{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:48:13Z","timestamp":1791157693240,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81441009"],"award-info":[{"award-number":["81441009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejphar.2015.06.044","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T02:55:07Z","timestamp":1435719307000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Signal pathways involved in the biological effects of sulfur dioxide"],"prefix":"10.1016","volume":"764","author":[{"given":"Xin-Bao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Bao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.06.044_bib1","first-page":"1219","article-title":"Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury","volume":"27","author":"Chen","year":"2012","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/labinvest.2014.147","article-title":"Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats","volume":"95","author":"Chen","year":"2015","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ejphar.2015.06.044_bib3","first-page":"1901","article-title":"Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system","volume":"124","author":"Chen","year":"2011","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ejphar.2015.06.044_bib4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1745-7254.2008.00845.x","article-title":"Endogenously generated sulfur dioxide and its vasorelaxant effect in rats","volume":"29","author":"Du","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2015.06.044_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neulet.2013.12.042","article-title":"Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats","volume":"563","author":"Han","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2015.06.044_bib6","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2741\/e282","article-title":"Role of sulfur-containing gaseous substances in the cardiovascular system","volume":"3","author":"Hart","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejphar.2015.06.044_bib7","doi-asserted-by":"crossref","first-page":"22190","DOI":"10.3390\/ijms141122190","article-title":"The ERK1\/2 signaling pathway is involved in sulfur dioxide preconditioning-induced protection against cardiac dysfunction in isolated perfused rat heart subjected to myocardial ischemia\/reperfusion","volume":"14","author":"Huang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2015.06.044_bib8","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.3390\/ijms140510465","article-title":"The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury","volume":"14","author":"Jin","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2015.06.044_bib9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.niox.2013.04.008","article-title":"Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I\/R) injury","volume":"32","author":"Jin","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2015.06.044_bib10","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1745-7254.2008.00864.x","article-title":"Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats","volume":"29","author":"Jin","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2015.06.044_bib11","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1681\/ASN.V115923","article-title":"Elevated levels of serum sulfite in patients with chronic renal failure","volume":"11","author":"Kajiyama","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/MCA.0000000000000187","article-title":"Antioxidants and coronary artery disease: from pathophysiology to preventive therapy","volume":"26","author":"Leopold","year":"2015","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ejphar.2015.06.044_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejphar.2010.07.034","article-title":"Sulfur dioxide upregulates the aortic nitric oxide pathway in rats","volume":"645","author":"Li","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.niox.2008.12.003","article-title":"The role of sulfur dioxide as an endogenous gaseous vasoactive factor in synergy with nitric oxide","volume":"20","author":"Li","year":"2009","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2015.06.044_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chemosphere.2014.04.065","article-title":"Effect of sulfur dioxide on inflammatory and immune regulation in asthmatic rats","volume":"112","author":"Li","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejphar.2015.06.044_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.atherosclerosis.2010.12.037","article-title":"Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats","volume":"215","author":"Li","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2015.06.044_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/labinvest.2010.156","article-title":"Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats","volume":"91","author":"Liang","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ejphar.2015.06.044_bib18","doi-asserted-by":"crossref","first-page":"e1251","DOI":"10.1038\/cddis.2014.229","article-title":"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk\/MAP kinase pathway mediated by cAMP\/PKA signaling","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2015.06.044_bib19","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2174\/1389557511009011039","article-title":"Sulfur dioxide: a novel gaseous signal in the regulation of cardiovascular functions","volume":"10","author":"Liu","year":"2010","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.06.044_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbrc.2011.10.012","article-title":"Endogenous generation of sulfur dioxide in rat tissues","volume":"415","author":"Luo","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2015.06.044_bib21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbrc.2013.03.014","article-title":"Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow","volume":"433","author":"Luo","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2015.06.044_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/08958370304476","article-title":"Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide is a systemic oxidative damage agent","volume":"15","author":"Meng","year":"2003","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.envres.2004.04.008","article-title":"Oxidation damage of sulfur dioxide on testicles of mice","volume":"96","author":"Meng","year":"2004","journal-title":"Environ. Res."},{"key":"10.1016\/j.ejphar.2015.06.044_bib24","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3109\/08958370902798463","article-title":"Vasodilator effect of gaseous sulfur dioxide and regulation of its level by Ach in rat vascular tissues","volume":"21","author":"Meng","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.abb.2007.08.028","article-title":"Vasodilatation of sulfur dioxide derivatives and signal transduction","volume":"467","author":"Meng","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2015.06.044_bib26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/08958370701515175","article-title":"The vasodilator effect and its mechanism of sulfur dioxide-derivatives on isolated aortic rings of rats","volume":"19","author":"Meng","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.shk.0000105501.75189.85","article-title":"Increased levels of serum sulfite in patients with acute pneumonia","volume":"21","author":"Mitsuhashi","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2015.06.044_bib28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.shk.0000183393.83272.de","article-title":"Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neutrophils","volume":"24","author":"Mitsuhashi","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2015.06.044_bib29","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0026-895X(25)15175-4","article-title":"Direct detection of the sulfur trioxide radical anion during the horseradish peroxidase-hydrogen peroxide oxidation of sulfite (aqueous sulfur dioxide)","volume":"22","author":"Mottley","year":"1982","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbamem.2005.09.020","article-title":"Study of the interaction of sulfur dioxide derivative with cardiac sodium channel","volume":"1718","author":"Nie","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2015.06.044_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.abb.2005.08.004","article-title":"Sulfur dioxide derivative modulation of potassium channels in rat ventricular myocytes","volume":"442","author":"Nie","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2015.06.044_bib32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3109\/08958370903341891","article-title":"Expression of oncogenes and tumor suppressor genes in lungs of rats exposed to sulfur dioxide and benzo(a)pyrene","volume":"22","author":"Qin","year":"2010","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib33","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/carcin\/11.9.1635","article-title":"Sulfite enhancement of diolepoxide mutagenicity: the role of altered glutathione metabolism","volume":"11","author":"Reed","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2015.06.044_bib34","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.ecoenv.2008.07.007","article-title":"SO2 inhalation induces protein oxidation, DNA-protein crosslinks and apoptosis in rat hippocampus","volume":"72","author":"Sang","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ejphar.2015.06.044_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-1110(77)90020-3","article-title":"Genetic effects of bisulfite (sulfur dioxide)","volume":"39","author":"Shapiro","year":"1977","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ejphar.2015.06.044_bib36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.nu.06.070186.001143","article-title":"Metabolism of sulfur-containing amino acids","volume":"6","author":"Stipanuk","year":"1986","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ejphar.2015.06.044_bib37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.nutr.24.012003.132418","article-title":"Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine","volume":"24","author":"Stipanuk","year":"2004","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ejphar.2015.06.044_bib38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/jn\/120.5.450","article-title":"Catabolism of cyst(e)ine by rat renal cortical tubules","volume":"120","author":"Stipanuk","year":"1990","journal-title":"J. Nutr."},{"key":"10.1016\/j.ejphar.2015.06.044_bib39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/labinvest.2009.102","article-title":"Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling","volume":"90","author":"Sun","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ejphar.2015.06.044_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.lfs.2013.12.027","article-title":"Sulfur dioxide, a double-faced molecule in mammals","volume":"98","author":"Wang","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2015.06.044_bib41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00395-011-0176-x","article-title":"Effect of sulfur dioxide preconditioning on rat myocardial ischemia\/reperfusion injury by inducing endoplasmic reticulum stress","volume":"106","author":"Wang","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib42","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1440-1681.2009.05249.x","article-title":"Significance of endogenous sulphur-containing gases in the cardiovascular system","volume":"37","author":"Wang","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2011.08.031","article-title":"The biological effect of endogenous sulfur dioxide in the cardiovascular system","volume":"670","author":"Wang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.33549\/physiolres.931456","article-title":"Sulfur dioxide relaxes rat aorta by endothelium-dependent and -independent mechanisms","volume":"58","author":"Wang","year":"2009","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2015.06.044_bib45","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.3760\/cma.j.issn.0366-6999.20133059","article-title":"Changes of sulfur dioxide, nuclear factor-kappaB, and interleukin-8 levels in pediatric acute lymphoblastic leukemia with bacterial inflammation","volume":"127","author":"Wu","year":"2014","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ejphar.2015.06.044_bib46","first-page":"384627","article-title":"Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: activation of eNOS via the PI3K\/Akt pathway","author":"Wu","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2008.11.030","article-title":"The vasodilator mechanism of sulfur dioxide on isolated aortic rings of rats: involvement of the K+ and Ca2+ channels","volume":"602","author":"Zhang","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejphar.2014.08.025","article-title":"Effects of gaseous sulfur dioxide and its derivatives on the expression of KATP, BKCa and l-Ca2+ channels in rat aortas in vitro","volume":"742","author":"Zhang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib49","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1440-1681.2011.05528.x","article-title":"Sulfur dioxide derivatives depress l-type calcium channel in rat cardiomyocytes","volume":"38","author":"Zhang","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2015.06.044_bib50","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/aps.2012.204","article-title":"The PI3K\/Akt pathway mediates the protection of SO2 preconditioning against myocardial ischemia\/reperfusion injury in rats","volume":"34","author":"Zhao","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2015.06.044_bib51","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","article-title":"H2S-induced vasorelaxation and underlying cellular and molecular mechanisms","volume":"283","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915301084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915301084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:22:40Z","timestamp":1757974960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915301084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":51,"alternative-id":["S0014299915301084"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.06.044","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signal pathways involved in the biological effects of sulfur dioxide","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.06.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}