{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:03:18Z","timestamp":1760295798737},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.ejphar.2015.04.025","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T08:20:37Z","timestamp":1430554837000},"page":"28-35","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats"],"prefix":"10.1016","volume":"761","author":[{"given":"Daniela","family":"Impellizzeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akbar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bruschetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Di Paola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalia","family":"Crupi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Paterniti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.04.025_bib1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.bbi.2012.07.021","article-title":"Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice","volume":"26","author":"Ahmad","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2015.04.025_bib2","doi-asserted-by":"crossref","first-page":"C145","DOI":"10.1007\/BF01972748","article-title":"A proposed autacoid mechanism controlling mastocyte behaviour","volume":"39","author":"Aloe","year":"1993","journal-title":"Agents Actions"},{"key":"10.1016\/j.ejphar.2015.04.025_bib3","first-page":"897","article-title":"Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis","volume":"39","author":"Behar-Cohen","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2015.04.025_bib4","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1167\/iovs.02-0559","article-title":"Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats","volume":"44","author":"Bucolo","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2015.04.025_bib5","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbrc.2005.03.095","article-title":"Finding of endocannabinoids in human eye tissues: implications for glaucoma","volume":"330","author":"Chen","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2015.04.025_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/jop.2000.16.407","article-title":"Inhibition of interleukin-1-induced uveitis and corneal fibroblast proliferation by interleukin-1 blockers","volume":"16","author":"Chiou","year":"2000","journal-title":"Ocular Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2015.04.025_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2009.04.022","article-title":"Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia","volume":"613","author":"D\u05f3Agostino","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/SHK.0b013e318267bbb9","article-title":"Palmitoylethanolamide reduces early renal dysfunction and injury caused by experimental ischemia and reperfusion in mice","volume":"38","author":"Di Paola","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2015.04.025_bib9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1189\/jlb.0911485","article-title":"Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice","volume":"91","author":"Di Paola","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1871527311312010010","article-title":"Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries","volume":"12","author":"Esposito","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ejphar.2015.04.025_bib11","doi-asserted-by":"crossref","first-page":"e41880","DOI":"10.1371\/journal.pone.0041880","article-title":"Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson\u05f3s disease","volume":"7","author":"Esposito","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2015.04.025_bib12","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bbi.2011.02.006","article-title":"Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury","volume":"25","author":"Esposito","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2015.04.025_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0304-3959(01)00419-5","article-title":"Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors","volume":"97","author":"Farquhar-Smith","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2015.04.025_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/jpet.108.136903","article-title":"Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury","volume":"326","author":"Genovese","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.04.025_bib15","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.4049\/jimmunol.154.12.6518","article-title":"Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase","volume":"154","author":"Goureau","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/oby.2008.591","article-title":"Anti-inflammatory effect of palmitoylethanolamide on human adipocytes","volume":"17","author":"Hoareau","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.ejphar.2015.04.025_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cyto.2006.06.005","article-title":"Effect of PEA on LPS inflammatory action in human adipocytes","volume":"34","author":"Hoareau","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.ejphar.2015.04.025_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm1709","article-title":"Oxidative damage-induced inflammation initiates age-related macular degeneration","volume":"14","author":"Hollyfield","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2015.04.025_bib19","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1167\/iovs.05-1429","article-title":"Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats","volume":"47","author":"Jin","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2015.04.025_bib20","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1167\/iovs.09-4873","article-title":"Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone","volume":"51","author":"Kalariya","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2015.04.025_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.07.008","article-title":"Regulation of autoimmune inflammation by pro-inflammatory cytokines","volume":"120","author":"Kim","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ejphar.2015.04.025_bib22","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1189\/jlb.0805453","article-title":"Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate","volume":"79","author":"Kitamei","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib23","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1167\/iovs.08-2666","article-title":"Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation","volume":"50","author":"Kubota","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2015.04.025_bib24","first-page":"2022","article-title":"The effects of intraocular injection of interleukin-13 on endotoxin-induced uveitis in rats","volume":"42","author":"Lemaitre","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2015.04.025_bib25","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/bjp.2008.315","article-title":"Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats","volume":"155","author":"Mangano","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.phrs.2013.07.007","article-title":"N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress","volume":"76","author":"Mattace Raso","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejphar.2015.04.025_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1124\/mol.108.046870","article-title":"Molecular mechanisms of topical anti-inflammatory effects of lipoxin A(4) in endotoxin-induced uveitis","volume":"74","author":"Medeiros","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tvjl.2005.10.003","article-title":"Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals","volume":"173","author":"Re","year":"2007","journal-title":"Vet. J."},{"key":"10.1016\/j.ejphar.2015.04.025_bib29","first-page":"223","article-title":"Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (review)","volume":"4","author":"Roebuck","year":"1999","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2015.04.025_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/1120672103013009-1008","article-title":"Malondialdehyde and antioxidant enzyme levels in the aqueous humor of rabbits in endotoxin-induced uveitis","volume":"13","author":"Satici","year":"2003","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib31","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1182\/blood.V83.9.2669.2669","article-title":"Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation","volume":"83","author":"Sellak","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2015.04.025_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1046\/j.1440-1711.1998.00783.x","article-title":"Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis","volume":"76","author":"Smith","year":"1998","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.exer.2005.06.023","article-title":"Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway","volume":"82","author":"Suzuki","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2015.04.025_bib34","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0891-5849(96)00170-0","article-title":"DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite","volume":"21","author":"Szabo","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2015.04.025_bib35","first-page":"717851","article-title":"Anti-inflammatory effects of adrenomedullin on acute lung injury induced by Carrageenan in mice","author":"Talero","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2015.04.025_bib36","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S1567-5769(02)00058-9","article-title":"The role of NF-kappaB in the regulation of cell stress responses","volume":"2","author":"Wang","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2015.04.025_bib37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0014-4835(05)80001-6","article-title":"Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis","volume":"60","author":"Whitcup","year":"1995","journal-title":"Exp. Eye Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915003696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915003696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T20:56:03Z","timestamp":1691614563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915003696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":37,"alternative-id":["S0014299915003696"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.04.025","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}