{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:30:38Z","timestamp":1783517438593,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health\u05f3s","doi-asserted-by":"crossref","award":["# HHSN-271-2008-00025-C"],"award-info":[{"award-number":["# HHSN-271-2008-00025-C"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA034806"],"award-info":[{"award-number":["R01DA034806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21DA033426"],"award-info":[{"award-number":["R21DA033426"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.ejphar.2015.01.013","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T23:16:49Z","timestamp":1421882209000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats"],"prefix":"10.1016","volume":"749","author":[{"given":"Yanyan","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.01.013_bib1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.pbb.2012.01.024","article-title":"Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats","volume":"101","author":"An","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2015.01.013_bib2","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1476-5381.1995.tb16656.x","article-title":"RS-45041-190: a selective, high-affinity ligand for I2 imidazoline receptors","volume":"116","author":"Brown","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neulet.2009.11.018","article-title":"Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats","volume":"468","author":"Chang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2015.01.013_bib4","first-page":"182846","article-title":"Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents","volume":"2014","author":"Chen","year":"2014","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ejphar.2015.01.013_bib5","first-page":"154","article-title":"Intrinsic activity and discriminative effects of drugs","volume":"4","author":"Colpaert","year":"1988","journal-title":"Psychopharmacol. Ser."},{"key":"10.1016\/j.ejphar.2015.01.013_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0091-3057(99)00047-7","article-title":"Drug discrimination in neurobiology","volume":"64","author":"Colpaert","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2015.01.013_bib7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0028-3908(80)90061-1","article-title":"Factors regulating drug cue sensitivity: the effect of training dose in fentanyl-saline discrimination","volume":"19","author":"Colpaert","year":"1980","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2015.01.013_bib8","first-page":"145","article-title":"Training dose: influences in opioid drug discrimination","author":"Comer","year":"1991","journal-title":"NIDA Res. Monogr."},{"key":"10.1016\/j.ejphar.2015.01.013_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2014.03.047","article-title":"(S)-amisulpride as a discriminative stimulus in C57BL\/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics","volume":"734","author":"Donahue","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0165-6147(98)01244-9","article-title":"\u05f3Seeing through a glass darkly\u05f3: casting light on imidazoline \u05f3I\u05f3 sites","volume":"19","author":"Eglen","year":"1998","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2015.01.013_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(87)90125-7","article-title":"Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla","volume":"134","author":"Ernsberger","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib12","first-page":"111","article-title":"Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain","volume":"4","author":"Ferrari","year":"2011","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ejphar.2015.01.013_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2006.09.031","article-title":"Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects","volume":"553","author":"Gentili","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1749-6632.1999.tb09344.x","article-title":"Novel selective compounds for the investigation of imidazoline receptors","volume":"881","author":"Hudson","year":"1999","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejphar.2015.01.013_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/026988119601000403","article-title":"Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI","volume":"10","author":"Jordan","year":"1996","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2009.04.044","article-title":"Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site","volume":"1279","author":"Kimura","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2015.01.013_bib17","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1111\/bph.12728","article-title":"Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats","volume":"171","author":"Lanza","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib18","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1037\/1064-1297.8.3.294","article-title":"Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines","volume":"8","author":"Lelas","year":"2000","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1126\/science.7906055","article-title":"Agmatine: an endogenous clonidine-displacing substance in the brain","volume":"263","author":"Li","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.01.013_bib43","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1124\/jpet.109.157560","article-title":"Discriminative stimulus effects of DOM, ketanserin and MDL100907 in rats","volume":"331","author":"Li","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.01.013_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ejphar.2012.10.037","article-title":"The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats","volume":"698","author":"Li","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib21","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/bph.12555","article-title":"Antihyperalgesic effects of imidazoline I(2) receptor ligands in rat models of inflammatory and neuropathic pain","volume":"171","author":"Li","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2011.02.038","article-title":"Imidazoline I2 receptors: target for new analgesics?","volume":"658","author":"Li","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2011.07.041","article-title":"Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I(2) receptor ligands","volume":"669","author":"Li","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib24","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/sj.bjp.0706019","article-title":"Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway","volume":"143","author":"Macinnes","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib25","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/sj.bjp.0704579","article-title":"Characterization of the discriminable stimulus produced by 2-BFI: effects of imidazoline I(2)-site ligands, MAOIs, beta-carbolines, agmatine and ibogaine","volume":"135","author":"MacInnes","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0091-3057(03)00136-9","article-title":"Potential serotonergic and noradrenergic involvement in the discriminative stimulus effects of the selective imidazoline I2-site ligand 2-BFI","volume":"75","author":"MacInnes","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2015.01.013_bib27","first-page":"151","article-title":"CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats","volume":"5","author":"Meregalli","year":"2012","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ejphar.2015.01.013_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejphar.2013.09.016","article-title":"Gender difference in epileptogenic effects of 2-BFI and BU224 in mice","volume":"718","author":"Min","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1749-6632.1999.tb09354.x","article-title":"Pharmacologic and molecular discrimination of I2-imidazoline receptor subtypes","volume":"881","author":"Olmos","year":"1999","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejphar.2015.01.013_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-6147(96)81564-1","article-title":"The elusive family of imidazoline binding sites","volume":"17","author":"Parini","year":"1996","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2015.01.013_bib31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0968-0896(97)00009-6","article-title":"Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity","volume":"5","author":"Pigini","year":"1997","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.01.013_bib32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00213-008-1308-3","article-title":"Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studies","volume":"203","author":"Porter","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2015.01.013_bib33","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1038\/srep06605","article-title":"Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats","volume":"4","author":"Qiu","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2015.01.013_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FBP.0000000000000028","article-title":"Behavioral effects of the imidazoline I(2) receptor ligand BU99006 in rats","volume":"25","author":"Qiu","year":"2014","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib35","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sj.bjp.0705052","article-title":"Attenuation of acute and chronic effects of morphine by the imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline in rat locus coeruleus neurons","volume":"138","author":"Ruiz-Durantez","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/sj.bjp.0703294","article-title":"Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors","volume":"130","author":"Sanchez-Blazquez","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib37","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1111\/j.1476-5381.2012.01894.x","article-title":"Characterization of the hypothermic effects of imidazoline I(2) receptor agonists in rats","volume":"166","author":"Thorn","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ejphar.2011.09.173","article-title":"Effects of imidazoline I(2) receptor ligands on morphine- and tramadol-induced antinociception in rats","volume":"670","author":"Thorn","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.013_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pnpbp.2011.11.005","article-title":"The potential antidepressant-like effect of imidazoline I2 ligand 2-BFI in mice","volume":"37","author":"Tonello","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.01.013_bib40","first-page":"359","article-title":"Mediation of AMP kinase in the increase of glucose uptake in L6 cells induced by activation of imidazoline I-2 receptors","volume":"45","author":"Yang","year":"2013","journal-title":"Horm. Metab. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915000357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915000357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T01:00:02Z","timestamp":1537923602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915000357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":41,"alternative-id":["S0014299915000357"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.01.013","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}