{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:40:19Z","timestamp":1784590819887,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["6959229\/2013"],"award-info":[{"award-number":["6959229\/2013"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PNPD 2536\/2011"],"award-info":[{"award-number":["PNPD 2536\/2011"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Edital INCT 573928\/2008-8"],"award-info":[{"award-number":["Edital INCT 573928\/2008-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ejphar.2014.07.016","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T04:47:38Z","timestamp":1405658858000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Antispasmodic and myorelaxant effects of the flavoring agent methyl cinnamate in gut: Potential inhibition of tyrosine kinase"],"prefix":"10.1016","volume":"740","author":[{"given":"Francisco J.B.","family":"Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cosker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresinha S.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lder V.","family":"Ribeiro-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M.S.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline S.","family":"Arag\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Lahlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellus H.L.P.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arm\u00eanio A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.C.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2014.07.016_bib1","doi-asserted-by":"crossref","first-page":"14560","DOI":"10.1073\/pnas.222348099","article-title":"Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction","volume":"99","author":"Alioua","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2014.07.016_bib2","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","article-title":"Genistein, a specific inhibitor of tyrosine-specific protein kinases","volume":"262","author":"Akiyama","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2014.07.016_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fitote.2009.10.002","article-title":"Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties","volume":"81","author":"Ballabeni","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejphar.2014.07.016_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.fct.2007.09.077","article-title":"Fragrance material review on methyl cinnamate","volume":"45","author":"Bhatia","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib5","first-page":"2879","article-title":"Membrane potential and excitation-contraction coupling in smooth muscle","volume":"41","author":"Casteels","year":"1982","journal-title":"Fed. Proc."},{"key":"10.1016\/j.ejphar.2014.07.016_bib6","doi-asserted-by":"crossref","first-page":"G849","DOI":"10.1152\/ajpgi.00530.2004","article-title":"Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles","volume":"288","author":"Gerthoffer","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1980.sp013281","article-title":"Effects of tetraethylammonium chloride on contractile, membrane and cable properties of rabbit artery muscle","volume":"303","author":"Haeusler","year":"1980","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib8","doi-asserted-by":"crossref","first-page":"28195","DOI":"10.1074\/jbc.M113.474114","article-title":"Discovery of novel irreversible Inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket","volume":"288","author":"Harling","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2014.07.016_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/bjp.2008.91","article-title":"Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea-pig stomach","volume":"154","author":"Hashitani","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib10","doi-asserted-by":"crossref","first-page":"C1780","DOI":"10.1152\/ajpcell.1996.270.6.C1780","article-title":"Tyrosine kinase-dependent modulation of calcium entry in rabbit colonic muscularis mucosae","volume":"270","author":"Hatakeyama","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib11","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1021\/jf8036227","article-title":"Inhibitory effects of methyl trans-cinnamate on mushroom tyrosinase and its antimicrobial activities","volume":"57","author":"Huang","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2014.07.016_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(95)00053-N","article-title":"Alpha 2-adrenoceptor-mediated vasoconstriction requires a tyrosine kinase","volume":"277","author":"Jinsi","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib13","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.3748\/wjg.v13.i42.5581","article-title":"Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease","volume":"13","author":"Kawada","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1152\/ajpgi.00038.2003","article-title":"Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn\u05f3s colitis model","volume":"285","author":"Kinoshita","year":"2003","journal-title":"Am .J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1476-5381.1994.tb17003.x","article-title":"Regulation of vascular and gastric smooth muscle contractility by pervanadate","volume":"113","author":"Laniyonu","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib16","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/gut.28.9.1095","article-title":"In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis","volume":"28","author":"Lauritsen","year":"1987","journal-title":"Gut"},{"issue":"13","key":"10.1016\/j.ejphar.2014.07.016_bib17","article-title":"Anti-inflammatory effects of methyl cinnamate, the major constituent of the essential oil of Ocimum micranthum, on the gastrointestinal tract of rats submitted to acetic acid-induced colitis","volume":"79","author":"Lima","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2014.07.016_bib18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/FJC.0b013e31813542bd","article-title":"Role of tyrosine phosphorylation in U46619-induced vasoconstriction of pulmonary vasculature and its modulation by genistein, daidzein, and equol","volume":"50","author":"Liu","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/50300547","article-title":"Antiinflammatory activity of cinnamic acid esters","volume":"5","author":"Godoy","year":"2000","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2014.07.016_bib20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1472-8206.2004.00276.x","article-title":"Antispasmodic effects of the essential oil of Croton nepetaefolius on guinea-pig ileum: a myogenic activity","volume":"18","author":"Magalh\u00e3es","year":"2004","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2006.06.068","article-title":"Imatinib inhibits spontaneous rhythmic contractions of human uterus and intestine","volume":"546","author":"Popescu","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib22","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1476-5381.1990.tb14151.x","article-title":"Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo","volume":"101","author":"Rees","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"13","key":"10.1016\/j.ejphar.2014.07.016_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1152\/advan.00050.2012","article-title":"Talking about bioelectrical potentials using rings of the mesenteric artery without glass micropipettes","volume":"36","author":"Ribeiro-Filho","year":"2012","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.ejphar.2014.07.016_bib24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.physiol.68.040504.094718","article-title":"Interstitial cells of cajal as pacemakers in the gastrointestinal tract","volume":"68","author":"Sanders","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib25","doi-asserted-by":"crossref","first-page":"G899","DOI":"10.1152\/ajpgi.00408.2003","article-title":"G protein-mediated dysfunction of excitation-contraction coupling in ileal inflammation","volume":"286","author":"Shi","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/mnfr.200600202","article-title":"Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale","volume":"51","author":"Siddaraju","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejphar.2014.07.016_bib27","doi-asserted-by":"crossref","first-page":"G61","DOI":"10.1152\/ajpgi.00100.2002","article-title":"Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells","volume":"282","author":"Singer","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib28","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2014.07.016_bib29","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1101\/gad.1964410","article-title":"Inhibition of RIP2\u05f3s tyrosine kinase activity limits NOD2-driven cytokine responses","volume":"24","author":"Tigno-Aranjuez","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2014.07.016_bib30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.7164\/antibiotics.39.170","article-title":"Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3","volume":"39","author":"Umezawa","year":"1986","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.ejphar.2014.07.016_bib31","first-page":"H614","article-title":"KCl depolarization increases Ca2+ sensitivity of contractile elements in coronary arterial smooth muscle","volume":"267","author":"Yanagisawa","year":"1994","journal-title":"Am .J. Physiol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1139\/y92-012","article-title":"Tyrosine kinase inhibitors and the contractile action of epidermal growth factor-urogastrone and other agonists in gastric smooth muscle","volume":"70","author":"Yang","year":"1992","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.016_bib33","first-page":"817","article-title":"Synthesis, antiinflammatory and anticancer activity of cinnamic acids, their derivatives and analogs","volume":"27","author":"Zhang","year":"1992","journal-title":"Acta Pharm. Sin."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914005536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914005536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T17:14:00Z","timestamp":1764263640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914005536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":33,"alternative-id":["S0014299914005536"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.016","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antispasmodic and myorelaxant effects of the flavoring agent methyl cinnamate in gut: Potential inhibition of tyrosine kinase","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}