{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:26:45Z","timestamp":1788384405266,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001332","name":"CSIR","doi-asserted-by":"publisher","award":["BSC-0205"],"award-info":[{"award-number":["BSC-0205"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"CSIR","doi-asserted-by":"publisher","award":["BSC-0302"],"award-info":[{"award-number":["BSC-0302"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejphar.2015.08.018","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T17:18:46Z","timestamp":1439831926000},"page":"75-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A novel stereo bioactive metabolite isolated from an endophytic fungus induces caspase dependent apoptosis and STAT-3 inhibition in human leukemia cells"],"prefix":"10.1016","volume":"765","author":[{"given":"Anup Singh","family":"Pathania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Guru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissar","family":"Ul Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Riyaz-Ul-Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh","family":"Abdullah Tasduq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayaz","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Bhushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.08.018_bib1","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/bcr1680","article-title":"Stat3 is tyrosine-phosphorylated through the interleukin-6\/glycoprotein 130\/Janus kinase pathway in breast cancer","volume":"9","author":"Berishaj","year":"2007","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ejphar.2015.08.018_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.niox.2005.09.009","article-title":"A novel lignan composition from Cedrus deodara induces apoptosis and early nitric oxide generation in human leukemia MOLT-4 and HL-60 cells","volume":"14","author":"Bhushan","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2015.08.018_bib3","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s10495-007-0105-5","article-title":"A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells","volume":"12","author":"Bhushan","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2015.08.018_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00253-012-4128-7","article-title":"Endophytic fungi: novel sources of anticancer lead molecules","volume":"95","author":"Chandra","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib5","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/sj.onc.1203479","article-title":"The role of STATs in myeloid differentiation and leukemia","volume":"19","author":"Coffer","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2015.08.018_bib6","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1182\/blood.V95.8.2577","article-title":"Induction of apoptosis by extracellular ubiquitinin human hematopoietic cells: Possible involvement of STAT-3 degradation by proteosome pathway in interleukin 6\u2011dependent hematopoietic cells","volume":"95","author":"Daino","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2015.08.018_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-4274(99)00252-0","article-title":"Activation of apoptosis pathways by anti-cancer treatment","volume":"112\/113","author":"Debatin","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2015.08.018_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ja.2008.16","article-title":"Microbial drug discovery: 80 years of progress","volume":"6","author":"Demain","year":"2009","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.ejphar.2015.08.018_bib9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/np058128n","article-title":"Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence","volume":"69","author":"Gunatilaka","year":"2006","journal-title":"J. Natural Prod."},{"key":"10.1016\/j.ejphar.2015.08.018_bib12","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.2174\/092986712800672111","article-title":"Compounds derived from endophytes: a review of photochemistry and pharmacology","volume":"19","author":"Gutierrez","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.08.018_bib13","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural products in drug discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2015.08.018_bib14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0955-0674(97)80079-8","article-title":"Roles of ubiquitin-mediated proteolysis in cell cycle control","volume":"9","author":"Hershko","year":"1997","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10495-013-0805-y","article-title":"Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells","volume":"18","author":"Kumar","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2015.08.018_bib16","doi-asserted-by":"crossref","first-page":"10151","DOI":"10.1073\/pnas.0604042103","article-title":"STAT-3: a multifaceted oncogene","volume":"103","author":"Levy","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2015.08.018_bib17","doi-asserted-by":"crossref","first-page":"574","DOI":"10.18632\/oncotarget.1911","article-title":"Antitumour and antimicrobial activities of endophytic streptomycetes from pharmaceutical plants in rainforest","volume":"47","author":"Li","year":"2008","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib18","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.18632\/oncotarget.1911","article-title":"Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells","volume":"5","author":"Licht","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2015.08.018_bib20","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1038\/sj.onc.1203486","article-title":"STAT signaling in the pathogenesis and treatment of leukemias","volume":"19","author":"Lin","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2015.08.018_bib21","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1158\/0008-5472.CAN-06-3497","article-title":"Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate","volume":"67","author":"Liu","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2015.08.018_bib22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)81589-5","article-title":"Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors","volume":"94","author":"Luo","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2015.08.018_bib23","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1007\/s10495-007-0129-x","article-title":"Reactive oxygen species generation and mitochondrial dysfunctionin the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin a with concomitant protection by N-acetyl cysteine","volume":"12","author":"Malik","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2015.08.018_bib24","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tibs.2005.09.005","article-title":"Mammalian cyclin dependent kinases","volume":"30","author":"Malumbres","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2015.08.018_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: a changing paradigm","volume":"9","author":"Malumbres","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2015.08.018_bib26","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1074\/jbc.M207637200","article-title":"Apoptosis in leukemia cell is accompanied by alterations in the level and localization of nucleolin","volume":"278","author":"Mi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.08.018_bib27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/bbrc.2001.4627","article-title":"Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1","volume":"282","author":"Nakayama","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2015.08.018_bib28","first-page":"1280","article-title":"Microbial antitumor drugs: natural products of microbial origin as anticancer agents","volume":"10","author":"Newman","year":"2009","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.ejphar.2015.08.018_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbrc.2010.02.163","article-title":"Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF)","volume":"21","author":"Norberg","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2015.08.018_bib31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1158\/1541-7786.MCR-06-0348","article-title":"Ursolic acid inhibits stat3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells","volume":"5","author":"Pathak","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ejphar.2015.08.018_bib32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fct.2013.08.037","article-title":"Disruption of the PI3K\/AKT\/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora","volume":"62","author":"Pathania","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejphar.2015.08.018_bib34","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/sj.cdd.4400889","article-title":"Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential","volume":"8","author":"Smaili","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2015.08.018_bib36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1039\/b100918o","article-title":"Endophytes: a rich source of functional metabolites","volume":"18","author":"Tan","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejphar.2015.08.018_bib37","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.1128\/JVI.79.16.10180-10189.2005","article-title":"Composition and assembly of STAT\u2011targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain","volume":"79","author":"Ulane","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib38","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1038\/onc.2012.347","article-title":"JAK\/STAT signaling in haematological malignancies","volume":"32","author":"Vainchenker","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2015.08.018_bib39","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1083\/jcb.139.5.1281","article-title":"Movement of Bax from the cytosol to mitochondria during apoptosis","volume":"139","author":"Wolter","year":"1997","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejphar.2015.08.018_bib40","doi-asserted-by":"crossref","first-page":"31199","DOI":"10.1074\/jbc.C000405200","article-title":"Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1","volume":"275","author":"Xeujun","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.08.018_bib41","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT-3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2015.08.018_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.phytochem.2013.06.021","article-title":"Bioactive metabolites from an endophytic cryptosporiopsis sp. inhabiting Clidemia hirta","volume":"95C","author":"Zilla","year":"2013","journal-title":"Phytochemistry"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915301928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915301928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T08:03:30Z","timestamp":1599465810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915301928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":38,"alternative-id":["S0014299915301928"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.018","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel stereo bioactive metabolite isolated from an endophytic fungus induces caspase dependent apoptosis and STAT-3 inhibition in human leukemia cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}