{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:07:00Z","timestamp":1780614420998,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1508085MH179"],"award-info":[{"award-number":["1508085MH179"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102864"],"award-info":[{"award-number":["81102864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejphar.2015.07.040","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T20:57:41Z","timestamp":1437166661000},"page":"448-456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Renoprotective effects of berberine through regulation of the MMPs\/TIMPs system in streptozocin-induced diabetic nephropathy in rats"],"prefix":"10.1016","volume":"764","author":[{"given":"Wei-Jian","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ye","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.07.040_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000363300","article-title":"Recent advances in animal models of diabetic nephropathy","volume":"126","author":"Betz","year":"2014","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib2","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.2337\/db14-1001","article-title":"Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes","volume":"64","author":"Brown","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2015.07.040_bib3","doi-asserted-by":"crossref","first-page":"F905","DOI":"10.1152\/ajprenal.00421.2006","article-title":"Role of matrix metalloproteinases in renal pathophysiologies","volume":"292","author":"Catania","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2014.09.016","article-title":"Myocardial matrix metalloproteinase-2: inside out and upside down","volume":"77","author":"DeCoux","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib5","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.2337\/db13-0305","article-title":"Transforming growth factor-beta-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy","volume":"62","author":"Deshpande","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2015.07.040_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/15476286.2015.1017219","article-title":"Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of mir-99a approximately 125b cluster function by seed-targeting inhibitors in multiple myeloma cells","volume":"12","author":"Feng","year":"2015","journal-title":"RNA Biol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.ejphar.2015.07.040_bib8","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1093\/ndt\/gfl238","article-title":"An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy","volume":"21","author":"Han","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ejphar.2015.07.040_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrneph.2014.116","article-title":"Diabetic nephropathy\u2014emerging epigenetic mechanisms","volume":"10","author":"Kato","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib10","first-page":"L1006","article-title":"Matrix metalloproteinase-9 activates TGF-beta and stimulates fibroblast contraction of collagen gels","volume":"306","author":"Kobayashi","year":"2014","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/ki.2014.67","article-title":"Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation","volume":"86","author":"Li","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2015.07.040_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrneph.2013.272","article-title":"The gut-renal axis: do incretin-based agents confer renoprotection in diabetes?","volume":"10","author":"Muskiet","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2015.04.017","article-title":"Berberine as a promising anti-diabetic nephropathy drug: an analysis of its effects and mechanisms","volume":"760","author":"Ni","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/dmrr.2568","article-title":"Research progress in signalling pathway in diabetic nephropathy","volume":"31","author":"Ni","year":"2015","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.ejphar.2015.07.040_bib15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","volume":"75","author":"Raffetto","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib16","first-page":"444","article-title":"Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy","volume":"20","author":"Rysz","year":"2007","journal-title":"J. Nephrol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10157-012-0633-3","article-title":"Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of matrix metalloproteinases 2 and 1 in the glomeruli of human glomerular diseases: the results of studies using immunofluorescence, in situ hybridization, and immunoelectron microscopy","volume":"16","author":"Sekiuchi","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib18","first-page":"483","article-title":"Diabetic nephropathy: heparanase mediates renal injury","volume":"10","author":"Sidaway","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib19","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.ki.5002180","article-title":"Phenotypic transitions and fibrosis in diabetic nephropathy","volume":"71","author":"Simonson","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2015.07.040_bib20","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1097\/HJH.0b013e32834abceb","article-title":"Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation","volume":"29","author":"Solini","year":"2011","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2015.07.040_bib21","doi-asserted-by":"crossref","first-page":"F1351","DOI":"10.1152\/ajprenal.00037.2012","article-title":"Matrix metalloproteinases in kidney homeostasis and diseases","volume":"302","author":"Tan","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib22","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1007\/s11033-012-2468-0","article-title":"Berberine ameliorates renal injury by regulating G proteins-AC-cAMP signaling in diabetic rats with nephropathy","volume":"40","author":"Tang","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2015.07.040_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2013.81","article-title":"Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta1 signaling","volume":"84","author":"Ueno","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2015.07.040_bib24","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s11033-012-2321-5","article-title":"Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats","volume":"40","author":"Wang","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2015.07.040_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2013.07.019","article-title":"Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA\/ROCK signaling","volume":"381","author":"Xie","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2015.07.040_bib26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/10799893.2014.917324","article-title":"The renoprotective effects of berberine via the EP4-Galphas-cAMP signaling pathway in different stages of diabetes in rats","volume":"34","author":"Yang","year":"2014","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.ejphar.2015.07.040_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12013-014-0474-7","article-title":"Effect of cyclophosphamide on expression of MMP-9 and TGF-beta1 in renal tissue of rats with diabetes mellitus","volume":"72","author":"Zhang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2015.07.040_bib28","doi-asserted-by":"crossref","first-page":"e113398","DOI":"10.1371\/journal.pone.0113398","article-title":"Berberine improves kidney function in diabetic mice via AMPK activation","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915301680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915301680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:27:10Z","timestamp":1757975230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915301680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":28,"alternative-id":["S0014299915301680"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.07.040","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renoprotective effects of berberine through regulation of the MMPs\/TIMPs system in streptozocin-induced diabetic nephropathy in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.07.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}