{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:48:24Z","timestamp":1740109704136,"version":"3.37.3"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["11789","14-R97-A5232-22836"],"award-info":[{"award-number":["11789","14-R97-A5232-22836"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008390","name":"Forskerakademiet","doi-asserted-by":"publisher","award":["12-126232"],"award-info":[{"award-number":["12-126232"]}],"id":[{"id":"10.13039\/100008390","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ejphar.2015.09.043","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T04:33:14Z","timestamp":1443587594000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Impaired endothelial calcium signaling is responsible for the defective dilation of mesenteric resistance arteries from db\/db mice to acetylcholine"],"prefix":"10.1016","volume":"767","author":[{"given":"Hua","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Kold-Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael","family":"Laher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Aalkjaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.09.043_bib1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/CIRCRESAHA.109.206318","article-title":"Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone","volume":"105","author":"Ali","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.09.043_bib2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.bbrc.2003.11.034","article-title":"Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF","volume":"312","author":"Angulo","year":"2003","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.ejphar.2015.09.043_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1476-5381.2009.00525.x","article-title":"NS309 restores EDHF-typerelaxation in mesenteric small arteries from type 2 diabetic ZDF rats","volume":"159","author":"Br\u00f8ndum","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1139\/Y07-010","article-title":"Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2\/TxA2 receptor activation and cytochrome p450 products","volume":"85","author":"Cheng","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib5","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.STR.0000152952.42730.92","article-title":"Impaired endothelium- dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes","volume":"36","author":"Didion","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2015.09.043_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2007.09.001","article-title":"Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice","volume":"48","author":"Elmi","year":"2008","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.0000105763.51286.7F","article-title":"Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease","volume":"109","author":"Fichtlscherer","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2015.09.043_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/hh2101.099268","article-title":"Cytochrome p450 and vascular homeostasis","volume":"89","author":"Fleming","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.09.043_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.RES.88.1.44","article-title":"Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 C9) Is a functionally significant source of reactive oxygen species in coronary arteries","volume":"88","author":"Fleming","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.09.043_bib10","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/sj.bjp.0701258","article-title":"Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats","volume":"121","author":"Fukao","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.153.3740.1127","article-title":"Diabetes, a new mutation in the mouse","volume":"153","author":"Hummel","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2015.09.043_bib12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1089\/ars.2008.2155","article-title":"Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS leading to enhancement of nitric-oxide bioavailability and tissue oxygenation","volume":"11","author":"Khan","year":"2009","journal-title":"Antioxid. Redox. Signal"},{"key":"10.1016\/j.ejphar.2015.09.043_bib13","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1124\/jpet.107.129486","article-title":"Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species","volume":"323","author":"Khan","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.09.043_bib14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1159\/000051094","article-title":"Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries","volume":"38","author":"Lagaud","year":"2001","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.ejphar.2015.09.043_bib15","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.vph.2006.02.007","article-title":"Specific impairment of endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from streptozotocin-induced diabetic mice","volume":"44","author":"Matsumoto","year":"2006","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0003-9861(02)00548-9","article-title":"Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism- based inactivation by tienilic acid","volume":"409","author":"Melet","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2015.09.043_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejphar.2006.08.086","article-title":"Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db\/db mice","volume":"551","author":"Pannirselvam","year":"2006","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.ejphar.2015.09.043_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.atherosclerosis.2006.09.016","article-title":"Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells","volume":"193","author":"Piga","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2015.09.043_bib19","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/01.HYP.0000208299.62535.58","article-title":"Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling","volume":"47","author":"Pokreisz","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2015.09.043_bib20","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ceca.2007.01.007","article-title":"Antiphase oscillations of endothelium and smooth muscle [Ca2+]I in vasomotion of rat mesenteric small arteries","volume":"42","author":"Rahman","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2015.09.043_bib21","first-page":"H2073","article-title":"Reactive oxygen species- selective regulation of aortic inflammatory gene expression in Type 2 diabetes","volume":"292","author":"San","year":"2007","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1139\/y05-069","article-title":"Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?","volume":"83","author":"Triggle","year":"2005","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.09.043_bib23","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/ars.2009.2831","article-title":"Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in Type 2 diabetic mice","volume":"13","author":"Wong","year":"2010","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.ejphar.2015.09.043_bib24","doi-asserted-by":"crossref","first-page":"36059","DOI":"10.1074\/jbc.R100030200","article-title":"Epoxygenase pathways of arachidonic acid metabolism","volume":"276","author":"Zeldin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.09.043_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2010.12.016","article-title":"Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension","volume":"654","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915302752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:25:21Z","timestamp":1655349921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915302752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":25,"alternative-id":["S0014299915302752"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.09.043","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired endothelial calcium signaling is responsible for the defective dilation of mesenteric resistance arteries from db\/db mice to acetylcholine","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.09.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}