{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:10Z","timestamp":1788870250138,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30971225"],"award-info":[{"award-number":["30971225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470551"],"award-info":[{"award-number":["81470551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300206"],"award-info":[{"award-number":["81300206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"crossref","award":["2012KYQ09"],"award-info":[{"award-number":["2012KYQ09"]}],"id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.ejphar.2015.02.039","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T13:50:09Z","timestamp":1425390609000},"page":"102-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K"],"prefix":"10.1016","volume":"755","author":[{"given":"Lu","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.02.039_bib1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0008-6363(01)00220-6","article-title":"Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells","volume":"50","author":"Bond","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2015.02.039_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm763","article-title":"Matrix metalloproteinases: a tail of a frog that became a prince","volume":"3","author":"Brinckerhoff","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/2049-632X.12185","article-title":"Chlamydia pneumoniae infection of lungs and macrophages indirectly stimulates the phenotypic conversion of smooth muscle cells and mesenchymal stem cells: potential roles in vascular calcification and fibrosis","volume":"72","author":"Cabbage","year":"2014","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.ejphar.2015.02.039_bib4","first-page":"1","article-title":"Chlamydia pneumoniae induces expression of pro-atherogenic factors through activation of the lectin-like oxidized LDL receptor-1","volume":"69","author":"Campbell","year":"2013","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.ejphar.2015.02.039_bib5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/jphp.12026","article-title":"Effects of berberine on rat jejunal motility","volume":"65","author":"Chen","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3892\/ijmm.2014.1748","article-title":"Berberine combined with atorvastatin downregulates LOX1 expression through the ET1 receptor in monocyte\/macrophages","volume":"34","author":"Chi","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2015.02.039_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/emm.2002.56","article-title":"Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis","volume":"34","author":"Choi","year":"2002","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2015.02.039_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1046\/j.1462-5822.2002.00203.x","article-title":"Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells","volume":"4","author":"Coombes","year":"2002","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib9","first-page":"1855","article-title":"Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association","volume":"61","author":"Ellerbroek","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2015.02.039_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2009.01.033","article-title":"Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9","volume":"279","author":"Ho","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2015.02.039_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbi.2009.05.009","article-title":"Inhibitory effect of penta-acetyl geniposide on C6 glioma cells metastasis by inhibiting matrix metalloproteinase-2 expression involved in both the PI3K and ERK signaling pathways","volume":"181","author":"Huang","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2015.02.039_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1586\/14779072.5.2.265","article-title":"Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability","volume":"5","author":"Johnson","year":"2007","journal-title":"Expert. Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.ejphar.2015.02.039_bib13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4049\/jimmunol.1300481","article-title":"MAPK kinase 3 potentiates Chlamydia HSP60-induced inflammatory response through distinct activation of NF-kappaB","volume":"191","author":"Kang","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib14","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1161\/01.CIR.96.10.3555","article-title":"Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9","volume":"96","author":"Kenagy","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2015.02.039_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bcp.2011.11.008","article-title":"Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression","volume":"83","author":"Kim","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.canlet.2010.03.012","article-title":"Decursinol angelate blocks transmigration and inflammatory activation of cancer cells through inhibition of PI3K, ERK and NF-kappaB activation","volume":"296","author":"Kim","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2015.02.039_bib17","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2015.02.039_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrm3861","article-title":"Steering cell migration: lamellipodium dynamics and the regulation of directional persistence","volume":"15","author":"Krause","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2005.06.048","article-title":"Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model","volume":"186","author":"Lee","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2015.02.039_bib20","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","article-title":"Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states","volume":"55","author":"Lee","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2015.02.039_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ejphar.2008.06.034","article-title":"Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells","volume":"590","author":"Liang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib22","doi-asserted-by":"crossref","first-page":"e21416","DOI":"10.1371\/journal.pone.0021416","article-title":"Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2015.02.039_bib23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5483\/BMBRep.2014.47.7.186","article-title":"Berberine suppresses in vitro migration of human aortic smooth muscle cells through the inhibitions of MMP-2\/9, u-PA, AP-1, and NF-kappaB","volume":"47","author":"Liu","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.ejphar.2015.02.039_bib24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/jsre.2000.5847","article-title":"Chlamydia pneumoniae activates nuclear factor kappaB and activator protein 1 in human vascular smooth muscle and induces cellular proliferation","volume":"90","author":"Miller","year":"2000","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2015.02.039_bib25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/ptr.3353","article-title":"Baekjeolyusin-tang and its active component berberine block the release of collagen and proteoglycan from IL-1beta-stimulated rabbit cartilage and down-regulate matrix metalloproteinases in rabbit chondrocytes","volume":"25","author":"Moon","year":"2011","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2015.02.039_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00048.2003","article-title":"Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture","volume":"85","author":"Newby","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2015.02.039_bib27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cardiores.2005.08.002","article-title":"Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates","volume":"69","author":"Newby","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2015.02.039_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/039463201202500207","article-title":"Induction of VEGF and MMP-9 expression by toll-like receptor 2\/4 in human endothelial cells infected with Chlamydia pneumoniae","volume":"25","author":"Paolillo","year":"2012","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4168\/aair.2010.2.1.41","article-title":"Chlamydophila pneumoniae enhances secretion of VEGF, TGF-beta and TIMP-1 from human bronchial epithelial cells under Th2 dominant microenvironment","volume":"2","author":"Park","year":"2010","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.ejphar.2015.02.039_bib30","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.4049\/jimmunol.167.6.3316","article-title":"Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells","volume":"167","author":"Prebeck","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0928-8244(03)00126-3","article-title":"Increased production of matrix metalloproteinases 1 and 3 by smooth muscle cells upon infection with Chlamydia pneumoniae","volume":"38","author":"Rodel","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1160\/TH05-07-0465","article-title":"EMMPRIN (CD 147) is a central activator of extracellular matrix degradation by Chlamydia pneumoniae-infected monocytes. Implications for plaque rupture","volume":"95","author":"Schmidt","year":"2006","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ejphar.2015.02.039_bib33","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1172\/JCI119472","article-title":"Perspectives series: cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis","volume":"99","author":"Schwartz","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2015.02.039_bib34","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0955-0674(02)00363-0","article-title":"The cell surface: the stage for matrix metalloproteinase regulation of migration","volume":"14","author":"Seiki","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2014.07.039","article-title":"FoxO proteins\u2019 nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells","volume":"76C","author":"Shukla","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2015.02.039_bib36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/215527a0","article-title":"Effect of berberine sulphate on Entamoeba histolytica","volume":"215","author":"Subbaiah","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2015.02.039_bib37","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1128\/IAI.01087-13","article-title":"Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration through a Toll-like receptor 2-related signaling pathway","volume":"81","author":"Wang","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2015.02.039_bib38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/1534735410379121","article-title":"F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration","volume":"9","author":"Wang","year":"2010","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.ejphar.2015.02.039_bib39","doi-asserted-by":"crossref","first-page":"e25436","DOI":"10.1371\/journal.pone.0025436","article-title":"Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2015.02.039_bib40","doi-asserted-by":"crossref","first-page":"H2861","DOI":"10.1152\/ajpheart.00230.2004","article-title":"Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP","volume":"287","author":"Zahradka","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2015.02.039_bib41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.micpath.2012.07.005","article-title":"Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1","volume":"53","author":"Zhang","year":"2012","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ejphar.2015.02.039_bib42","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12275-011-1051-z","article-title":"Berberine inhibits HEp-2 cell invasion induced by Chlamydophila pneumoniae infection","volume":"49","author":"Zhang","year":"2011","journal-title":"J. Microbiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915001582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915001582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T20:36:18Z","timestamp":1589488578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915001582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":42,"alternative-id":["S0014299915001582"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.02.039","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.02.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}