{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:57:38Z","timestamp":1772751458417,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.ejphar.2014.01.063","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T17:30:38Z","timestamp":1392139838000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Cardioprotective effects of magnesium valproate in type 2 diabetes mellitus"],"prefix":"10.1016","volume":"728","author":[{"given":"Bhoomika M.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchi","family":"Raghunathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urvashi","family":"Porwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2014.01.063_bib1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.ajpath.2011.01.044","article-title":"Long-term administration of the histone deacetylase inhibitor ovrinostat attenuates Renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism","volume":"178","author":"Advani","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2014.01.063_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1758-5996-1-17","article-title":"Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats","volume":"1","author":"Amin","year":"2009","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.ejphar.2014.01.063_bib3","doi-asserted-by":"crossref","first-page":"28930","DOI":"10.1074\/jbc.M303113200","article-title":"Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors","volume":"278","author":"Antos","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2014.01.063_bib4","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2014.01.063_bib5","first-page":"363","article-title":"Effect of supervised integrated exercise on heart rate variability in type 2 diabetes mellitus","volume":"65","author":"Bhagyalakshmi","year":"2007","journal-title":"Kardiol. Pol."},{"key":"10.1016\/j.ejphar.2014.01.063_bib6","first-page":"126","article-title":"Magnesium valproate","volume":"12","author":"Bhatia","year":"2009","journal-title":"Delhi Psychiatry J."},{"key":"10.1016\/j.ejphar.2014.01.063_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.110.154567","article-title":"HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats","volume":"56","author":"Cardinale","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2014.01.063_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1186\/1471-2164-9-507","article-title":"Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism","volume":"9","author":"Chittur","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ejphar.2014.01.063_bib9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2119\/molmed.2011.00021","article-title":"Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus","volume":"17","author":"Christensen","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2014.01.063_bib10","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.freeradbiomed.2007.03.007","article-title":"Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury","volume":"42","author":"Daosukho","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ejphar.2014.01.063_bib11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.pharmthera.2005.10.008","article-title":"Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets","volume":"111","author":"Farhangkhoee","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2014.01.063_bib12","first-page":"1449","article-title":"Oxidative stress and diabetic complications","volume":"106","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2014.01.063_bib13","doi-asserted-by":"crossref","first-page":"A30","DOI":"10.1136\/ard.2010.149104.15","article-title":"Histone deacetylase inhibitors suppress IL-6 production by rheumatoid arthritis firoblast-like synoviocytes and macrophages via modulation of mRNA stability rather than blockade of NF-\u03baB signalling","volume":"70","author":"Grabiec","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2014.01.063_bib14","first-page":"353","article-title":"Effects of chronic ramipril treatment in streptozotocin-induced diabetic rats","volume":"41","author":"Hakim","year":"1997","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.01.063_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/CS20040057","article-title":"Diabetic cardiomyopathy: mechanism, diagnosis and treatment","volume":"107","author":"Hayat","year":"2004","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ejphar.2014.01.063_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0006-8993(99)02439-7","article-title":"Sodium valproate inhibits production of TNF-\u03b1 and IL-6 and activation of NF-\u039ab","volume":"857","author":"Ichiyama","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2014.01.063_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCULATIONAHA.105.559724","article-title":"Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding","volume":"113","author":"Kee","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2014.01.063_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCULATIONAHA.105.559724","article-title":"Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding","volume":"113","author":"Kee","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2014.01.063_bib19","doi-asserted-by":"crossref","first-page":"H968","DOI":"10.1152\/ajpheart.00891.2006","article-title":"Inhibition of histone deacetylase on ventricular remodeling in infarcted rats","volume":"293","author":"Lee","year":"2007","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.ejphar.2014.01.063_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2014.01.063_bib21","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/01.RES.0000046452.67724.B8","article-title":"Gene expression in \ufb01broblasts and \ufb01brosis: involvement in cardiac hypertrophy","volume":"91","author":"Manabe","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2014.01.063_bib22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2119\/molmed.2011.00022","article-title":"Targeting inflammation in heart failure with histone deacetylase ihibitors","volume":"17","author":"McKinsey","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2014.01.063_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2011.03.043","article-title":"Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis","volume":"145","author":"Mihaylova","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2014.01.063_bib24","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2014.01.063_bib25","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1095\/biolreprod59.6.1425","article-title":"Interleukin 1\u03b1 stimulates lactate dehydrogenase A expression and lactate production in cultured porcine Sertoli cells","volume":"59","author":"Nehar","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2014.01.063_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2014.01.063_bib27","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.lfs.2004.08.018","article-title":"\u03b2-Adrenergic activation reveals impaired cardiac calcium handling at early stage of diabetes","volume":"76","author":"Op den Buijs","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2014.01.063_bib28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/jpet.110.168385","article-title":"Histone deacetylase: a potential therapeutic target for fibrotic disorders","volume":"335","author":"Pang","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2014.01.063_bib29","first-page":"275","article-title":"Oxidative stress and cardiac biomarkers in patients with acute myocardial infarction","volume":"27","author":"Pasupathi","year":"2009","journal-title":"Eur. J. Sci. Res."},{"key":"10.1016\/j.ejphar.2014.01.063_bib30","doi-asserted-by":"crossref","first-page":"17K","DOI":"10.1016\/S0002-9149(03)00774-4","article-title":"High-sensitivity C-reactive protein and cardiovascular risk: rational for screening and primary prevention","volume":"21","author":"Ridker","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2014.01.063_bib31","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.4161\/epi.6.12.18396","article-title":"Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease","volume":"6","author":"Royce","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.ejphar.2014.01.063_bib32","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.2337\/diabetes.50.7.1562","article-title":"Glucagon-like peptide-1 and exendin-4 stimulate b-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age","volume":"50","author":"Tourrel","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2014.01.063_bib33","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1093\/jn\/131.12.3160","article-title":"Linolenic acid restores renal medullary thick ascending limb Na+K+ATPase activity in diabetic rats","volume":"131","author":"Tsimaratos","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.ejphar.2014.01.063_bib34","first-page":"241","article-title":"Emerging targets for diabetes","volume":"88","author":"Vats","year":"2000","journal-title":"Curr. Sci."},{"key":"10.1016\/j.ejphar.2014.01.063_bib35","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/CIRCRESAHA.108.189118","article-title":"New (heat) shocking player in cardiac hypertrophy","volume":"103","author":"Vondriska","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2014.01.063_bib36","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/BF02850226","article-title":"Clinical importance of elevated CK-MB and troponin I levels in congestive heart failure","volume":"23","author":"Yilmaz","year":"2006","journal-title":"Adv. Ther."}],"updated-by":[{"DOI":"10.1016\/j.ejphar.2023.175900","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000}}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:18:56Z","timestamp":1757974736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":36,"alternative-id":["S0014299914000995"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.063","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ejphar.2023.175900","asserted-by":"object"}]},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective effects of magnesium valproate in type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}