{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:52:47Z","timestamp":1789271567602,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Shanxi Province Colleges and Universities","award":["20131007"],"award-info":[{"award-number":["20131007"]}]},{"name":"Changzhi Medical College","award":["CX201409"],"award-info":[{"award-number":["CX201409"]}]},{"name":"College Students Innovation and Entrepreneurship Training Project of Shanxi Province","award":["2014308"],"award-info":[{"award-number":["2014308"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejphar.2015.08.040","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T21:20:55Z","timestamp":1440796855000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"C","title":["Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS\/TLR4\/NF-\u03baB signaling pathway in rats"],"prefix":"10.1016","volume":"765","author":[{"given":"Lina","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghui","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buwu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ejphar.2015.08.040_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.intimp.2014.02.006","article-title":"Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice","volume":"19","author":"Bai","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.ejphar.2015.08.040_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1172\/JCI200317464","article-title":"Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells","volume":"112","author":"Becker","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.ejphar.2015.08.040_bib6","doi-asserted-by":"crossref","first-page":"G571","DOI":"10.1152\/ajpgi.00537.2004","article-title":"Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells","volume":"289","author":"Brun","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"15","key":"10.1016\/j.ejphar.2015.08.040_bib7","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/jsfa.4521","article-title":"Hydrolysable tannins of tropical almond show antifibrotic effects in TGF-\u03b21-induced hepatic stellate cells","volume":"91","author":"Chuang","year":"2011","journal-title":"J. Sci. Food Agric."},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.ejphar.2015.08.040_bib9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1499-3872(12)60210-0","article-title":"Organ fibrosis inhibited by blocking transforming growth factor-\u03b2 signaling via peroxisome proliferator-activated receptor \u03b3 agonists","volume":"11","author":"Deng","year":"2012","journal-title":"Hepatobiliary Pancreat Dis. Int."},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/hep.21802","article-title":"NF-\u03baB and the hepatic inflammation-fibrosis-cancer axis","volume":"46","author":"Elsharkawy","year":"2007","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib11","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0168-8278(95)80204-5","article-title":"Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia","volume":"23","author":"Grinko","year":"1995","journal-title":"J. Hepatol."},{"issue":"16","key":"10.1016\/j.ejphar.2015.08.040_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.0105-2896.2006.00375.x","article-title":"Circuitry of nuclear factor \u03baB signaling","volume":"210","author":"Hoffmann","year":"2006","journal-title":"Immunol. Rev."},{"issue":"3","key":"10.1016\/j.ejphar.2015.08.040_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"Karin","year":"2002","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00109-008-0426-z","article-title":"Toll-like receptors, wound healing and carcinogenesis","volume":"87","author":"Kluwe","year":"2009","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2015.08.040_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2011.12.034","article-title":"Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells","volume":"509","author":"Lee","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.ejphar.2015.08.040_bib17","doi-asserted-by":"crossref","first-page":"e26500","DOI":"10.1371\/journal.pone.0026500","article-title":"Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells","volume":"6","author":"Longxi","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0168-8278(95)80424-2","article-title":"Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation","volume":"22","author":"Lin","year":"1995","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.ejphar.2015.08.040_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0016-5085(78)90848-X","article-title":"Modification of acute carbon tetrachloride injury by polymyxin b-an antiendotoxin","volume":"75","author":"Nolan","year":"1978","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ejphar.2015.08.040_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","article-title":"NF-\u03baB and cancer-identifying targets and mechanisms","volume":"18","author":"Naugler","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"3","key":"10.1016\/j.ejphar.2015.08.040_bib21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1055\/s-0030-1255353","article-title":"Toll-like receptor 4 and hepatic fibrogenesis","volume":"30","author":"Pradere","year":"2010","journal-title":"Semin. Liver Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2567.2004.01976.x","article-title":"Signal transduction by the lipopolysaccharide receptor Toll-like receptor-4","volume":"113","author":"Palsson-McDermott","year":"2004","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.ejphar.2015.08.040_bib23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","article-title":"Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells","volume":"37","author":"Paik","year":"2003","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.ejphar.2015.08.040_bib24","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1053\/jhep.2003.50180","article-title":"Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis","volume":"37","author":"Riordan","year":"2003","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib26","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1053\/j.gastro.2009.02.001","article-title":"Biological therapies for inflammatory bowel diseases","volume":"136","author":"Rutgeerts","year":"2009","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.ejphar.2015.08.040_bib27","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"issue":"6894","key":"10.1016\/j.ejphar.2015.08.040_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.ejphar.2015.08.040_bib29","doi-asserted-by":"crossref","first-page":"29433","DOI":"10.1074\/jbc.M803905200","article-title":"Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14\/TLR4\/MD2-dependent uptake of lipopolysaccharide by hepatocytes","volume":"283","author":"Scott","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.ejphar.2015.08.040_bib30","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/MEG.0b013e32834a75dc","article-title":"Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt","volume":"23","author":"Trebicka","year":"2011","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.ejphar.2015.08.040_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.vph.2004.11.001","article-title":"Apoptosis of human umbilical vein endothelial cells induced by artesunate","volume":"41","author":"Wu","year":"2004","journal-title":"Vasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.040_bib32","first-page":"916","article-title":"Effect of artesunate on endotoxin-induced uveitis in rats","volume":"52","author":"Wang","year":"2011","journal-title":"IOVS"},{"issue":"3","key":"10.1016\/j.ejphar.2015.08.040_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/hep.20632","article-title":"Bacterial translocation (BT) in cirrhosis","volume":"41","author":"Wiest","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2015.08.040_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2014.09.035","article-title":"Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases","volume":"744","author":"Xu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"26","key":"10.1016\/j.ejphar.2015.08.040_bib35","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.2174\/092986712803251575","article-title":"Immunomodulatory and anti-inflammatory properties of artesunate in experimental colitis","volume":"19","author":"Yang","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib36","first-page":"294","article-title":"Impact of artesunate on the expression and secretion of transforming growth factor-\u03b21 of primary rat hepatic stellate cells","volume":"20","author":"Yuan","year":"2012","journal-title":"Chin. J. Hepatol."},{"key":"10.1016\/j.ejphar.2015.08.040_bib37","first-page":"6","article-title":"Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene","volume":"19","author":"Yang","year":"2007","journal-title":"Comp. Hepatol."},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.040_bib38","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jhep.2011.11.013","article-title":"Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice","volume":"56","author":"Zhu","year":"2012","journal-title":"J. Hepatol."},{"issue":"25","key":"10.1016\/j.ejphar.2015.08.040_bib39","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.3748\/wjg.v13.i25.3500","article-title":"Multiple pathogenic factor-induced complications of liver cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia","volume":"13","author":"Zhang","year":"2007","journal-title":"World J. Gastroenterol."},{"issue":"47","key":"10.1016\/j.ejphar.2015.08.040_bib40","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.3748\/wjg.v13.i47.6385","article-title":"Intestinal endotoxemia plays a central role in development of hepatopulmonary syndrome in a cirrhotic rat model induced by multiple pathogenic factors","volume":"13","author":"Zhang","year":"2007","journal-title":"World J. Gastroenterol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T23:49:44Z","timestamp":1567122584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915302144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":40,"alternative-id":["S0014299915302144"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.040","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS\/TLR4\/NF-\u03baB signaling pathway in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}