{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:07:11Z","timestamp":1789510031971,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,3]],"date-time":"2016-12-03T00:00:00Z","timestamp":1480723200000},"content-version":"vor","delay-in-days":368,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ejphar.2015.11.018","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T13:31:00Z","timestamp":1448371860000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Inhibitory effect of sesquiterpene lactones and the sesquiterpene alcohol aromadendrane-4\u03b2,10\u03b1-diol on memory impairment in a mouse model of Alzheimer"],"prefix":"10.1016","volume":"769","author":[{"given":"Solomon K.S.","family":"Amoah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza","family":"Dalla Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Pedrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Lazzarotto","family":"Carnhelutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Elisa","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Adolfo","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maique W.","family":"Biavatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.11.018_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-2011-101716","article-title":"Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer\u2019s disease brain mitochondria","volume":"27","author":"Alikhani","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejphar.2015.11.018_bib2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/lm.27305","article-title":"Endogenous BDNF is required for long-term memory formation in the rat parietal cortex","volume":"12","author":"Alonso","year":"2005","journal-title":"Learn. Mem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phytochem.2012.11.018","article-title":"Sesquiterpene lactones from the leaves of Hedyosmum brasiliense (Chloranthaceae)","volume":"87","author":"Amoah","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejphar.2015.11.018_bib4","first-page":"882","article-title":"Modified procedure for the estimation of reduced glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2015.11.018_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nlm.2014.02.009","article-title":"Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus","volume":"111","author":"Blank","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib6","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1021\/jo000927h","article-title":"Stereoselective synthesis of 7,11-guaien-8,12-olides from santonin. Synthesis of podoandin and (+)-zedolactone A","volume":"65","author":"Blay","year":"2000","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib7","doi-asserted-by":"crossref","first-page":"12780","DOI":"10.3390\/ijms140612780","article-title":"Sesquiterpenoids lactones: benefits to plants and people","volume":"14","author":"Chadwick","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2015.11.018_bib8","first-page":"313","article-title":"Sesquiterpene lactones: structural diversity and their biological activities, In-Opportunity, Challanges and Scope of Natural Products in Medicinal Chemistry. Research Signpost","author":"Chaturvedi","year":"2011","journal-title":"Trivandrum"},{"key":"10.1016\/j.ejphar.2015.11.018_bib9","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2174\/138955711797655399","article-title":"Natural sesquiterpenoids as cytotoxic anticancer agents","volume":"11","author":"Chen","year":"2011","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.10.056","article-title":"Oxidative stress in Alzheimer\u2019s disease","author":"Chen","year":"2014","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ejphar.2015.11.018_bib11","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.nbd.2006.02.008","article-title":"Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the rat","volume":"23","author":"Cheng","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2015.11.018_bib12","first-page":"851","article-title":"Protective effects of isoatriplicolide tiglate from Paulownia coreana against glutamate-induced neurotoxicity in primary cultured rat cortical cells","volume":"5","author":"Chung","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.ejphar.2015.11.018_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0378-8741(88)90153-5","article-title":"Screening in mice of some medicinal plants used for analgesic purposes in the state of Sao Paulo","volume":"24","author":"Di Stasi","year":"1988","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib14","doi-asserted-by":"crossref","first-page":"e79977","DOI":"10.1371\/journal.pone.0079977","article-title":"Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer\u2019s mouse brain: implication for bioenergetic intervention","volume":"8","author":"Ding","year":"2013","journal-title":"Plos. ONE"},{"key":"10.1016\/j.ejphar.2015.11.018_bib15","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1046\/j.1432-1327.2000.01597.x","article-title":"Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species","volume":"267","author":"Dringen","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib16","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s11064-012-0799-9","article-title":"Neuroprotective effect of natural products against Alzheimer\u2019s disease","volume":"37","author":"Essa","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2015.11.018_bib17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ejmech.2014.02.035","article-title":"Design, synthesis and biological evaluation of d-ring opened galantamine analogs as multifunctional anti-Alzheimer agents","volume":"76","author":"Fang","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbr.2014.06.027","article-title":"D1 and D5 dopamine receptors participate on the consolidation of two different memories","volume":"271","author":"Furini","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2015.11.018_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00210-015-1096-3","article-title":"The role of oxidative stress in anticancer activity of sesquiterpene lactones","volume":"388","author":"Gach","year":"2015","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib20","first-page":"46","article-title":"Research progress on natural products from traditional Chinese medicine in treatment of Alzheimer\u2019s disease","volume":"7","author":"Gao","year":"2013","journal-title":"Drug. Discov. Ther."},{"key":"10.1016\/j.ejphar.2015.11.018_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejphar.2011.11.009","article-title":"The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: evidence for the involvement of adrenergic, dopaminergic and serotonergic systems","volume":"674","author":"Goncalves","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib22","first-page":"44","article-title":"The mechanisms of neurodegenerative processes and current pharmacotherapy of Alzheimer\u2019s disease","author":"Gongadze","year":"2008","journal-title":"Georgian Med. News"},{"key":"10.1016\/j.ejphar.2015.11.018_bib23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1590\/0001-3765201420130005","article-title":"Natural sesquiterpene lactones as acetylcholinesterase inhibitors","volume":"86","author":"Hajimehdipoor","year":"2014","journal-title":"Acad. Bras. Ci\u00eanc."},{"key":"10.1016\/j.ejphar.2015.11.018_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/156720512799015046","article-title":"Ethnobotanical treatment strategies against Alzheimer\u2019s disease","volume":"9","author":"Howes","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejphar.2015.11.018_bib25","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2015.11.018_bib26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1752-153X-7-116","article-title":"Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa","volume":"7","author":"Ibrahim","year":"2013","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.ejphar.2015.11.018_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1155\/NP.2004.159","article-title":"Pharmacological findings on the biochemical bases of memory processes: a general view","volume":"11","author":"Izquierdo","year":"2004","journal-title":"Neural Plast."},{"key":"10.1016\/j.ejphar.2015.11.018_bib28","first-page":"2965","article-title":"Distribution of Lindenanolides in the Chloranthaceae (Organic Chemistry)","volume":"52","author":"Kawabata","year":"1988","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib29","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1111\/jphp.12090","article-title":"Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer\u2019s disease","volume":"65","author":"Konrath","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib30","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/0031-9422(92)83103-6","article-title":"Podoandin, a molluscicidal sesquiterpene lactone from Podocarpus andina","volume":"31","author":"Kubo","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejphar.2015.11.018_bib31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrneurol.2009.219","article-title":"Can Alzheimer disease be prevented by amyloid-beta immunotherapy?","volume":"6","author":"Lemere","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0098-2997(03)00025-6","article-title":"Hydroxynonenal, toxic carbonyls, and Alzheimer disease","volume":"24","author":"Liu","year":"2003","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.ejphar.2015.11.018_bib33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.arr.2011.03.002","article-title":"The role of beta-amyloid peptide in neurodegenerative diseases","volume":"10","author":"Maltsev","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ejphar.2015.11.018_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1385\/NMM:5:2:147","article-title":"Differential expression of oxidative phosphorylation genes in patients with Alzheimer\u2019s disease: implications for early mitochondrial dysfunction and oxidative damage","volume":"5","author":"Manczak","year":"2004","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.ejphar.2015.11.018_bib35","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.2174\/138945011798109437","article-title":"Perspectives on sesquiterpene lactones in inflammation and cancer","volume":"12","author":"Merfort","year":"2011","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.ejphar.2015.11.018_bib36","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1590\/S0103-50532003000500020","article-title":"Antifungal Aromadendrane Sesquiterpenoids from the Leaves of Xylopia brasiliensis","volume":"14","author":"Moreira","year":"2003","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.ejphar.2015.11.018_bib37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1196\/annals.1333.062","article-title":"Oxidative stress and neurodegeneration","volume":"1043","author":"Moreira","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2015.11.018_bib38","first-page":"51","article-title":"Neuropathological changes in brain cortex and hippocampus in a rat model of Alzheimer\u2019s disease","volume":"15","author":"Nobakht","year":"2011","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.ejphar.2015.11.018_bib39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2015.11.018_bib40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0091-3057(86)90552-6","article-title":"New adaptations in Plus-Maze laberint","volume":"24","author":"Pellow","year":"1987","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2015.11.018_bib41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2015.11.018_bib42","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.expneurol.2010.08.030","article-title":"Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-beta(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage","volume":"226","author":"Piermartiri","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbr.2006.11.032","article-title":"Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL\/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response","volume":"177","author":"Prediger","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2015.11.018_bib44","unstructured":"Reitz, R., Clorantaceas,-Flora Ilustrada Catarinense. Herb\u00e1rio \u201cBarbosa Rodrigues\u201d, Itaja\u00ed, 1965, pp. 4-10."},{"key":"10.1016\/j.ejphar.2015.11.018_bib45","first-page":"89","article-title":"Erratum: Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus (Current Drug Discovery Technologies (2005) 2, (185-193))","volume":"3","author":"Rollinger","year":"2006","journal-title":"Curr. Drug. Discov. Technol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1570163054866855","article-title":"Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus","volume":"2","author":"Rollinger","year":"2005","journal-title":"Curr. Drug. Discov. Technol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib47","series-title":"Studies in Natural Products Chemistry.","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1572-5995(06)80030-X","article-title":"Structure-activity relationships of sesquiterpene lactones","author":"Schmidt","year":"2006"},{"key":"10.1016\/j.ejphar.2015.11.018_bib48","doi-asserted-by":"crossref","first-page":"e68011","DOI":"10.1371\/journal.pone.0068011","article-title":"The role of oxidative stress in nervous system aging","volume":"8","author":"Sims-Robinson","year":"2013","journal-title":"Plos. ONE"},{"key":"10.1016\/j.ejphar.2015.11.018_bib49","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.media.2014.01.001","article-title":"Quantifying anatomical shape variations in neurological disorders","volume":"18","author":"Singh","year":"2014","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.ejphar.2015.11.018_bib50","first-page":"1651","article-title":"Current therapeutic strategy in Alzheimer\u2019s disease","volume":"16","author":"Singh","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2015.11.018_bib51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jep.2009.12.026","article-title":"Evaluation of behavioral and pharmacological effects of Hedyosmum brasiliense and isolated sesquiterpene lactones in rodents","volume":"128","author":"Tolardo","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.018_bib52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1055\/s-1999-14007","article-title":"Antinociception caused by the extract of Hedyosmum brasiliense and its active principle, the sesquiterpene lactone 13-hydroxy-8,9- dehydroshizukanolide","volume":"65","author":"Trentin","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2015.11.018_bib53","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.3390\/molecules171215013","article-title":"Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells","volume":"17","author":"Wang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2015.11.018_bib54","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.4238\/2014.March.24.8","article-title":"Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Abeta-induced cognitive disorder rats","volume":"13","author":"Yin","year":"2014","journal-title":"Genet. Mol. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915303563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915303563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T21:20:37Z","timestamp":1567372837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915303563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":54,"alternative-id":["S0014299915303563"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.018","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effect of sesquiterpene lactones and the sesquiterpene alcohol aromadendrane-4\u03b2,10\u03b1-diol on memory impairment in a mouse model of Alzheimer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}