{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:32:19Z","timestamp":1768530739237,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.ejphar.2014.01.023","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:01:01Z","timestamp":1390435261000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Treatment with carnosine reduces hypoxia-ischemia brain damage in a neonatal rat model"],"prefix":"10.1016","volume":"727","author":[{"given":"Huizhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2014.01.023_bib1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/jms.696","article-title":"Pro\ufb01ling histidine-containing dipeptides in rat tissues by liquid chromatography\/electrospray ionization tandemmass spectrometry","volume":"39","author":"Aldini","year":"2004","journal-title":"J. Mass Spectrom."},{"issue":"15","key":"10.1016\/j.ejphar.2014.01.023_bib2","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2741\/3655","article-title":"Telomere attrition in lens epithelial cells\u2014a target for N-acetylcarnosine therapy","volume":"1","author":"Babizhayev","year":"2010","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejphar.2014.01.023_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0006-291X(03)00628-4","article-title":"Mitochondria and ischemic reperfusion damage in the adult and in the developing brain","volume":"304","author":"Blomgren","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2014.01.023_bib4","doi-asserted-by":"crossref","first-page":"10191","DOI":"10.1074\/jbc.M007807200","article-title":"Synergistic activation of caspase-3 by m-calpain after neonatal poxia-ischemia: a mechanism of \u2018\u2018pathological apoptosis\u2019\u2019","volume":"276","author":"Blomgren","year":"2001","journal-title":"J. Bhyiol. Chem."},{"key":"10.1016\/j.ejphar.2014.01.023_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0306-4522(99)00273-0","article-title":"Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species","volume":"94","author":"Boldyrev","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2014.01.023_bib6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.STR.0000055763.76479.E6","article-title":"Selective neuromicrovascular endothelial cell death by 8-iso-prostaglandinF2\u03b1: possible role in ischemic brain injury","volume":"34","author":"Brault","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2014.01.023_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1203\/01.PDR.0000099774.17723.D4","article-title":"Increased brain levels of F2-isoprostane are an early marker of behavioral sequels in a rat model of global perinatal asphyxia","volume":"55","author":"Calamandrei","year":"2004","journal-title":"J. Pediatr. Res."},{"key":"10.1016\/j.ejphar.2014.01.023_bib8","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.STR.27.6.1124","article-title":"Role of oxidants in ischemia brain damage","volume":"27","author":"Chan","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2014.01.023_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000295663","article-title":"Treatment of Alzheimer\u05f3s disease with a cholinesterase inhibitor combined with antioxidants","volume":"7","author":"Cornelli","year":"2010","journal-title":"Neurodegener Dis."},{"key":"10.1016\/j.ejphar.2014.01.023_bib10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0248-8663(00)80056-9","article-title":"Isoprostanes: new markers of oxidative stress. Fundamental and clinical aspects","volume":"21","author":"Cracowski","year":"2000","journal-title":"Rev. Med. Interne."},{"key":"10.1016\/j.ejphar.2014.01.023_bib11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.spen.2009.09.001","article-title":"Evolving understanding of hypoxic-ischemic encephalopathy in the term infant","volume":"16","author":"De Vries","year":"2009","journal-title":"Semin. Pediatr. Neurol."},{"issue":"82","key":"10.1016\/j.ejphar.2014.01.023_bib12","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bcp.2011.07.074","article-title":"Administra-tion of carnosine in the treatment of acute spinal cord injury","volume":"15","author":"Di Paola","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.01.023_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pharmthera.2008.07.003","article-title":"Therapeutics for neonatal brain injury","volume":"120","author":"Gonzalez","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2014.01.023_bib14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.clp.2009.07.013","article-title":"Neuroprotection in the newborn infant","volume":"36","author":"Gonzalez","year":"2009","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.ejphar.2014.01.023_bib15","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1161\/hs1101.098653","article-title":"Oxygen radicals in cerebral ischemia: the 2001 Willis lecture","volume":"32","author":"Hermes","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2014.01.023_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0952-3278(98)90124-7","article-title":"Role of 8-iso-PGF2alpha, 8-isoprostane, in H2O2-induced derangements of pulmonary artery endothelial cell barrier function","volume":"58","author":"Hart","year":"1998","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.ejphar.2014.01.023_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1528-1157.1999.tb01982.x","article-title":"The neuropathology of hyperthermic seizures in the rat","volume":"40","author":"Jiang","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2014.01.023_bib18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4162\/nrp.2011.5.5.421","article-title":"Effects of \u03b1-lipoic acid and l-carnosine supplementation on antioxidant activities and lipid profiles in rats","volume":"5","author":"Kim","year":"2011","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.ejphar.2014.01.023_bib19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1134\/S1819712408030112","article-title":"Carnosine protects from oxidative stress induced by hyperhomocysteinemia","volume":"3","author":"Makhro","year":"2008","journal-title":"Neurochem. J."},{"key":"10.1016\/j.ejphar.2014.01.023_bib20","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0005-2760(94)90128-7","article-title":"Evidence that the F2-isoprostane, 8-iso-prostaglandin F2alpha, is formed in vivo","volume":"1210","author":"Morrow","year":"1994","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.ejphar.2014.01.023_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12291-010-0018-x","article-title":"Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats","volume":"25","author":"Noori","year":"2010","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.ejphar.2014.01.023_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neulet.2006.10.024","article-title":"Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: an in vivo microdialysis study","volume":"414","author":"Noor","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2014.01.023_bib23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3164\/jcbn.09-125","article-title":"Polaprezinc protects mice against endotoxin shock","volume":"46","author":"Ohata","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.ejphar.2014.01.023_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11010-009-0369-x","article-title":"Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress","volume":"339","author":"Ozel Turkcu","year":"2010","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.ejphar.2014.01.023_bib25","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1476-5381.1996.tb15535.x","article-title":"Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation","volume":"118","author":"Patrignani","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.01.023_bib26","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1128\/AEM.01369-10","article-title":"Antiglycation effects of carnosine and other compounds on the long-term survival of Escherichia coli","volume":"76","author":"Pepper","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejphar.2014.01.023_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bcp.2006.11.007","article-title":"Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine\u2013histidine\u2013histamine pathway and H1\/H3 receptors","volume":"73","author":"Shen","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.01.023_bib28","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2014.01.023_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.JPN.0000346221.48202.7e","article-title":"The chilling details: hypoxic-ischemic encephalopathy","volume":"23","author":"Verklan","year":"2009","journal-title":"J. Perinat. Neonatal Nurs."},{"key":"10.1016\/j.ejphar.2014.01.023_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000085978","article-title":"Perinatal hypoxic-ischemic brain damage: evolution of an animal model","volume":"27","author":"Vannucci","year":"2005","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.ejphar.2014.01.023_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejphar.2011.06.003","article-title":"Carnosine pretreatment protects against hypoxia-ischemia brain damage in the neonatal rat model","volume":"667","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:55:51Z","timestamp":1538873751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":31,"alternative-id":["S0014299914000247"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.023","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with carnosine reduces hypoxia-ischemia brain damage in a neonatal rat model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}