{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T20:10:01Z","timestamp":1748463001712,"version":"3.41.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ejphar.2015.06.016","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T04:03:34Z","timestamp":1434773014000},"page":"372-381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Contrasting cardiovascular properties of the \u00b5-opioid agonists morphine and methadone in the rat"],"prefix":"10.1016","volume":"762","author":[{"given":"Kenneth H.","family":"Tung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Angus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.06.016_bib1","doi-asserted-by":"crossref","first-page":"52A","DOI":"10.1016\/0002-9149(83)90177-7","article-title":"Responses of dog large coronary arteries to constrictor and dilator substances: implications for the cause and treatment of variant angina pectoris","volume":"52","author":"Angus","year":"1983","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2015.06.016_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0160-5402(81)90084-X","article-title":"Refractory period field stimulation of right atria: a method for studying presynaptic receptors in cardiac autonomic transmission","volume":"6","author":"Angus","year":"1981","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.ejphar.2015.06.016_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1056-8719(00)00121-0","article-title":"Techniques to study the pharmacodynamics of isolated large and small blood vessels","volume":"44","author":"Angus","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejphar.2015.06.016_bib4","first-page":"494","article-title":"Action of methadone on blood pressure regulating mechanisms","volume":"82","author":"Atanackovic","year":"1950","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib5","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/00001756-199510010-00007","article-title":"Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats","volume":"6","author":"Bian","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2015.06.016_bib6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1213\/01.ANE.0000097168.32472.0D","article-title":"Opioid-induced mast cell activation and vascular responses is not mediated by m-opioid receptors: an in vivo microdialysis study in human skin","volume":"98","author":"Blunk","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2015.06.016_bib7","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1213\/01.ANE.0000114085.20751.20","article-title":"Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate","volume":"98","author":"Bowdle","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2015.06.016_bib8","first-page":"451","article-title":"Elevated plasma histamine after heroin and morphine","volume":"83","author":"Brashear","year":"1974","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2015.06.016_bib9","first-page":"483","article-title":"The effects of narcotics and antagonists upon respiration and circulation in man. A review","volume":"1","author":"Eckenhoff","year":"1960","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0022-3565(25)28737-7","article-title":"Selective release of histamine from rat mast cells by several drugs","volume":"175","author":"Ellis","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"year":"2006","series-title":"S7B The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT interval prolongation) by Human Pharmaceuticals","author":"EMEA","key":"10.1016\/j.ejphar.2015.06.016_bib11"},{"key":"10.1016\/j.ejphar.2015.06.016_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.0954-6820.1920.tb18266.x","article-title":"Die systolendauer im elektrokardiogramm bei normalen menschen und bei herzkranken","volume":"57","author":"Fridericia","year":"1920","journal-title":"Acta Med. Scand."},{"key":"10.1016\/j.ejphar.2015.06.016_bib13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/BF01967614","article-title":"Histamine release from isolated rat mast cells: effect of morphine and related drugs and their interaction with compound 48\/80","volume":"11","author":"Grosman","year":"1981","journal-title":"Agents Actions"},{"key":"10.1016\/j.ejphar.2015.06.016_bib14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1124\/jpet.102.038240","article-title":"Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents","volume":"303","author":"Katchman","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0022-3565(25)30999-7","article-title":"Calcium antagonist activity of methadone, l-acetylmethadol and l-pentazocine in the rat aortic strip","volume":"202","author":"Lee","year":"1977","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/cvr\/28.3.303","article-title":"Repeated measurements and multiple comparisons in cardiovascular research","volume":"28","author":"Ludbrook","year":"1994","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2015.06.016_bib17","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.RES.39.4.566","article-title":"Inhibition of adrenergic neurotransmission in canine vascular smooth muscle by histamine: mediation by H2-receptors","volume":"39","author":"McGrath","year":"1976","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.06.016_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00000542-198310000-00011","article-title":"Histamine release by narcotics and muscle relaxants in humans","volume":"59","author":"Moss","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2015.06.016_bib19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/00005344-198705000-00012","article-title":"Plasma histamine and catecholamine levels during hypotension induced by morphine and compound 48\/80","volume":"9","author":"Muldoon","year":"1987","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.016_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.06.016_bib21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/cpt1973143338","article-title":"Methadone binding to human plasma proteins","volume":"14","author":"Olsen","year":"1973","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib22","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0028-3908(92)90041-M","article-title":"Evidence for differential opioid m 1- and m 2-receptor-mediated regulation of heart rate in the conscious rat","volume":"31","author":"Paakkari","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2015.06.016_bib23","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/0024-3205(86)90217-1","article-title":"Multiple m opiate receptors","volume":"38","author":"Pasternak","year":"1986","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2015.06.016_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00000542-198109000-00019","article-title":"The use of H1 and H2 histamine antagonists with morphine anesthesia: a double-blind study","volume":"55","author":"Philbin","year":"1981","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2015.06.016_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00000542-198202000-00003","article-title":"Histamine release during morphine and fentanyl anesthesia","volume":"56","author":"Rosow","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2015.06.016_bib26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0196-9781(86)90110-5","article-title":"Naturally occurring opioid peptides modulate H+-production by isolated rat parietal cells","volume":"7","author":"Schepp","year":"1986","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2015.06.016_bib27","first-page":"296","article-title":"Effect of butorphanol and morphine on pulmonary mechanics, arterial blood pressure and venous plasma histamine in the anesthetized dog","volume":"233","author":"Schurig","year":"1978","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib28","doi-asserted-by":"crossref","first-page":"30290","DOI":"10.1074\/jbc.270.51.30290","article-title":"Presence of the m3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation","volume":"270","author":"Stefano","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.06.016_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0896-6273(93)90120-G","article-title":"Cloning and pharmacological characterization of a rat m opioid receptor","volume":"11","author":"Thompson","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2015.06.016_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0022-3565(25)26700-3","article-title":"Elevation of plasma histamine levels in the dog following administration of muscle relaxants, opiates and macromolecular polymers","volume":"143","author":"Thompson","year":"1964","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.06.016_bib31","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0014-4827(59)90316-7","article-title":"Isolation of \u201cbiologically intact\u201d mast cells","volume":"18","author":"Uvnas","year":"1959","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2015.06.016_bib32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/0024-3205(75)90275-1","article-title":"Stereospecific increase by narcotic antagonists of evoked acetylcholine output in guinea-pig ileum","volume":"16","author":"Waterfield","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2015.06.016_bib33","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.78.10.6181","article-title":"Classification of multiple morphine and enkephalin binding sites in the central nervous system","volume":"78","author":"Wolozin","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2015.06.016_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/01.HYP.9.2.122","article-title":"Vascular amplifier properties in renovascular hypertension in conscious rabbits. Hindquarter responses to constrictor and dilator stimuli","volume":"9","author":"Wright","year":"1987","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2015.06.016_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00004872-200203000-00023","article-title":"Structural factors increase blood pressure through the interaction of resistance vessel geometry with neurohumoral and local factors: estimates in rabbits with renal cellophane-wrap hypertension with intact effectors and during neurohumoral blockade","volume":"20","author":"Wright","year":"2002","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2015.06.016_bib36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0006-3495(98)77782-3","article-title":"Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature","volume":"74","author":"Zhou","year":"1998","journal-title":"Biophys. J."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915300819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915300819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T19:30:14Z","timestamp":1748460614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915300819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":36,"alternative-id":["S0014299915300819"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.06.016","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contrasting cardiovascular properties of the \u00b5-opioid agonists morphine and methadone in the rat","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}