{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:45:34Z","timestamp":1791272734787,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"TUBITAK","award":["113S193"],"award-info":[{"award-number":["113S193"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.ejphar.2015.11.054","type":"journal-article","created":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T19:30:30Z","timestamp":1448739030000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Studies on the reproductive effects of chronic treatment with agomelatine in the rat"],"prefix":"10.1016","volume":"770","author":[{"given":"Sinan","family":"Canpolat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazife","family":"Ulker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Yardimci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Bulmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokcen","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubeyde","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan","family":"Serhatlioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Kacar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mete","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaffari","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad","family":"Atmaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayram","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Kelestimur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2015.11.054_bib1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.fertnstert.2015.02.002","article-title":"Impairment of male reproductive function after sleep deprivation","volume":"103","author":"Alvarenga","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ejphar.2015.11.054_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1192\/bjp.bp.108.050955","article-title":"Melatonin and its agonists: an update","volume":"193","author":"Arendt","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.11.054_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(88)90068-4","article-title":"Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate","volume":"158","author":"Armario","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib4","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrd3274","article-title":"Agomelatine, the first melatonergic antidepressant: discovery, characterization and development","volume":"9","author":"de Bodinat","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2015.11.054_bib5","first-page":"126","article-title":"Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors","volume":"29","author":"Bourin","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.ejphar.2015.11.054_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0031-9384(99)00204-8","article-title":"Melatonin enhances sexual behavior in the male rat","volume":"68","author":"Brotto","year":"2000","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2015.11.054_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-2999(00)00491-X","article-title":"Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin","volume":"402","author":"Brotto","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/npp.2012.140","article-title":"Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain","volume":"38","author":"Chenu","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/0269881113510071","article-title":"Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons","volume":"28","author":"Chenu","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ejphar.2015.11.054_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.11.054_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00213-005-0093-5","article-title":"Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment","volume":"182","author":"Cryan","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib13","doi-asserted-by":"crossref","first-page":"S703","DOI":"10.1016\/j.euroneuro.2011.07.004","article-title":"Agomelatine: a narrative review","volume":"Suppl. 4","author":"Demyttenaere","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/mp.2011.159","article-title":"5-HT(2B) receptors are required for serotonin-selective antidepressant actions","volume":"17","author":"Diaz","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.11.054_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0006-8993(00)02715-3","article-title":"Acute low doses of melatonin restore full sexual activity in impotent male rats","volume":"29","author":"Drago","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2015.11.054_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(99)00701-3","article-title":"Acute low doses of melatonin stimulate rat sex behavior: the role of serotonin neurotransmission","volume":"26","author":"Drago","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/neu.2013.60","article-title":"Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review","volume":"26","author":"Elnazer","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.ejphar.2015.11.054_bib19","first-page":"22","article-title":"The effects of antidepressants on sexual functioning in depressed patients: a review","volume":"Suppl. 3","author":"Ferguson","year":"2001","journal-title":"J. Clin. Psychiatry 62"},{"key":"10.1016\/j.ejphar.2015.11.054_bib1000","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1210\/en.2004-0990","article-title":"Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system","volume":"146","author":"Frungieri","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1098-2396(20000601)36:3<205::AID-SYN5>3.0.CO;2-D","article-title":"Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat","volume":"36","author":"Gobert","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2015.11.054_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2147\/NDT.S4234","article-title":"New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists","volume":"5","author":"Hardeland","year":"2009","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ejphar.2015.11.054_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3109\/09513590.2010.501888","article-title":"Evaluation of melatonin on the precocious puberty: a pilot study","volume":"27","author":"de Holanda","year":"2011","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yhbeh.2007.03.030","article-title":"Sexual behavior in male rodents","volume":"52","author":"Hull","year":"2007","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ejphar.2015.11.054_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0166-4328(99)00086-8","article-title":"Hormone-neurotransmitter interactions in the control of sexual behavior","volume":"105","author":"Hull","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2015.11.054_bib25","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neubiorev.2006.01.001","article-title":"Serotonin and the neurobiology of the ejaculatory threshold","volume":"30","author":"de Jong","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2015.11.054_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/1039856214556323","article-title":"Management of antidepressant-induced sexual dysfunction","volume":"22","author":"Keks","year":"2014","journal-title":"Australas. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.11.054_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2011.11.040","article-title":"Melatonin elicits protein kinase C-mediated calcium response in immortalized GT1-7 GnRH neurons","volume":"1435","author":"Kelestimur","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2015.11.054_bib28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.euroneuro.2014.01.006","article-title":"A placebo-controlled study of three agomelatine dose regimens (10mg, 25mg, 25\u201350mg) in patients with major depressive disorder","volume":"24","author":"Kennedy","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2015.11.054_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00213-011-2597-5","article-title":"Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC","volume":"221","author":"Ladurelle","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/hup.1243","article-title":"The effects of agomelatine on sexual function in depressed patients and healthy volunteers","volume":"26","author":"Montejo","year":"2011","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/0269881108096507","article-title":"Better sexual acceptability of agomelatine (25 and 50mg) compared with paroxetine (20mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale","volume":"24","author":"Montejo","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib32","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/sj.npp.1300091","article-title":"Effect of agomelatine in the chronic mild stress model of depression in the rat","volume":"28","author":"Papp","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib33","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2015.11.054_bib35","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/00048670903107575","article-title":"Sexual side-effects of contemporary antidepressants: review","volume":"43","author":"Schweitzer","year":"2009","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.11.054_bib36","first-page":"257","article-title":"Central nervous system depressant activities of melatonin in rats and mice","volume":"36","author":"Shaji","year":"1998","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib37","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1177\/0004867413499079","article-title":"Agomelatine-induced gynaecomastia","volume":"47","author":"Tan","year":"2013","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2015.11.054_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.clnu.2007.12.006","article-title":"Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats","volume":"27","author":"Turk","year":"2008","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ejphar.2015.11.054_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00213-011-2202-y","article-title":"Evaluation of sleep, puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomnia","volume":"216","author":"van Geijlswijk","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2015.11.054_bib41","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/01.yic.0000195660.37267.cf","article-title":"Biological rhythm disturbances in mood disorders","volume":"1","author":"Wirz-Justice","year":"2006","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2015.11.054_bib42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pbb.2007.09.009","article-title":"Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats: differential roles of 5-HT2 receptor subtypes","volume":"88","author":"Yonezawa","year":"2008","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915303903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299915303903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T05:58:58Z","timestamp":1537163938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299915303903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":41,"alternative-id":["S0014299915303903"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.054","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Studies on the reproductive effects of chronic treatment with agomelatine in the rat","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}