal-title":"Molecules"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914000521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914000521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:03:09Z","timestamp":1762142589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914000521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":47,"alternative-id":["S0014299914000521"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.12.041","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.12.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}