{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:05:31Z","timestamp":1763017531271,"version":"3.41.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research at Musashino University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ejphar.2015.06.004","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T12:44:07Z","timestamp":1433594647000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: Comparison to procaine and bupropion"],"prefix":"10.1016","volume":"762","author":[{"given":"Akihiro","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Chazono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Iwajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.06.004_bib1","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1021\/bi802206k","article-title":"Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states","volume":"48","author":"Arias","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2015.06.004_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(25)28585-8","article-title":"Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs","volume":"174","author":"Boyes","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0022-3565(25)32266-4","article-title":"Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo","volume":"215","author":"Cooper","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1476-5381.1994.tb14789.x","article-title":"Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells","volume":"111","author":"Cuevas","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0976-500X.81901","article-title":"Adverse drug reaction profile of oseltamivir in children","volume":"2","author":"Dalvi","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.ejphar.2015.06.004_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-3565(24)37928-5","article-title":"Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine","volume":"288","author":"Fryer","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib7","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0022-3565(24)29227-2","article-title":"Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes","volume":"299","author":"Gentry","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-3565(25)10597-1","article-title":"The effect of cocaine and other local anesthetics on central dopaminergic neurotransmission","volume":"274","author":"Graham","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/bph.12102","article-title":"Inhibition of MAO-A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir","volume":"169","author":"Hiasa","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib10","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1128\/AAC.01541-08","article-title":"Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system","volume":"53","author":"Hoffmann","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejphar.2015.06.004_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2009.11.020","article-title":"In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu) and active metabolite","volume":"628","author":"Lindemann","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1213\/00000539-197809000-00014","article-title":"Interaction of muscle relaxants and local anesthetics at the neuromuscular junction","volume":"57","author":"Matsuo","year":"1978","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2015.06.004_bib13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2741\/3677","article-title":"Central neural pathways for thermoregulation","volume":"16","author":"Morrison","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejphar.2015.06.004_bib14","first-page":"e360","article-title":"Human nicotinic acetylcholine receptor is a potential pharmacological target of oseltamivir","volume":"1","author":"Muraki","year":"2014","journal-title":"Recept. Clin. Investig."},{"key":"10.1016\/j.ejphar.2015.06.004_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/bcpt.12290","article-title":"Oseltamivir blocks human neuronal nicotinic acetylcholine receptor-mediated currents","volume":"116","author":"Muraki","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.1978.sp012267","article-title":"Local anaesthetics transiently block currents through single acetylcholine-receptor channels","volume":"277","author":"Neher","year":"1978","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1248\/bpb.31.638","article-title":"Oseltamivir, an anti-influenza virus drug, produces hypothermia in mice","volume":"31","author":"Ono","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2015.06.004_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/bcpt.12058","article-title":"Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice","volume":"113","author":"Ono","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib19","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1021\/bi300101r","article-title":"Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72","volume":"51","author":"Pandhare","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2015.06.004_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1113\/jphysiol.1967.sp008237","article-title":"The margin of safety of neuromuscular transmission","volume":"191","author":"Paton","year":"1967","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2007.01.006","article-title":"Menthol and nicotine oppositely modulate body temperature in the rat","volume":"559","author":"Ruskin","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s002109900184","article-title":"Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics","volume":"361","author":"Sato","year":"2000","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.nmd.2004.01.005","article-title":"Competitive and open channel block of recombinant nAChR channels by different antibiotics","volume":"14","author":"Schlesinger","year":"2004","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.ejphar.2015.06.004_bib24","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1124\/jpet.106.111807","article-title":"Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel","volume":"319","author":"Shi","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0022-3565(24)38905-0","article-title":"Bupropion is a nicotinic antagonist","volume":"295","author":"Slemmer","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.004_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2009.12.028","article-title":"The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants","volume":"630","author":"Wang","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1254\/jjp.32.213","article-title":"Effects of local anesthetics on monoamine oxidase, and their membrane effects","volume":"32","author":"Yasuhara","year":"1982","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2008.04.011","article-title":"Oseltamivir (Tamiflu) increases dopamine levels in the rat medial prefrontal cortex","volume":"438","author":"Yoshino","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2015.06.004_bib29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF02801980","article-title":"Effects of bupropion on core body temperature of mice","volume":"106","author":"Zarrindast","year":"1992","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2015.06.004_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/026988119500900104","article-title":"Nicotine-induced hypothermia through an indirect dopaminergic mechanism","volume":"9","author":"Zarrindast","year":"1995","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.06.004_bib31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0091-3057(00)00457-3","article-title":"The possible cross-tolerance between morphine- and nicotine-induced hypothermia in mice","volume":"68","author":"Zarrindast","year":"2001","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915300674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915300674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:48:02Z","timestamp":1748432882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915300674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":31,"alternative-id":["S0014299915300674"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.06.004","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: Comparison to procaine and bupropion","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}