{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:02:03Z","timestamp":1774465323999,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81073149"],"award-info":[{"award-number":["81073149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB505304"],"award-info":[{"award-number":["2011CB505304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB518402"],"award-info":[{"award-number":["2012CB518402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific and Technological Major Special Project-Major Creation of New Drugs","award":["2009ZX09501-304"],"award-info":[{"award-number":["2009ZX09501-304"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ejphar.2014.04.050","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T10:18:21Z","timestamp":1401704301000},"page":"273-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Artemisinin protects against dextran sulfate-sodium-induced inflammatory bowel disease, which is associated with activation of the pregnane X receptor"],"prefix":"10.1016","volume":"738","author":[{"given":"Donghua","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengchun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianxie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiande","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengrong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2014.04.050_bib1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s11095-009-9901-7","article-title":"Elucidating the \u2018Jekyll and Hyde\u2019 nature of PXR: the case for discovering antagonists or allosteric antagonists","volume":"26","author":"Biswas","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejphar.2014.04.050_bib2","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1124\/mol.104.009019","article-title":"Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor","volume":"67","author":"Burk","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib3","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1124\/dmd.109.027565","article-title":"Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity","volume":"37","author":"Cheng","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2014.04.050_bib4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.tips.2012.03.003","article-title":"Pregnane X receptor as a target for treatment of inflammatory bowel disorders","volume":"33","author":"Cheng","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2014.04.050_bib5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1124\/jpet.110.170225","article-title":"Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation","volume":"335","author":"Cheng","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2014.04.050_bib6","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ejphar.2014.04.050_bib7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10620-010-1140-6","article-title":"Rifaximin and Crohn\u05f3s disease: a new solution to an old problem?","volume":"55","author":"Day","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2014.04.050_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.mam.2009.04.002","article-title":"Nuclear receptors CAR and PXR: molecular, functional, and biomedical aspects","volume":"30","author":"di Masi","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.ejphar.2014.04.050_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1055\/s-2002-23143","article-title":"Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice","volume":"68","author":"Hong","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2014.04.050_bib10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jep.2013.05.008","article-title":"Up-regulation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn","volume":"148","author":"Huang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1542\/pir.21-9-291","article-title":"Inflammatory bowel disease","volume":"21","author":"Hyams","year":"2000","journal-title":"Pediatr. Rev."},{"key":"10.1016\/j.ejphar.2014.04.050_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ijantimicag.2009.11.013","article-title":"Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei","volume":"35","author":"Jiang","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejphar.2014.04.050_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib14","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.3887571","article-title":"Qinghaosu (artemisinin): an antimalarial drug from China","volume":"228","author":"Klayman","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2014.04.050_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/er.2001-0038","article-title":"The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism","volume":"23","author":"Kliewer","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2014.04.050_bib16","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.bcp.2011.08.023","article-title":"Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene","volume":"82","author":"Krausova","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.gastro.2004.04.019","article-title":"Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes","volume":"127","author":"Langmann","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2014.04.050_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ejphar.2014.04.050_bib19","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1002\/ibd.21585","article-title":"Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease","volume":"17","author":"Long","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ejphar.2014.04.050_bib20","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.bcp.2010.08.022","article-title":"Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells","volume":"80","author":"Mencarelli","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.fct.2012.12.055","article-title":"Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens","volume":"55","author":"Osselaere","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11095-005-8812-5","article-title":"Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans","volume":"23","author":"Persson","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejphar.2014.04.050_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2014.04.050_bib24","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/toxsci\/kfq118","article-title":"Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo","volume":"116","author":"Ross","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2014.04.050_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.taap.2008.12.011","article-title":"Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver","volume":"235","author":"Ross","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib27","doi-asserted-by":"crossref","first-page":"G1114","DOI":"10.1152\/ajpgi.00528.2006","article-title":"Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression","volume":"292","author":"Shah","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib28","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1517\/17425255.2.6.847","article-title":"Pregnane X receptor and natural products: beyond drug\u2013drug interactions","volume":"2","author":"Staudinger","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1046\/j.1365-2125.1999.00044.x","article-title":"Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin","volume":"48","author":"Svensson","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.61.1.1","article-title":"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/MOG.0b013e3283412e87","article-title":"Inflammatory bowel disease and colitis: new concepts from the bench and the clinic","volume":"27","author":"Vermeire","year":"2011","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mc.2940130302","article-title":"Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy","volume":"13","author":"Wacher","year":"1995","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ejphar.2014.04.050_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2008.10.057","article-title":"Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells","volume":"601","author":"Wang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.04.050_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbi.2012.08.023","article-title":"Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury","volume":"200","author":"Wang","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2014.04.050_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.08.004","article-title":"Xenobiotic receptor meets NF-kappaB, a collision in the small bowel","volume":"4","author":"Xie","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2014.04.050_bib37","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.2174\/092986712803251575","article-title":"Immunomodulatory and anti-inflammatory properties of artesunate in experimental colitis","volume":"19","author":"Yang","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2014.04.050_bib38","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1172\/JCI26283","article-title":"Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation","volume":"116","author":"Zhou","year":"2006","journal-title":"J. Clin. Invest."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914003653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914003653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:06:24Z","timestamp":1589241984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914003653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":36,"alternative-id":["S0014299914003653"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.04.050","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artemisinin protects against dextran sulfate-sodium-induced inflammatory bowel disease, which is associated with activation of the pregnane X receptor","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.04.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}