{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:37:12Z","timestamp":1761964632274,"version":"3.40.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.ejphar.2015.02.049","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T13:12:13Z","timestamp":1426079533000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats"],"prefix":"10.1016","volume":"755","author":[{"given":"Yoshiyuki","family":"Kamiide","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-8873","authenticated-orcid":false,"given":"Norio","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Yada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.02.049_bib1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1183\/09031936.03.00405703","article-title":"Systemic effects of chronic obstructive pulmonary disease","volume":"21","author":"Agusti","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2015.02.049_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1164\/rccm.2108013","article-title":"Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease","volume":"166","author":"Agusti","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib3","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jcem.86.10.7885","article-title":"Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans","volume":"86","author":"Ariyasu","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2015.02.049_bib4","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0140-6736(03)14416-9","article-title":"Chronic obstructive pulmonary disease","volume":"362","author":"Calverley","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2015.02.049_bib5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa021322","article-title":"The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease","volume":"350","author":"Celli","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0736-4679(99)00135-3","article-title":"The C-reactive protein","volume":"17","author":"Clyne","year":"1999","journal-title":"J. Emerg. Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1164\/rccm.200405-651OC","article-title":"Early emphysema in patients with anorexia nervosa","volume":"170","author":"Coxson","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib8","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1152\/japplphysiol.00091.2004","article-title":"Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling","volume":"97","author":"Dias","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2015.02.049_bib9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1378\/chest.127.2.558","article-title":"The interactions between cigarette smoking and reduced lung function on systemic inflammation","volume":"127","author":"Gan","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2015.02.049_bib10","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1210\/jcem.87.6.8739","article-title":"The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans","volume":"87","author":"Gnanapavan","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2015.02.049_bib11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1165\/rcmb.2008-0312OC","article-title":"Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure","volume":"40","author":"Gosker","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2015.02.049_bib12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/hc2901.093111","article-title":"Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure","volume":"104","author":"Goso","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2015.02.049_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0006-291X(02)03028-0","article-title":"Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells","volume":"301","author":"Hanada","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2015.02.049_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1164\/ajrccm.164.4.2007085","article-title":"Marked sympathetic activation in patients with chronic respiratory failure","volume":"164","author":"Heindl","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2011.09.183","article-title":"Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation","volume":"672","author":"Imazu","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.02.049_bib16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1164\/rccm.200310-1404OC","article-title":"Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease","volume":"170","author":"Itoh","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2015.02.049_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: structure and function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2015.02.049_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/bip.20342","article-title":"Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment","volume":"79","author":"Makino","year":"2005","journal-title":"Biopolymers"},{"key":"10.1016\/j.ejphar.2015.02.049_bib20","doi-asserted-by":"crossref","first-page":"L896","DOI":"10.1152\/ajplung.00333.2003","article-title":"Calorie-related rapid onset of alveolar loss, regeneration, and changes in mouse lung gene expression","volume":"286","author":"Massaro","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2015.02.049_bib21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.TP.0000132326.08628.74","article-title":"Lung epithelial cells and type II pneumocytes of donor origin after allogeneic hematopoietic stem cell transplantation","volume":"78","author":"Mattsson","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.ejphar.2015.02.049_bib22","first-page":"233","article-title":"A method for the routine assessment of fore- and hindlimb grip strength of rats and mice","volume":"1","author":"Meyer","year":"1979","journal-title":"Neurobehav. Toxicol."},{"key":"10.1016\/j.ejphar.2015.02.049_bib23","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1161\/01.CIR.0000149746.62908.BB","article-title":"Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure","volume":"110","author":"Nagaya","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2015.02.049_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/thx.2008.097543","article-title":"Body mass index in male patients with COPD: correlation with low attenuation areas on CT","volume":"64","author":"Ogawa","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2015.02.049_bib25","first-page":"3909","article-title":"Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates","volume":"81","author":"Ostlund","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2015.02.049_bib26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1183\/09031936.00109607","article-title":"Slow breathing reduces sympathoexcitation in COPD","volume":"32","author":"Raupach","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2015.02.049_bib27","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1164\/ajrccm.157.6.9705017","article-title":"Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease","volume":"157","author":"Schols","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib28","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1210\/en.2008-0472","article-title":"Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality","volume":"149","author":"Schwenke","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2015.02.049_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.regpep.2012.06.003","article-title":"Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice","volume":"178","author":"Sugiyama","year":"2012","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2015.02.049_bib30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jcp.21955","article-title":"TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure","volume":"222","author":"Tang","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2015.02.049_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2131\/jts.37.131","article-title":"Changes of ghrelin and leptin levels in plasma by cigarette smoke in rats","volume":"37","author":"Tomoda","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2015.02.049_bib32","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2015.02.049_bib33","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1055\/s-0029-1233462","article-title":"Expression of ghrelin and its receptor in human tissues","volume":"41","author":"Ueberberg","year":"2009","journal-title":"Horm. Metab. Res.=Hormon- und Stoffwechselforschung=Hormones et metabolisme"},{"key":"10.1016\/j.ejphar.2015.02.049_bib34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejim.2013.02.012","article-title":"Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight Chronic Obstructive Pulmonary Disease patients","volume":"25","author":"Uzum","year":"2014","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.02.049_bib36","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1183\/09031936.00074807","article-title":"Possible mechanisms underlying the development of cachexia in COPD","volume":"31","author":"Wagner","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2015.02.049_bib37","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1136\/thorax.57.12.1067","article-title":"Chronic obstructive pulmonary disease 5: systemic effects of COPD","volume":"57","author":"Wouters","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2015.02.049_bib38","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1152\/ajplung.90200.2008","article-title":"Animal models of chronic obstructive pulmonary disease","volume":"295","author":"Wright","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915001727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915001727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T10:21:51Z","timestamp":1537784511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915001727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":38,"alternative-id":["S0014299915001727"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.02.049","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.02.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}