{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:25:02Z","timestamp":1792301102587,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejphar.2015.08.041","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T17:57:46Z","timestamp":1440784666000},"page":"242-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma"],"prefix":"10.1016","volume":"765","author":[{"given":"Yasuo","family":"Yonetomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Sekioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Kadode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kitamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuto","family":"inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Nambu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Nakade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.08.041_bib1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/sj.bjp.0704180","article-title":"An alternative pathway for metabolism of leukotriene D4: effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea","volume":"133","author":"B\u00e4ck","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib2","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1038\/srep03274","article-title":"Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT2 and CysLT1 receptors","volume":"3","author":"Duah","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2015.08.041_bib3","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1046\/j.1365-2222.2003.01786.x","article-title":"Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis","volume":"33","author":"Figueroa","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2015.08.041_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jaci.2009.12.978","article-title":"Achieving asthma control in patients with moderate disease","volume":"125","author":"FitzGerald","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jaci.2005.03.014","article-title":"Expression of functional cysteinyl leukotriene receptors by human basophils","volume":"116","author":"Gauvreau","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib6","doi-asserted-by":"crossref","first-page":"30531","DOI":"10.1074\/jbc.M003490200","article-title":"Characterization of the human cysteinyl leukotriene 2 receptor","volume":"275","author":"Heise","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.08.041_bib7","author":"Harter","year":"2006","journal-title":"Isophthalic acid derivatives"},{"key":"10.1016\/j.ejphar.2015.08.041_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1398-9995.2006.00993.x","article-title":"Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics","volume":"61","author":"Hemelaers","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2015.08.041_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5483\/BMBRep.2008.41.2.139","article-title":"Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4","volume":"41","author":"Ito","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.ejphar.2015.08.041_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01861842","article-title":"Versuchsanordnung zu untersuchungen an der Bronchial-muskulatur","volume":"195","author":"Konzett","year":"1940","journal-title":"Arch. Exp. Pathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1164\/rccm.200509-1412OC","article-title":"Influence of leukotriene pathway polymorphisms on response to montelukast in asthma","volume":"173","author":"Lima","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2015.08.041_bib12","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/21658","article-title":"Characterization of the human cysteinyl leukotriene CysLT1 receptor","volume":"399","author":"Lynch","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2015.08.041_bib13","first-page":"449","article-title":"Slow-reacting substances of anaphylaxis, leukotrienes C4 and D4 increase the release of mucus from human airways in vitro","volume":"126","author":"Marom","year":"1982","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2015.08.041_bib14","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.jaci.2003.09.021","article-title":"Considering therapeutic options in the real world","volume":"112","author":"Martin","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1517\/14656566.2014.872241","article-title":"Leukotriene receptor antagonists pranlukast and montelukast for treating asthma","volume":"15","author":"Matsuse","year":"2014","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.ejphar.2015.08.041_bib16","doi-asserted-by":"crossref","first-page":"11589","DOI":"10.1073\/pnas.2034927100","article-title":"Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: functional distinction from CysLT1R","volume":"100","author":"Mellor","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2015.08.041_bib17","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1046\/j.1365-2222.2001.01184.x","article-title":"Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils","volume":"31","author":"Mita","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2015.08.041_bib18","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1111\/j.1365-2222.2010.03630.x","article-title":"Leukotriene modifiers for asthma treatment","volume":"40","author":"Montuschi","year":"2010","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2015.08.041_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1254\/jjp.60.217","article-title":"In vivo pharmacologic profile of ONO-1078: a potent, selective and orally active peptide leukotriene (LT) antagonist","volume":"60","author":"Nakagawa","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib20","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1016\/S0021-9258(19)70597-3","article-title":"Inhibition of leukotriene C and leukotriene D biosynthesis","volume":"255","author":"Orning","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.08.041_bib21","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJMra071371","article-title":"Leukotrienes","volume":"357","author":"Peters-Golden","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2015.08.041_bib22","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.6301011","article-title":"Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation","volume":"220","author":"Samuelsson","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.08.041_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.alit.2015.04.008","article-title":"Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction","author":"Sekioka","year":"2015","journal-title":"Allergol. Int."},{"key":"10.1016\/j.ejphar.2015.08.041_bib23","doi-asserted-by":"crossref","first-page":"922","DOI":"10.3109\/02770903.2013.823447","article-title":"A review on leukotrienes and their receptors with reference to asthma","volume":"50","author":"Singh","year":"2013","journal-title":"J. Asthma"},{"key":"10.1016\/j.ejphar.2015.08.041_bib24","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1161\/01.ATV.0000082689.46538.DF","article-title":"Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells","volume":"23","author":"Sj\u00f6str\u00f6m","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2015.08.041_bib25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejphar.2015.02.014","article-title":"Leukotriene C4 induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs","volume":"754","author":"Yonetomi","year":"2015","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T22:44:47Z","timestamp":1653086687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915302156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":26,"alternative-id":["S0014299915302156"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.041","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}