{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:55:00Z","timestamp":1789736100987,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1072706"],"award-info":[{"award-number":["1072706"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ejphar.2016.05.013","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T13:48:56Z","timestamp":1463060936000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum"],"prefix":"10.1016","volume":"784","author":[{"given":"Morgan H.","family":"James","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikki K.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Kooi","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip W.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V.","family":"Dayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.05.013_bib1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nn2054","article-title":"CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking","volume":"11","author":"Anderson","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1369-1600.2010.00311.x","article-title":"Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization","volume":"17","author":"Bailey","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2008.10.034","article-title":"The integrative function of the basal ganglia in instrumental conditioning","volume":"199","author":"Balleine","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2016.05.013_bib4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nn.3439","article-title":"Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse","volume":"16","author":"Barak","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib5","first-page":"1099","article-title":"Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals","volume":"14","author":"Brown","year":"2011","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Coll. Int. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1742-7843.2009.00427.x","article-title":"Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK\/HlJ mice","volume":"105","author":"Chang","year":"2009","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-4328(99)00051-0","article-title":"The involvement of the mediodorsal nucleus of the thalamus and the midbrain extrapyramidal area in locomotion elicited from the ventral pallidum","volume":"104","author":"Churchill","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2016.05.013_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature06995","article-title":"Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving","volume":"454","author":"Conrad","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2016.05.013_bib9","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/npp.2014.37","article-title":"Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine","volume":"39","author":"Corbit","year":"2014","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib10","first-page":"8","article-title":"Habitual responding for alcohol depends upon both AMPA and D2 receptor signaling in the dorsolateral striatum","author":"Corbit","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake","volume":"312","author":"Cota","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2016.05.013_bib12","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.1523\/JNEUROSCI.5900-08.2009","article-title":"Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism","volume":"29","author":"Cozzoli","year":"2009","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphar.2012.00013","article-title":"An emerging role for the mammalian target of rapamycin in \u201cpathological\u201d protein translation: relevance to cocaine addiction","volume":"3","author":"Dayas","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib14","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1111\/j.1476-5381.2011.01716.x","article-title":"Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats","volume":"165","author":"Deblon","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib15","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.neubiorev.2013.02.010","article-title":"From the ventral to the dorsal striatum: devolving views of their roles in drug addiction","volume":"37","author":"Everitt","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2016.05.013_bib16","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuropharm.2011.01.021","article-title":"Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca(2)(+)-permeable AMPA receptors during the incubation of cocaine craving","volume":"61","author":"Ferrario","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2016.05.013_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1601-183X.2010.00647.x","article-title":"Accumbens homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?","volume":"10","author":"Goulding","year":"2011","journal-title":"Genes Brain, Behav."},{"key":"10.1016\/j.ejphar.2016.05.013_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jchemneu.2003.10.003","article-title":"The primate basal ganglia: parallel and integrative networks","volume":"26","author":"Haber","year":"2003","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.ejphar.2016.05.013_bib19","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1523\/JNEUROSCI.20-06-02369.2000","article-title":"Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum","volume":"20","author":"Haber","year":"2000","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib20","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2016.05.013_bib21","doi-asserted-by":"crossref","first-page":"e93691","DOI":"10.1371\/journal.pone.0093691","article-title":"Single rapamycin administration induces prolonged downward shift in defended body weight in rats","volume":"9","author":"Hebert","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2016.05.013_bib22","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1523\/JNEUROSCI.0995-04.2004","article-title":"Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression","volume":"24","author":"Hou","year":"2004","journal-title":"J. Neurosci: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib23","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nn977","article-title":"Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization","volume":"5","author":"Izzo","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroscience.2011.09.047","article-title":"Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei","volume":"199","author":"James","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2016.05.013_bib25","doi-asserted-by":"crossref","first-page":"e12980","DOI":"10.1371\/journal.pone.0012980","article-title":"Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour","volume":"5","author":"James","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2016.05.013_bib26","first-page":"684","article-title":"Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking","volume":"14","author":"James","year":"2011","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Coll. Int. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib27","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1038\/npp.2014.16","article-title":"mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse\u2019 and is associated with reductions in GluA1 AMPAR and CAMKIIalpha levels","volume":"39","author":"James","year":"2014","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib28","first-page":"239","article-title":"Characterization of calcium\/calmodulin-stimulated protein kinase II","volume":"41","author":"Jarvie","year":"1995","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib29","first-page":"127","article-title":"Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats","volume":"17","author":"Lin","year":"2014","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Coll. Int. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2016.05.013_bib30","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1046\/j.1471-4159.2003.01824.x","article-title":"Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats","volume":"85","author":"Lu","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2016.05.013_bib31","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.1142365","article-title":"Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area","volume":"317","author":"Mameli","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2016.05.013_bib32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuron.2011.10.012","article-title":"Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons","volume":"72","author":"Mazei-Robison","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2016.05.013_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.neuroscience.2004.12.050","article-title":"Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats","volume":"132","author":"Narita","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2016.05.013_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/jnc.12725","article-title":"mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse","volume":"130","author":"Neasta","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2016.05.013_bib35","doi-asserted-by":"crossref","first-page":"20093","DOI":"10.1073\/pnas.1005554107","article-title":"Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders","volume":"107","author":"Neasta","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2016.05.013_bib500","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.ejphar.2016.05.013_bib37","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1073\/pnas.121145898","article-title":"The target of rapamycin (TOR) proteins","volume":"98","author":"Raught","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2016.05.013_bib39","doi-asserted-by":"crossref","first-page":"e6007","DOI":"10.1371\/journal.pone.0006007","article-title":"BDNF activates mTOR to regulate GluR1 expression required for memory formation","volume":"4","author":"Slipczuk","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2016.05.013_bib40","doi-asserted-by":"crossref","first-page":"12632","DOI":"10.1523\/JNEUROSCI.1264-10.2010","article-title":"Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats","volume":"30","author":"Wang","year":"2010","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tins.2010.06.003","article-title":"The Bermuda Triangle of cocaine-induced neuroadaptations","volume":"33","author":"Wolf","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2016.05.013_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroscience.2010.10.041","article-title":"Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization","volume":"172","author":"Wu","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2016.05.013_bib44","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2012.03.043","article-title":"Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons","volume":"75","author":"Yang","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2016.05.013_bib45","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1113\/jphysiol.2012.230268","article-title":"Cocaine potentiates excitatory drive in the perifornical\/lateral hypothalamus","volume":"590","author":"Yeoh","year":"2012","journal-title":"J. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991630317X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991630317X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T11:47:30Z","timestamp":1567856850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991630317X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":43,"alternative-id":["S001429991630317X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.05.013","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2016 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}