{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:38:34Z","timestamp":1787585914928,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570514"],"award-info":[{"award-number":["81570514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500477"],"award-info":[{"award-number":["81500477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Zhejiang Province, China","award":["LY15H030017"],"award-info":[{"award-number":["LY15H030017"]}]},{"name":"Natural Science Foundation of Zhejiang Province, China","award":["LQ15H030006"],"award-info":[{"award-number":["LQ15H030006"]}]},{"name":"National Five-Year Science And Technology","award":["2013ZX10005002-001-008"],"award-info":[{"award-number":["2013ZX10005002-001-008"]}]},{"name":"National Five-Year Science And Technology","award":["2013ZX10002003"],"award-info":[{"award-number":["2013ZX10002003"]}]},{"name":"National Five-Year Science And Technology","award":["2012ZX10002004"],"award-info":[{"award-number":["2012ZX10002004"]}]},{"name":"Science and Technology Plan Project of Wenzhou","award":["Y20150014"],"award-info":[{"award-number":["Y20150014"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ejphar.2016.02.067","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T17:22:34Z","timestamp":1456939354000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Cannabinoid receptors are involved in the protective effect of a novel curcumin derivative C66 against CCl4-induced liver fibrosis"],"prefix":"10.1016","volume":"779","author":[{"given":"Si-Si","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Jie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Man","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ke","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.02.067_bib1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s10620-010-1507-8","article-title":"The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C trial cohort","volume":"56","author":"Abu Dayyeh","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2016.02.067_bib2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/liv.12263","article-title":"The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives","volume":"33","author":"Baldassarre","year":"2013","journal-title":"Liver Int.: Off. J. Int. Assoc. Study Liver"},{"key":"10.1016\/j.ejphar.2016.02.067_bib3","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1096\/fj.06-7451com","article-title":"Cannabinoid-2 receptor mediates protection against hepatic ischemia\/reperfusion injury","volume":"21","author":"Batkai","year":"2007","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib4","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1016\/j.febslet.2008.10.022","article-title":"Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells","volume":"582","author":"Bosier","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2016.02.067_bib5","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/0024-3205(95)00190-H","article-title":"Anandamide inhibits macrophage-mediated killing of tumor necrosis factor-sensitive cells","volume":"56","author":"Cabral","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2016.02.067_bib6","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3892\/ijmm.2014.1867","article-title":"Suppression of the TGF-beta\/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis","volume":"34","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2015.05.015","article-title":"c-jun N-terminal kinase attenuates TNFalpha signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells","author":"Choi","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib8","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(07)61721-8","article-title":"Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials","volume":"370","author":"Christensen","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2016.02.067_bib9","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/jphp.12283","article-title":"Curcumin affects beta-catenin pathway in hepatic stellate cell in vitro and in vivo","volume":"66","author":"Cui","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib10","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.21641","article-title":"Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa\/fa rats","volume":"46","author":"Gary-Bobo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jor.22660","article-title":"Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes","volume":"32","author":"Gomez","year":"2014","journal-title":"J. Orthop. Res.: Off. Publ. Orthop. Res. Soc."},{"key":"10.1016\/j.ejphar.2016.02.067_bib13","first-page":"401","article-title":"Deoxyschisandrin inhibits H2O2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB","volume":"26","author":"Gu","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.26598","article-title":"Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver","volume":"59","author":"Guillot","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1124\/mol.108.047035","article-title":"Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells","volume":"74","author":"Hegde","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/j.gastro.2009.09.015","article-title":"Modulation of hepatic fibrosis by c-jun-N-terminal kinase inhibition","volume":"138","author":"Kluwe","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jep.2008.04.003","article-title":"Inhibition of inducible nitric oxide synthase by acanthopanax Senticosus extract in RAW264.7 macrophages","volume":"118","author":"Lin","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib19","doi-asserted-by":"crossref","first-page":"13551","DOI":"10.1074\/jbc.M113.453811","article-title":"Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK\/c-jun\/Alox5 pathway","volume":"288","author":"Liu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2016.02.067_bib20","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/hep.24524","article-title":"Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice","volume":"54","author":"Louvet","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib21","doi-asserted-by":"crossref","first-page":"G9","DOI":"10.1152\/ajpgi.00467.2007","article-title":"Endocannabinoids and liver disease. I. Endocannabinoids and their receptors in the liver","volume":"294","author":"Mallat","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.febslet.2005.12.079","article-title":"Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition","volume":"580","author":"Nakajima","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2016.02.067_bib23","first-page":"281","article-title":"Colchicine treatment of liver fibrosis","volume":"53","author":"Nikolaidis","year":"2006","journal-title":"Hepato-Gastroenterol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib24","first-page":"828","article-title":"Effect of N-acetyl cysteine (NAC), an organosulfur compound from allium plants, on experimentally induced hepatic prefibrogenic events in Wistar rat","volume":"20","author":"Nissar","year":"2013","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.ejphar.2016.02.067_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jcmm.12175","article-title":"Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy","volume":"18","author":"Pan","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib26","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/j.1476-5381.2012.01854.x","article-title":"Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats","volume":"166","author":"Pan","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib27","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.2337\/db13-1577","article-title":"Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy","volume":"63","author":"Pan","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2016.02.067_bib28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/hep.21561","article-title":"Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon\u2013gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis","volume":"45","author":"Pockros","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2014.01.074","article-title":"Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell","volume":"728","author":"Qiu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib30","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2337\/db11-0477","article-title":"Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy","volume":"61","author":"Rajesh","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2016.02.067_bib31","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/sj.onc.1210392","article-title":"Differential regulation and properties of MAPKs","volume":"26","author":"Raman","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2016.02.067_bib32","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib33","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","author":"Seki","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib34","doi-asserted-by":"crossref","first-page":"G357","DOI":"10.1152\/ajpgi.00456.2007","article-title":"Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis","volume":"294","author":"Siegmund","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib35","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1172\/JCI42551","article-title":"Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity","volume":"120","author":"Tam","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2016.02.067_bib36","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s10620-014-3487-6","article-title":"Curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivo","volume":"60","author":"Tang","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2016.02.067_bib37","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/hep.23779","article-title":"Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration","volume":"52","author":"Teixeira-Clerc","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2016.02.067_bib38","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","article-title":"CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis","volume":"12","author":"Teixeira-Clerc","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1535370213514922","article-title":"The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression","volume":"239","author":"Wei","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1472-6882-12-156","article-title":"Inhibition by curcumin of multiple sites of the transforming growth factor\u2013beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats","volume":"12","author":"Yao","year":"2012","journal-title":"BMC Complement. Alter. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib41","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/jcmm.12286","article-title":"Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells","volume":"18","author":"Zhang","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejphar.2016.02.067_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2013.09.042","article-title":"Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro","volume":"721","author":"Zhang","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.02.067_bib43","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/gutjnl-2013-305507","article-title":"Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis","volume":"63","author":"Zhao","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2016.02.067_bib44","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","article-title":"Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice","volume":"96","author":"Zimmer","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"}],"updated-by":[{"DOI":"10.1016\/j.ejphar.2024.176713","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000}}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916301108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916301108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T01:40:37Z","timestamp":1567647637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916301108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":44,"alternative-id":["S0014299916301108"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.02.067","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ejphar.2024.176713","asserted-by":"object"}]},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid receptors are involved in the protective effect of a novel curcumin derivative C66 against CCl4-induced liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.02.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}