{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:11:32Z","timestamp":1787497892994,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejphar.2015.08.053","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T18:27:34Z","timestamp":1440872854000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors"],"prefix":"10.1016","volume":"765","author":[{"given":"Ana F.","family":"Almeida-Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata C.M.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor D.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele C.","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago R.L.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricio A.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.08.053_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0269881108098820","article-title":"A UK consensus on the administration of aripiprazole for the treatment of mania","volume":"23","author":"Aitchison","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2014.09.004","article-title":"The antipsychotic aripiprazole selectively prevents the stimulant and rewarding effects of morphine in mice","author":"Almeida-Santos","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1016\/j.ejphar.2015.08.053_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-2999(01)01029-9","article-title":"In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia","volume":"421","author":"Bardin","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40263-013-0128-0","article-title":"Drug repositioning: playing dirty to kill pain","volume":"28","author":"Bastos","year":"2014","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2015.08.053_bib6","first-page":"1346","article-title":"Aripiprazole, alcohol and substance abuse: a review","volume":"16","author":"Brunetti","year":"2012","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2015.08.053_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1124\/jpet.102.033175","article-title":"Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors","volume":"302","author":"Burris","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.08.053_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00213-009-1611-7","article-title":"Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder","volume":"206","author":"Chernoloz","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2015.08.053_bib9","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.neuroscience.2010.06.050","article-title":"The role of dopamine receptors in ventrolateral orbital cortex-evoked anti-nociception in a rat model of neuropathic pain","volume":"169","author":"Dang","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2015.08.053_bib10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0149-2918(04)90066-5","article-title":"Aripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability","volume":"26","author":"DeLeon","year":"2004","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejphar.2015.08.053_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-4886(83)90166-8","article-title":"Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests","volume":"81","author":"Dennis","year":"1983","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2015.08.053_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/2045125312451271","article-title":"Unexpected effect of aripiprazole on nociceptive pain","volume":"2","author":"Fei","year":"2012","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib14","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.biopsych.2006.04.010","article-title":"Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse","volume":"61","author":"Feltenstein","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.08.053_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0090-6980(79)90104-7","article-title":"II-Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists","volume":"18","author":"Ferreira","year":"1979","journal-title":"Prostaglandins"},{"key":"10.1016\/j.ejphar.2015.08.053_bib16","first-page":"74","article-title":"Effects of dopaminergic agents on visceral pain measured by the mouse writhing test","volume":"331","author":"Frussa-Filho","year":"1996","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejphar.2015.08.053_bib17","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1503\/cmaj.1041064","article-title":"Modern antipsychotic drugs: a critical overview","volume":"172","author":"Gardner","year":"2005","journal-title":"Can. Med. Assoc. J. (journal de l\u2019Association medicale canadienne)"},{"key":"10.1016\/j.ejphar.2015.08.053_bib18","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1001\/archpsyc.60.10.974","article-title":"Mechanism of new antipsychotic medications: occupancy is not just antagonism","volume":"60","author":"Grunder","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.08.053_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-0270(85)90116-5","article-title":"Formalin test in mice, a useful technique for evaluating mild analgesics","volume":"14","author":"Hunskaar","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2015.08.053_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tins.2007.03.002","article-title":"Dopamine: 50 years in perspective","volume":"30","author":"Iversen","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2015.08.053_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(02)01532-7","article-title":"The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor","volume":"441","author":"Jordan","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.4088\/JCP.v63n0903","article-title":"Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder","volume":"63","author":"Kane","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.08.053_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2004.06.005","article-title":"How antipsychotics become anti-\u201cpsychotic\u201d\u2014from dopamine to salience to psychosis","volume":"25","author":"Kapur","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2015.08.053_bib24","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1176\/appi.ajp.160.9.1651","article-title":"A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania","volume":"160","author":"Keck","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.08.053_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejphar.2007.09.016","article-title":"Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice","volume":"578","author":"Leite","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-9964(03)00050-1","article-title":"Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials","volume":"61","author":"Marder","year":"2003","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2015.08.053_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0306-4522(87)90360-5","article-title":"Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs","volume":"22","author":"Martin","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2015.08.053_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00048-3","article-title":"The induction of pain: an integrative review","volume":"57","author":"Millan","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejphar.2015.02.025","article-title":"Dopamine receptor partial agonists and addiction","volume":"752","author":"Moreira","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0091-3057(91)90560-O","article-title":"Dopamine receptor subtypes and formalin test analgesia","volume":"40","author":"Morgan","year":"1991","journal-title":"Pharmacol., Biochem., Behav."},{"key":"10.1016\/j.ejphar.2015.08.053_bib32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2007.07.062","article-title":"Dopamine D(1) and D(2) receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test","volume":"575","author":"Munro","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1124\/pr.55.4.4","article-title":"International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology","volume":"55","author":"Neubig","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2015.08.053_bib34","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1471-4159.2007.04660.x","article-title":"Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation","volume":"102","author":"Novi","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2015.08.053_bib35","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1098\/rstb.2008.0105","article-title":"Review. Evidence-based treatments of addiction","volume":"363","author":"O\u2019Brien","year":"2008","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.ejphar.2015.08.053_bib37","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/0269881105053308","article-title":"The place of partial agonism in psychiatry: recent developments","volume":"19","author":"Ohlsen","year":"2005","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejphar.2011.11.023","article-title":"Peripheral antinociception induced by delta-opioid receptors activation, but not mu- or kappa-, is mediated by Ca(2)(+)-activated Cl(\u2212) channels","volume":"674","author":"Pacheco Dda","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/syn.20616","article-title":"Human evidence of a supra-spinal modulating role of dopamine on pain perception","volume":"63","author":"Potvin","year":"2009","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2015.08.053_bib40","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejphar.2015.08.053_bib41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.niox.2011.08.002","article-title":"The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugs","volume":"25","author":"Romero","year":"2011","journal-title":"Nitric Oxide"},{"issue":"4","key":"10.1016\/j.ejphar.2015.08.053_bib100","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0306-4522(92)90213-L","article-title":"5-Hydroxytryptamine-induced sensitization and activation of peripheral fibres in the neonatal rat are mediated via different 5-hydroxytryptamine-receptors","volume":"50","author":"Rueff","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2015.08.053_bib42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1474-8673.1982.tb00520.x","article-title":"Review important concepts of receptor theory","volume":"2","author":"Ruffolo","year":"1982","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib43","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1476-5381.2008.00093.x","article-title":"The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociception","volume":"156","author":"Sachs","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib44","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandkuhler","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2015.08.053_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.expneurol.2010.12.004","article-title":"Chronic dizocilpine or apomorphine and development of neuropathy in two rat models I: behavioral effects and role of nucleus accumbens","volume":"228","author":"Sarkis","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1113\/jphysiol.1988.sp017240","article-title":"Excitation and sensitization of fine articular afferents from cat\u2019s knee joint by prostaglandin E2","volume":"403","author":"Schaible","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib47","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.npp.1300203","article-title":"Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology","volume":"28","author":"Shapiro","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2015.08.053_bib48","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4088\/JCP.v66n1002","article-title":"Aripiprazole augmentation of antidepressants for the treatment of partially responding and nonresponding patients with major depressive disorder","volume":"66","author":"Simon","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.08.053_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00213-008-1069-z","article-title":"Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice","volume":"199","author":"Sorensen","year":"2008","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.ejphar.2015.08.053_bib101","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0306-4522(92)90508-Y","article-title":"Serotonin is a directly-acting hyperalgesic agent in the rat","volume":"48","author":"Taiwo","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2015.08.053_bib50","doi-asserted-by":"crossref","first-page":"e96167","DOI":"10.1371\/journal.pone.0096167","article-title":"Dopamine precursor depletion influences pain affect rather than pain sensation","volume":"9","author":"Tiemann","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.ejphar.2015.08.053_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5897\/JMPR2013.5085","article-title":"Antinociceptive effects of Maytenus imbricata Mart. ex. Reissek (Celastraceae) root extract and its tingenone constituent","volume":"8","author":"Veloso","year":"2014","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.ejphar.2015.08.053_bib52","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/bcpt.12036","article-title":"Effects of aripiprazole, an atypical antipsychotic, on the motor alterations induced by acute ethanol administration in mice","volume":"112","author":"Viana","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2015.08.053_bib53","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1038\/sj.npp.1301353","article-title":"Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration","volume":"32","author":"Wee","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2015.08.053_bib54","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1586\/14737175.8.5.781","article-title":"Role of central dopamine in pain and analgesia","volume":"8","author":"Wood","year":"2008","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.ejphar.2015.08.053_bib55","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0306-3623(98)00250-X","article-title":"Effects of dopaminergic agents on antinociception in formalin test","volume":"32","author":"Zarrindast","year":"1999","journal-title":"Gen. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T17:55:48Z","timestamp":1537379748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915302260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":56,"alternative-id":["S0014299915302260"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.053","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}