{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:11:58Z","timestamp":1790622718922,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science and Technology Major Projects","award":["2013ZX09J13104-01A"],"award-info":[{"award-number":["2013ZX09J13104-01A"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ejphar.2014.05.044","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T08:10:11Z","timestamp":1401696611000},"page":"153-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Nalmefene reverses carfentanil-induced loss of righting reflex and respiratory depression in rats"],"prefix":"10.1016","volume":"738","author":[{"given":"Zheng","family":"Yong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2014.05.044_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/ALN.0b013e3181c38c25","article-title":"Incidence, reversal, and prevention of opioid-induced respiratory depression","volume":"112","author":"Dahan","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2014.05.044_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/j.1552-4604.1987.tb02191.x","article-title":"Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonist","volume":"27","author":"Dixon","year":"1987","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.05.044_bib3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrn2372","article-title":"General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal","volume":"9","author":"Franks","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2014.05.044_bib4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ajem.2010.03.003","article-title":"Carfentanil-an ultra potent opioid","volume":"28","author":"George","year":"2010","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.ejphar.2014.05.044_bib5","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/cmdc.200700143","article-title":"Mu opioid receptor antagonists: recent developments","volume":"2","author":"Goodman","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejphar.2014.05.044_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neulet.2012.05.042","article-title":"Striatal \u03bc-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects","volume":"521","author":"Hagelberg","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2014.05.044_bib7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0028-3908(85)90100-5","article-title":"Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats","volume":"24","author":"Hurle","year":"1985","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2014.05.044_bib8","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1038\/sj.npp.1300790","article-title":"Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing","volume":"30","author":"Ingman","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2014.05.044_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00000542-197410000-00010","article-title":"Reversal of morphine anesthesia with naloxone","volume":"41","author":"Johnstone","year":"1974","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2014.05.044_bib10","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s40263-013-0101-y","article-title":"Nalmefene: a review of its use in the treatment of alcohol dependence","volume":"27","author":"Keating","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2014.05.044_bib11","first-page":"1726","article-title":"Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system","volume":"38","author":"Kim","year":"1997","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejphar.2014.05.044_bib12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1213\/00000539-197352030-00033","article-title":"Naloxone for antagonism of morphine- induced respiratory depression","volume":"52","author":"Longnecker","year":"1973","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2014.05.044_bib13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jemermed.2009.09.026","article-title":"Human health hazards of veterinary medications: information for emergency departments","volume":"40","author":"Lust","year":"2011","journal-title":"J. Emerg. Med."},{"key":"10.1016\/j.ejphar.2014.05.044_bib14","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.pain.2013.06.026","article-title":"Lack of endogenous opioid release during sustained visceral pain: a [11C]carfentanil PET study","volume":"154","author":"Ly","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2014.05.044_bib15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1001\/archpsyc.56.8.719","article-title":"A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence","volume":"56","author":"Mason","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.05.044_bib16","first-page":"15","article-title":"Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration","volume":"45","author":"Meyer","year":"1984","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.05.044_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.7589\/0090-3558-32.2.234","article-title":"Efficacy and safety of naltrexone hydrochloride for antagonizing carfentanil citrate immobilization in captive Rocky Mountain elk (Cervus elaphus nelsoni)","volume":"32","author":"Miller","year":"1996","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.ejphar.2014.05.044_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1638\/1042-7260(2001)032[0081:UONTRC]2.0.CO;2","article-title":"Use of naloxone to reverse carfentanil citrate-induced hypoxemia and cardiopulmonary depression in Rocky Mountain wapiti (Cervus elaphus nelsoni)","volume":"32","author":"Moresco","year":"2001","journal-title":"J. Zoo Wildl. Med."},{"key":"10.1016\/j.ejphar.2014.05.044_bib19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0014-2999(84)90594-6","article-title":"Different effects of mu and delta opiate agonists on respiration","volume":"98","author":"Morin-Surun","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.05.044_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF01851842","article-title":"A new highly potent and short-acting analgesic, carfentanyl (R33799), in combination with the hypnotic agent, etomidat (R 26490), as a method of anaesthesia in guinea pigs","volume":"177","author":"Neumann","year":"1980","journal-title":"Res. Exp. Med. (Berl.)"},{"key":"10.1016\/j.ejphar.2014.05.044_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.7589\/0090-3558-31.3.391","article-title":"Immobilization of black bears (Ursus americanus) with orally administered carfentanil citrate","volume":"31","author":"Ramsay","year":"1995","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.ejphar.2014.05.044_bib22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/978-0-387-73693-8_85","article-title":"Naloxone reversal of opioid-induced respiratory depression with special emphasis on the partial agonist\/antagonist buprenorphine","volume":"605","author":"Sarton","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2014.05.044_bib23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2460\/javma.1995.206.06.833","article-title":"Complications with the use of carfentanil citrate and xylazine hydrochloride to immobilize domestic horses","volume":"206","author":"Shaw","year":"1995","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.ejphar.2014.05.044_bib24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1517\/13543784.2010.522990","article-title":"Nalmefene for treatment of alcohol dependence","volume":"19","author":"Soyka","year":"2010","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.ejphar.2014.05.044_bib25","first-page":"CD001867","article-title":"Opioid antagonists for alcohol dependence","volume":"2","author":"Srisurapanont","year":"2002","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2014.05.044_bib26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1638\/05-079.1","article-title":"Effects of ketamine on carfentanil and xylazine immobilization of white-tailed deer (Odocoileus virginianus)","volume":"37","author":"Storms","year":"2006","journal-title":"J. Zoo Wildl. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914004063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914004063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:39:01Z","timestamp":1716791941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914004063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":26,"alternative-id":["S0014299914004063"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.05.044","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nalmefene reverses carfentanil-induced loss of righting reflex and respiratory depression in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.05.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}