{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:43:52Z","timestamp":1788407032228,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ejphar.2015.05.050","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T21:13:38Z","timestamp":1432847618000},"page":"202-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Small molecule TBTC as a new selective retinoid X receptor \u03b1 agonist improves behavioral deficit in Alzheimer's disease model mice"],"prefix":"10.1016","volume":"762","author":[{"given":"Yanyan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7355","key":"10.1016\/j.ejphar.2015.05.050_bib1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/475S2a","article-title":"Dementia: a problem for our age","volume":"475","author":"Abbott","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2015.05.050_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12031-012-9866-6","article-title":"Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood\u2013brain barrier","volume":"49","author":"Bachmeier","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/13543784.15.3.243","article-title":"Recent findings concerning thiazolidinediones in the treatment of diabetes","volume":"15","author":"Boden","year":"2006","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.ejphar.2015.05.050_bib4","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","article-title":"Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum","volume":"65","author":"Campion","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejphar.2015.05.050_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jaad.2005.08.041","article-title":"A comparative study of two Congo red stains for the detection of primary cutaneous amyloidosis","volume":"55","author":"Cheung","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejphar.2015.05.050_bib6","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1523\/JNEUROSCI.23-26-08844.2003","article-title":"In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life","volume":"23","author":"Cirrito","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib7","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1217697","article-title":"ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models","volume":"335","author":"Cramer","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.05.050_bib8","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1039\/C3OB42478B","article-title":"Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity","volume":"12","author":"Dang","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib9","first-page":"297","article-title":"Small-molecule inhibitors and activators of calcium-activated chloride channels identified by high-throughput screening","author":"De la Fuente","year":"2007","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ejphar.2015.05.050_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbr.2007.12.024","article-title":"Age-dependent and -independent behavioral deficits in Tg2576 mice","volume":"189","author":"Deacon","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2015.05.050_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal","volume":"45","author":"Dietschy","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2015.05.050_bib12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<248::AID-GPS770>3.0.CO;2-0","article-title":"Determinants of carer stress in Alzheimer's disease","volume":"13","author":"Donaldson","year":"1998","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.05.050_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1745-7599.2008.00342.x","article-title":"Caregiver burden among dementia patient caregivers: a review of the literature","volume":"20","author":"Etters","year":"2008","journal-title":"J. Am. Acad. Nurse Pract."},{"key":"10.1016\/j.ejphar.2015.05.050_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12424","article-title":"Alzheimer's disease research and development: a call for a new research roadmap","volume":"1313","author":"Feldman","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2009.07.066","article-title":"Age-related cognitive decline and nesting behavior in an APPswe\/PS1 bigenic model of Alzheimer's disease","volume":"1292","author":"Filali","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2015.05.050_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1601-183X.2008.00453.x","article-title":"Cognitive and non-cognitive behaviors in an APPswe\/PS1 bigenic model of Alzheimer's disease","volume":"8","author":"Filali","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.ejphar.2015.05.050_bib17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1212\/WNL.0b013e318211c352","article-title":"Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging","volume":"76","author":"Gupta","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2015.05.050_bib18","unstructured":"Haberman, A.B., 2006. Safety Issues Hamper Dual PPAR Agonists Is Partial Antagonism the Solution?"},{"key":"10.1016\/j.ejphar.2015.05.050_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bpc.2008.12.001","article-title":"Equilibrium unfolding of the retinoid X receptor ligand binding domain and characterization of an unfolding intermediate","volume":"141","author":"Harder","year":"2009","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuti","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.05.050_bib21","doi-asserted-by":"crossref","first-page":"41197","DOI":"10.1074\/jbc.M407962200","article-title":"Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain","volume":"279","author":"Hirsch-Reinshagen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer's disea","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2015.05.050_bib23","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1074\/jbc.M607831200","article-title":"Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation","volume":"282","author":"Kim","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib24","doi-asserted-by":"crossref","first-page":"43224","DOI":"10.1074\/jbc.M504513200","article-title":"Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice","volume":"280","author":"Koldamova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib25","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1074\/jbc.M411420200","article-title":"The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease","volume":"280","author":"Koldamova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.molmed.2010.07.008","article-title":"APOE and cholesterol homeostasis in Alzheimer\u2019s disease","volume":"16","author":"Leduc","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2015.05.050_bib27","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1074\/jbc.M111.295451","article-title":"Apolipoprotein E promotes beta-amyloid trafficking and degradation by modulating microglial cholesterol levels","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib28","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1074\/jbc.M111.295451","article-title":"Apolipoprotein E promotes-amyloid trafficking and degradation by modulating microglial cholesterol levels","volume":"287","author":"Lee","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1021\/mp700121u","article-title":"PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks","volume":"5","author":"Lee","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.05.050_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1471-4159.2004.02183.x","article-title":"A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes","volume":"88","author":"Liang","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.05.050_bib32","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1517\/14728222.2011.594043","article-title":"Nuclear receptors as therapeutic targets for Alzheimer's disea","volume":"15","author":"Mandrekar-Colucci","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2015.05.050_bib33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12035-012-8337-y","article-title":"Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis","volume":"47","author":"Maulik","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2015.05.050_bib34","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS beta-amyloid in Alzheimer's disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.05.050_bib35","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s10072-013-1424-7","article-title":"Non-cognitive symptoms and related conditions in the Alzheimer's disease: a literature review","volume":"34","author":"Raudino","year":"2013","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","article-title":"Impaired spatial learning in the APP(Swe)+PSEN1 Delta E9 bigenic mouse model of Alzheimer's disease","volume":"6","author":"Reiserer","year":"2007","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.ejphar.2015.05.050_bib37","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.neurobiolaging.2009.10.009","article-title":"Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease","volume":"32","author":"Sato","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2015.05.050_bib38","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1248\/cpb.49.1299","article-title":"Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods","volume":"49","author":"Shen","year":"2001","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2015.05.050_bib39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12640-011-9272-9","article-title":"Alzheimer's disease pathologic cascades: who comes first, what drives what","volume":"22","author":"Swerdlow","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejphar.2015.05.050_bib40","first-page":"605","article-title":"Clearance of Alzheimer's Abeta peptide: the many roads to perdition","volume":"43","author":"Tanzi","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2015.05.050_bib41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jalz.2013.02.003","article-title":"Alzheimer's disease facts and figures","volume":"9","author":"Thies","year":"2013","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ejphar.2015.05.050_bib42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2013.03.021","article-title":"Impairment of nesting behaviour in 3xTg-AD mice","volume":"247","author":"Torres-Lista","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2015.05.050_bib43","first-page":"671","article-title":"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease","volume":"118","author":"Wahrle","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2015.05.050_bib44","doi-asserted-by":"crossref","first-page":"40987","DOI":"10.1074\/jbc.M407963200","article-title":"ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE","volume":"279","author":"Wahrle","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainresbull.2013.11.004","article-title":"Dynamic changes of Apo A1 mediated by LXR\/RXR\/ABCA1 pathway in brains of the aging rats with cerebral hypoperfusion","volume":"100","author":"Wang","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2015.05.050_bib46","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.drudis.2006.08.004","article-title":"Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives","volume":"11","author":"Wang","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2015.05.050_bib47","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbr.2010.08.033","article-title":"Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice","volume":"216","author":"Wesson","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2015.05.050_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/alzrt187","article-title":"Evidence for impaired amyloid beta clearance in Alzheimer\u2019s disease","volume":"5","author":"Wildsmith","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.ejphar.2015.05.050_bib49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/01677063.2011.620191","article-title":"Genes involved in cerebrospinal fluid production as candidate genes for late-onset Alzheimer's disease: a hypothesis","volume":"25","author":"Wostyn","year":"2011","journal-title":"J. Neurogenet."},{"key":"10.1016\/j.ejphar.2015.05.050_bib50","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2007.10.005","article-title":"Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and a beta production","volume":"29","author":"Xiong","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2015.05.050_bib51","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1523\/JNEUROSCI.5476-05.2006","article-title":"Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus","volume":"26","author":"Xu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib52","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.steroids.2013.04.018","article-title":"Identification of 15d-PGJ(2) as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation","volume":"78","author":"Xu","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.ejphar.2015.05.050_bib53","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1517\/13543776.2014.880692","article-title":"Retinoid X receptor ligands: a patent review (2007\u20132013)","volume":"24","author":"Yamada","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejphar.2015.05.050_bib54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-neuro-071013-014300","article-title":"Apolipoprotein e in Alzheimer's disease: an update","volume":"37","author":"Yu","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib55","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1074\/jbc.M110.166215","article-title":"Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib56","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1471-4159.2010.06751.x","article-title":"2,2\u2019,4\u2019-Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice","volume":"114","author":"Zhu","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2015.05.050_bib57","doi-asserted-by":"crossref","first-page":"13138","DOI":"10.1523\/JNEUROSCI.4790-12.2013","article-title":"Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both beta-amyloid production and clearance","volume":"33","author":"Zhu","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2015.05.050_bib58","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.prostaglandins.2013.09.002","article-title":"Regulation of prostaglandin F-2 alpha, against beta amyloid clearance and its inflammation induction through LXR\/RXR heterodimer antagonism in microglia","volume":"106","author":"Zhuang","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915300509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915300509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T15:19:15Z","timestamp":1566746355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915300509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":58,"alternative-id":["S0014299915300509"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.05.050","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small molecule TBTC as a new selective retinoid X receptor \u03b1 agonist improves behavioral deficit in Alzheimer's disease model mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.05.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}