{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:07:25Z","timestamp":1790795245822,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"University Grant Commission, Govt. of India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.ejphar.2016.05.008","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T23:27:58Z","timestamp":1462663678000},"page":"253-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway"],"prefix":"10.1016","volume":"786","author":[{"given":"Farrah","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal Azhar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarwat","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.ejphar.2016.05.008_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-011-1051-7","article-title":"Repeated short-term stress synergizes the ROS signalling through up regulation of NFkB and iNOS expression induced due to combined exposure of trichloroethylene and UVB rays","volume":"360","author":"Ali","year":"2012","journal-title":"Mol. Cell Biochem."},{"issue":"7490","key":"10.1016\/j.ejphar.2016.05.008_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature13111","article-title":"Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma","volume":"507","author":"Bald","year":"2014","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.ejphar.2016.05.008_bib3","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.4161\/cc.21404","article-title":"Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control","volume":"11","author":"Becker","year":"2012","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.ejphar.2016.05.008_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2011.01.002","article-title":"Inhibition of topoisomerase II\u03b1: novel function of wedelolactone","volume":"303","author":"Benes","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2016.05.008_bib5","doi-asserted-by":"crossref","unstructured":"Besaratinia A., Yoon J.I., Schroeder C., Bradforth S.E., Cockburn M., Pfeifer G.P, 2011. Wavelength dependence of ultraviolet radiation-induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight. FASEB J. Sep; 25(9): 3079\u201391. Epub 2011 May 25.","DOI":"10.1096\/fj.11-187336"},{"issue":"12","key":"10.1016\/j.ejphar.2016.05.008_bib6","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1038\/sj.jid.5700340","article-title":"Oxidative stress in the pathogenesis of skin disease","volume":"126","author":"Bickers","year":"2006","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.ejphar.2016.05.008_bib7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-4632.2004.02222.x","article-title":"Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis","volume":"43","author":"Sander","year":"2004","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ejphar.2016.05.008_bib9","series-title":"Handbook of Methods for Oxygen Radical Research","first-page":"283","article-title":"Catalase activity","author":"Claiborne","year":"1985"},{"issue":"9","key":"10.1016\/j.ejphar.2016.05.008_bib10","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.3390\/ijms130910697","article-title":"Cell signaling through protein kinase C oxidation and activation","volume":"13","author":"Cosentino-Gomes","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"3\u20134","key":"10.1016\/j.ejphar.2016.05.008_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000337184","article-title":"Anti-inflammatory gallic acid and wedelolactone are G protein-coupled receptor-35 agonists","volume":"89","author":"Deng","year":"2012","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2016.05.008_bib12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fphys.2012.00368","article-title":"The Octet': eight protein kinases that control mammalian DNA replica","volume":"3","author":"Depamphilis","year":"2012","journal-title":"Front Physiol."},{"issue":"10","key":"10.1016\/j.ejphar.2016.05.008_bib13","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/sj.jid.5700858","article-title":"CGRP, PACAP, and VIP modulate Langerhans cell function by inhibiting NF-kappaB activation","volume":"127","author":"Ding","year":"2007","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.ejphar.2016.05.008_bib14","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1093\/nar\/gkr1216","article-title":"IKK\u03b1 contributes to UVB-induced VEGF expression by regulating AP-1 transactivation","volume":"40","author":"Dong","year":"2012","journal-title":"Nucleic Acids Res. A"},{"key":"10.1016\/j.ejphar.2016.05.008_bib16","first-page":"3855","article-title":"The regulation of rat liver xanthine oxidase. Conversion in vitro of enzyme activity from dehydrogenase (type D) to oxidase (type O)","volume":"244","author":"Stripe","year":"1969","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.ejphar.2016.05.008_bib18","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1089\/ars.2009.2825","article-title":"Redox control of protein kinase C: cell- and disease-specific aspects","volume":"13","author":"Giorgi","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"22","key":"10.1016\/j.ejphar.2016.05.008_bib19","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferase. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.ejphar.2016.05.008_bib20","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1182\/blood-2004-06-2435","article-title":"Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage","volume":"105","author":"Hirakawa","year":"2005","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ejphar.2016.05.008_bib21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"3","key":"10.1016\/j.ejphar.2016.05.008_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/1319-3767.54750","article-title":"Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB","volume":"15","author":"Kazi","year":"2009","journal-title":"Saudi J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.ejphar.2016.05.008_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.cdd.4401325","article-title":"Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex","volume":"11","author":"Kobori","year":"2004","journal-title":"Cell Death Differ."},{"issue":"4A","key":"10.1016\/j.ejphar.2016.05.008_bib25","first-page":"2591","article-title":"PKC-dependent modulation of IkB alpha-NFkB pathway in low metastatic B16F1 murine melanoma cells and in highly metastatic BL6 cells","volume":"18","author":"La Porta","year":"1998","journal-title":"Anticancer Res."},{"issue":"6","key":"10.1016\/j.ejphar.2016.05.008_bib27","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1751-1097.2008.00380.x","article-title":"Neutrophil infiltration in normal human skin after exposure to different ultraviolet radiation sources","volume":"84","author":"Lee","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ejphar.2016.05.008_bib28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ejmech.2012.07.041","article-title":"Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice","volume":"56","author":"Lee","year":"2012","journal-title":"Eur. J. Med Chem."},{"issue":"11","key":"10.1016\/j.ejphar.2016.05.008_bib29","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1002\/jcb.24220","article-title":"Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells","volume":"113","author":"Lim","year":"2012","journal-title":"J. Cell Biochem."},{"issue":"11","key":"10.1016\/j.ejphar.2016.05.008_bib30","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1016\/j.fct.2012.08.007","article-title":"Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity","volume":"50","author":"Liu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2016.05.008_bib33","article-title":"Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway","volume":"31","author":"Mishra","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2016.05.008_bib34","first-page":"5086","article-title":"Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer","volume":"44","author":"Mohandas","year":"1984","journal-title":"Cancer Res."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2016.05.008_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1019927616000","article-title":"Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts","volume":"238","author":"Nakao","year":"2002","journal-title":"Mol. Cell Biochem."},{"issue":"4","key":"10.1016\/j.ejphar.2016.05.008_bib37","first-page":"1233","article-title":"Effects of tumor-promoting phorbol diesters on neoplastic progression of Syrian hamster embryo cells","volume":"42","author":"O\u2019Brien","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2016.05.008_bib38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2016.05.008_bib39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/978-1-4615-0193-0_77","article-title":"Signaling pathways for TNFa-induced COX-2 expression: mediation through MAP kinases and NFkB, and inhibition by certain nonsteroidal anti-inflammatory drugs","volume":"507","author":"Paik","year":"2002","journal-title":"Adv. Exp. Med Biol."},{"issue":"2","key":"10.1016\/j.ejphar.2016.05.008_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1473-2165.2012.00614.x","article-title":"Effects of solar radiation on the skin","volume":"11","author":"Polefka","year":"2012","journal-title":"J. Cosmet. Dermatol."},{"issue":"10","key":"10.1016\/j.ejphar.2016.05.008_bib43","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1093\/carcin\/bgn180","article-title":"Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice","volume":"29","author":"Sarfaraz","year":"2008","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.ejphar.2016.05.008_bib44","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.3892\/ijo.2012.1664","article-title":"Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKC\u03b5 without inhibiting Akt","volume":"41","author":"Sarveswaran","year":"2012","journal-title":"Int J Oncol."},{"key":"10.1016\/j.ejphar.2016.05.008_bib45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1742-2094-8-104","article-title":"Cigarette smoke extract upregulates heme oxygenase-1 via PKC\/NADPH oxidase\/ROS\/PDGFR\/PI3K\/Akt pathway in mouse brain endothelial cells","volume":"8","author":"Shih","year":"2011","journal-title":"J. Neuroinflammation."},{"issue":"3","key":"10.1016\/j.ejphar.2016.05.008_bib47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/156720211796558041","article-title":"Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO\/cGMP pathway modulation","volume":"8","author":"Signorello","year":"2011","journal-title":"Curr. Neurovasc. Res."},{"issue":"10","key":"10.1016\/j.ejphar.2016.05.008_bib48","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/carcin\/21.10.1801","article-title":"Enhanced tumor growth in UV-irradiated skin is associated with an influx of inflammatory cells into the epidermis","volume":"21","author":"Sluyter","year":"2000","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.ejphar.2016.05.008_bib49","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1172\/JCI200420732","article-title":"Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+\/- mice","volume":"113","author":"Tang","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.ejphar.2016.05.008_bib51","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3109\/03639045.2011.643892","article-title":"Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity","volume":"38","author":"Upadhyay","year":"2012","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"10.1016\/j.ejphar.2016.05.008_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1742-2094-7-30","article-title":"Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation","volume":"7","author":"Wilms","year":"2010","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.ejphar.2016.05.008_bib53","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/carcin\/bgi194","article-title":"Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways","volume":"26","author":"Won","year":"2005","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.ejphar.2016.05.008_bib54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0003-9861(81)90095-3","article-title":"Cytosolic factors which affect microsomal lipid peroxidation in lung and liver","volume":"206","author":"Wright","year":"1981","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.ejphar.2016.05.008_bib57","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-0781.2010.00522.x","article-title":"Ultraviolet B-induced apoptosis of human skin fibroblasts involves activation of caspase-8 and \u22123 with increased expression of vimentin","volume":"26","author":"Xu","year":"2010","journal-title":"Photo. Photo. Photomed."},{"issue":"2","key":"10.1016\/j.ejphar.2016.05.008_bib59","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.taap.2013.03.015","article-title":"Quercitrin protects skin from UVB-induced oxidative damage","volume":"269","author":"Yin","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916303107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916303107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T15:34:01Z","timestamp":1655739241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916303107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"alternative-id":["S0014299916303107"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.05.008","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}