{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:50:35Z","timestamp":1790016635245,"version":"4.0.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001850","name":"Department of Chemicals and Petrochemicals, Ministry of Chemicals and Fertilizers, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ejphar.2014.07.031","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T13:04:09Z","timestamp":1406120649000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"special_numbering":"C","title":["Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice"],"prefix":"10.1016","volume":"740","author":[{"given":"Ashok","family":"Jangra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish M.","family":"Lukhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjbihari","family":"Sulakhiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandana C.","family":"Baruah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangala","family":"Lahkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2014.07.031_bib1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ptr.859","article-title":"Evaluation of the antidiabetic action of Mangifera indica in mice","volume":"15","author":"Aderibigbe","year":"2001","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib2","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1128\/IAI.70.11.6068-6074.2002","article-title":"Corticotropin-releasing hormone augments proinflammatory cytokine production from macrophages in vitro and in lipopolysaccharide-induced endotoxin shock in mice","volume":"70","author":"Agelaki","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2014.07.031_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1742-7843.2011.00824.x","article-title":"Lipopolysaccharide\u2010induced sickness behaviour evaluated in different models of anxiety and innate fear in rats","volume":"110","author":"Bassi","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0889-1591(03)00113-2","article-title":"Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behaviour in mice","volume":"18","author":"Berg","year":"2004","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2014.07.031_bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2008.04.022","article-title":"N-acetyl cysteine for depressive symptoms in bipolar disorder\u2014a double-blind randomized placebo-controlled trial","volume":"64","author":"Berk","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib6","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2014.07.031_bib7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/BF00609562","article-title":"Monoamine oxidase-inhibiting activity of mangiferin isolated from Canscora decussata","volume":"59","author":"Bhattacharya","year":"1972","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.ejphar.2014.07.031_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/271359","article-title":"Systemic immune activation leads to neuroinflammation and sickness behavior in mice","author":"Biesmans","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2014.07.031_bib9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2012.02.042","article-title":"Neuropharmacological effect of mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer\u05f3s disease","volume":"683","author":"Biradar","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2010.09.049","article-title":"Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress","volume":"1363","author":"Chung","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2\u2013NF\u03baB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ejphar.2014.07.031_bib12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.neuro.2007.07.008","article-title":"Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: effects of sub acute vitamin A supplementation at therapeutic doses","volume":"28","author":"De Oliveira","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ejphar.2014.07.031_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0003-9861(02)00064-4","article-title":"Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine","volume":"402","author":"Dikalov","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2014.07.031_bib14","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib15","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1017\/S0033291700038629","article-title":"Neopterin measurement provides evidence of altered cell-mediated immunity in patients with depression, but not with schizophrenia","volume":"22","author":"Dunbar","year":"1992","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ejphar.2014.07.031_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0166-4328(97)02286-9","article-title":"Effects of weekly or daily exposure to the elevated plus-maze in male mice","volume":"87","author":"Espejo","year":"1997","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/1099-1573(200102)15:1<18::AID-PTR676>3.0.CO;2-R","article-title":"Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang)","volume":"15","author":"Garrido","year":"2001","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib18","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jpsychires.2012.06.008","article-title":"Oxidative stress and glutathione response in tissue cultures from persons with major depression","volume":"46","author":"Gibson","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib19","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1096\/fj.05-3776fje","article-title":"Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system","volume":"19","author":"Godbout","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2014.07.031_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2014.07.031_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbi.2005.04.005","article-title":"Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats","volume":"20","author":"Guan","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2014.07.031_bib22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000239478","article-title":"Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone","volume":"42","author":"Guha","year":"1996","journal-title":"Chemotherapy"},{"key":"10.1016\/j.ejphar.2014.07.031_bib23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00124509-200312000-00002","article-title":"Raised plasma levels of tumor necrosis factor [alpha] in patients with depression: normalization during electroconvulsive therapy","volume":"19","author":"Hestad","year":"2003","journal-title":"J. ECT"},{"key":"10.1016\/j.ejphar.2014.07.031_bib24","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1139\/cjpp-2013-0090","article-title":"Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats","volume":"91","author":"Hou","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib25","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.neurobiolaging.2007.04.012","article-title":"Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide","volume":"29","author":"Huang","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2014.07.031_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-1781(02)00005-7","article-title":"Decreased serum brain-derived neurotrophic factor levels in major depressed patients","volume":"109","author":"Karege","year":"2002","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0889-1591(02)00077-6","article-title":"Cytokine-induced sickness behavior","volume":"17","author":"Kelley","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2014.07.031_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2009.03.068","article-title":"Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory","volume":"456","author":"Koo","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2014.07.031_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0006-8993(98)01288-8","article-title":"Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxiogenic-like effects","volume":"818","author":"Lacosta","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1742-2094-10-87","article-title":"Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2, 3-dioxygenase-dependent depression-like behaviors","volume":"10","author":"Lawson","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2014.07.031_bib31","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1152\/ajpregu.2000.279.1.R93","article-title":"Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression","volume":"279","author":"Lay\u00e9","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4306\/pi.2010.7.4.231","article-title":"The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment","volume":"7","author":"Lee","year":"2010","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.ejphar.2014.07.031_bib33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-0447.1999.tb07221.x","article-title":"Psychomotor retardation and anhedonia in depression","volume":"99","author":"Lemke","year":"1999","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ejphar.2014.07.031_bib34","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2014.07.031_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2014.07.031_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0278-5846(94)00101-M","article-title":"Evidence for an immune response in major depression: a review and hypothesis","volume":"19","author":"Maes","year":"1995","journal-title":"Prog. NeuroPsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib37","first-page":"287","article-title":"The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression","volume":"29","author":"Maes","year":"2008","journal-title":"Neuro. Endocrinol. Lett."},{"key":"10.1016\/j.ejphar.2014.07.031_bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib39","first-page":"715","article-title":"Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"30","author":"Maes","year":"2008","journal-title":"Neuro. Endocrinol. Lett."},{"key":"10.1016\/j.ejphar.2014.07.031_bib40","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00394-011-0252-x","article-title":"Mangiferin decreases inflammation and oxidative damage in rat brain after stress","volume":"51","author":"M\u00e1rquez","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ejphar.2014.07.031_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-0-585-37970-8_2","article-title":"Major depression and activation of the inflammatory response system","volume":"461","author":"Maes","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/2193-1801-2-165","article-title":"Effect of dietary fat type on anxiety-like and depression-like behavior in mice","volume":"2","author":"Mizunoya","year":"2013","journal-title":"SpringerPlus"},{"key":"10.1016\/j.ejphar.2014.07.031_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2014.07.031_bib44","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejphar.2014.07.031_bib45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2014.07.031_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib47","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S1734-1140(12)70879-4","article-title":"Mangiferin ameliorates 6-hydroxydopamine-induced cytotoxicity and oxidative stress in ketamine model of schizophrenia","volume":"64","author":"Rao","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2014.07.031_bib48","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0306-4530(01)00101-9","article-title":"Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-\u03b1 and IL-6 secretion","volume":"27","author":"Reichenberg","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2014.07.031_bib49","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.yhbeh.2006.06.019","article-title":"Role of corticotropin releasing factor in anxiety disorders: a translational research perspective","volume":"50","author":"Risbrough","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ejphar.2014.07.031_bib50","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/0253-7613.77365","article-title":"Effect of quercetin on lipopolysaccharide induced-sickness behavior and oxidative stress in rats","volume":"43","author":"Sah","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib51","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.yhbeh.2012.03.010","article-title":"Indoleamine 2, 3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge","volume":"62","author":"Salazar","year":"2012","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ejphar.2014.07.031_bib52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbr.2009.12.039","article-title":"Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats","volume":"208","author":"Salim","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib53","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.biopsych.2008.05.005","article-title":"Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications","volume":"64","author":"Sen","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib54","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.biopsych.2005.10.013","article-title":"TNF\u03b1 signaling in depression and anxiety: behavioral consequences of individual receptor targeting","volume":"59","author":"Simen","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib55","first-page":"126","article-title":"Phytochemical and pharmacological investigations on mangiferin","volume":"55","author":"Singh","year":"2009","journal-title":"Herba Polonica"},{"key":"10.1016\/j.ejphar.2014.07.031_bib56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0165-1781(96)02783-7","article-title":"Indicators of immune activation in major depression","volume":"64","author":"Sluzewska","year":"1996","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib57","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2014.07.031_bib58","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0165-0327(00)00164-6","article-title":"Elevated plasma nitrate levels in depressive states","volume":"63","author":"Suzuki","year":"2001","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2014.07.031_bib59","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.etap.2008.10.003","article-title":"A comparative study on oxidative stress induced by LPS and rotenone in homogenates of rat brain regions","volume":"27","author":"Swarnkar","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejphar.2014.07.031_bib60","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.pbb.2007.02.010","article-title":"Effects of interleukin-1\u03b2 and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests","volume":"86","author":"Swiergiel","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2014.07.031_bib61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(97)01009-3","article-title":"The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra)","volume":"776","author":"Swiergiel","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2014.07.031_bib62","doi-asserted-by":"crossref","first-page":"S397","DOI":"10.4103\/0019-5545.116311","article-title":"Low serum brain derived neurotrophic factor in non-suicidal out-patients with depression: relation to depression scores","volume":"55","author":"Varambally","year":"2013","journal-title":"Indian J. Psychiatry"},{"key":"10.1016\/j.ejphar.2014.07.031_bib63","first-page":"1798","article-title":"Effects of mangiferin on MAPK signaling pathway in chronic inflammation","volume":"36","author":"Wei","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.ejphar.2014.07.031_bib64","unstructured":"World Health Organization. (2012). Retrieved from \u3008http:\/\/www.who.int\/mediacentre\/factsheets\/fs369\/en\/\u3009."},{"key":"10.1016\/j.ejphar.2014.07.031_bib65","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbr.2008.06.030","article-title":"Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats","volume":"194","author":"Zhao","year":"2008","journal-title":"Behav. Brain Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914005688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299914005688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T17:15:37Z","timestamp":1764263737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299914005688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":65,"alternative-id":["S0014299914005688"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.031","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}