{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:12:55Z","timestamp":1759961575057,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003336","name":"Bulgarian National Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ejphar.2015.01.045","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T11:57:43Z","timestamp":1423310263000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock"],"prefix":"10.1016","volume":"751","author":[{"given":"Valeriya","family":"Gyurkovska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Ivanovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.01.045_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11882-004-0084-3","article-title":"Complement-induced impairment of the innate immune system during sepsis","volume":"4","author":"Albrecht","year":"2004","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.ejphar.2015.01.045_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ceb.2009.01.015","article-title":"Targeting protein kinases for the development of anti-inflammatory drugs","volume":"21","author":"Cohen","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1021\/cb300610s","article-title":"Kinase drug discovery\u2014what\u05f3s next in the field?","volume":"8","author":"Cohen","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib4","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/10512","article-title":"Protective effects of C5a blockade in sepsis","volume":"5","author":"Czermak","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2015.01.045_bib5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak\u2013STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.01.045_bib6","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.2174\/0929867054546645","article-title":"STAT1 as a new molecular target of anti-inflammatory treatment","volume":"12","author":"de Prati","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.01.045_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1476-9255-6-13","article-title":"Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490","volume":"6","author":"Dimitrova","year":"2009","journal-title":"J. Inflamm."},{"key":"10.1016\/j.ejphar.2015.01.045_bib8","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.intimp.2008.06.013","article-title":"Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation","volume":"8","author":"Dimitrova","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1574-695X.2008.00421.x","article-title":"Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNA","volume":"53","author":"Dimitrova","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib10","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/infdis\/163.6.1177","article-title":"The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome","volume":"163","author":"Dinarello","year":"1991","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejphar.2015.01.045_bib11","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.4049\/jimmunol.151.5.2717","article-title":"Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages","volume":"151","author":"Dong","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib12","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1164\/rccm.200204-302OC","article-title":"Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis","volume":"166","author":"Eichacker","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.01.045_bib13","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.4049\/jimmunol.171.6.3119","article-title":"Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology","volume":"171","author":"Higgins","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib14","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.4049\/jimmunol.169.6.3223","article-title":"Complement-induced impairment of innate immunity during sepsis","volume":"169","author":"Huber-Lang","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib15","first-page":"859","article-title":"Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality","volume":"66","author":"Hui","year":"2009","journal-title":"J. Trauma"},{"key":"10.1016\/j.ejphar.2015.01.045_bib16","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1128\/IAI.73.3.1754-1763.2005","article-title":"Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury","volume":"73","author":"Jeyaseelan","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2015.01.045_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2172-13-69","article-title":"CD11b+Ly6C++Ly6G\u2212 cells show distinct function in mice with chronic inflammation or tumor burden","volume":"13","author":"Kallberg","year":"2012","journal-title":"BMC Immunol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0041-1345(00)02791-3","article-title":"Tyrphostin AG490 selectively inhibits activation of the JAK3\/STAT5\/MAPK pathway and rejection of rat heart allografts","volume":"33","author":"Kirken","year":"2001","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.ejphar.2015.01.045_bib19","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.01.045_bib20","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/j.1582-4934.2008.00504.x","article-title":"Complexity of complement activation in sepsis","volume":"12","author":"Markiewski","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2015.01.045_bib21","first-page":"239","article-title":"STAT proteins in innate immunity during sepsis: lessons from gene knockout mice","volume":"61","author":"Matsukawa","year":"2007","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.ejphar.2015.01.045_bib22","first-page":"189","article-title":"Serum complement levels and severity of sepsis","volume":"84","author":"Nakae","year":"1994","journal-title":"Res. Commun. Pathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.7326\/0003-4819-120-9-199405010-00009","article-title":"Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis","volume":"120","author":"Natanson","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2015.01.045_bib24","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1016\/S0021-9258(17)36703-0","article-title":"Regulation of biosynthesis of nitric oxide","volume":"269","author":"Nathan","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.01.045_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2567.2004.01976.x","article-title":"Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4","volume":"113","author":"Palsson-McDermott","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2015.01.045_bib26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00109-010-0628-z","article-title":"JAK2 inhibition prevents innate immune responses and rescues animals from sepsis","volume":"88","author":"Pena","year":"2010","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.ejphar.2015.01.045_bib27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00024382-200206000-00004","article-title":"Six at six: interleukin-6 measured 6h after the initiation of sepsis predicts mortality over 3 days","volume":"17","author":"Remick","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2015.01.045_bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00024382-200013020-00004","article-title":"Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture","volume":"13","author":"Remick","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2015.01.045_bib29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","article-title":"Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression","volume":"170","author":"Riedemann","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.bjp.0701345","article-title":"Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase","volume":"122","author":"Ruetten","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/09629359990568","article-title":"Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase: comparison to induction of iNOS","volume":"8","author":"Ruetten","year":"1999","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2015.01.045_bib32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK\u2013STAT pathway at twenty","volume":"36","author":"Stark","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2015.01.045_bib33","first-page":"579","article-title":"An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mucosa","volume":"93","author":"Terres","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2015.01.045_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00024382-199711000-00006","article-title":"Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis","volume":"8","author":"Zisman","year":"1997","journal-title":"Shock"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915000783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915000783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:21:02Z","timestamp":1757974862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915000783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":34,"alternative-id":["S0014299915000783"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.01.045","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.01.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}