{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:46:40Z","timestamp":1773661600000,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ejphar.2015.11.013","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T22:19:07Z","timestamp":1448144347000},"page":"162-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["ATP is not involved in \u03b11-adrenoceptor-mediated vasoconstriction in resistance arteries"],"prefix":"10.1016","volume":"769","author":[{"given":"James A.","family":"Angus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.11.013_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1056-8719(00)00121-0","article-title":"Techniques to study the pharmacodynamics of isolated large and small blood vessels","volume":"44","author":"Angus","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejphar.2015.11.013_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2015.01.024","article-title":"Pannexin-1 channels do not regulate \u03b11-adrenoceptor-mediated vasoconstriction in resistance arteries","volume":"750","author":"Angus","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.013_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1476-5381.1959.tb00928.x","article-title":"Some quantitative uses of drug antagonists","volume":"14","author":"Arunlakshana","year":"1959","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.ejphar.2015.11.013_bib4","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1549-8719.2012.00172.x","article-title":"Characterization of the thoracodorsal artery: morphology and reactivity","volume":"19","author":"Billaud","year":"2012","journal-title":"Microcirculation"},{"key":"10.1016\/j.ejphar.2015.11.013_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tcm.2012.06.014","article-title":"Pannexin 1 in the regulation of vascular tone","volume":"22","author":"Billaud","year":"2012","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2015.11.013_bib6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.110.237594","article-title":"Pannexin1 regulates alpha1-adrenergic receptor- mediated vasoconstriction","volume":"109","author":"Billaud","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.11.013_bib7","doi-asserted-by":"crossref","first-page":"ra17","DOI":"10.1126\/scisignal.2005824","article-title":"A molecular signature in the pannexin1 intracellular loop confers channel activation by the alpha1 adrenoreceptor in smooth muscle cells","volume":"8","author":"Billaud","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ejphar.2015.11.013_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s002100100463","article-title":"NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors","volume":"364","author":"Braun","year":"2001","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.013_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0306-4522(76)90054-3","article-title":"Do some nerve cells release more than one transmitter?","volume":"1","author":"Burnstock","year":"1976","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2015.11.013_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1124\/pr.113.008029","article-title":"Purinergic signaling and blood vessels in health and disease","volume":"66","author":"Burnstock","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2015.11.013_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1476-5381.2011.01534.x","article-title":"Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop","volume":"165","author":"El-Ajouz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.013_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-1838(98)00189-1","article-title":"P2X (purinergic) receptor distributions in rat blood vessels","volume":"75","author":"Hansen","year":"1999","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.ejphar.2015.11.013_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ejmech.2004.01.007","article-title":"Structure\u2013activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist","volume":"39","author":"Kassack","year":"2004","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.11.013_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0165-1838(00)00135-1","article-title":"The novel heteromeric bivalent ligand SB9 potently antagonizes P2Y1 receptor-mediated responses","volume":"81","author":"Lambrecht","year":"2000","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.ejphar.2015.11.013_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0165-6147(00)89066-5","article-title":"Analysis of competitive agonist-antagonist interactions by nonlinear regression","volume":"16","author":"Lew","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2015.11.013_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2015.11.013_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuropharm.2004.11.003","article-title":"Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist","volume":"48","author":"Rettinger","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2015.11.013_bib18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0022-3565(25)31472-2","article-title":"Developments of computer-based estimation of pA2 values and associated analysis","volume":"207","author":"Stone","year":"1978","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2015.11.013_bib19","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1124\/mol.62.6.1438","article-title":"P2X1 receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries","volume":"62","author":"Vial","year":"2002","journal-title":"Mol. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915303514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915303514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T13:33:00Z","timestamp":1748698380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915303514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":19,"alternative-id":["S0014299915303514"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.013","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATP is not involved in \u03b11-adrenoceptor-mediated vasoconstriction in resistance arteries","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}