{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:10:57Z","timestamp":1773004257229,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002957","name":"TU Dresden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ejphar.2016.06.050","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T05:03:17Z","timestamp":1467262997000},"page":"286-293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Block of Na + \/Ca 2+ exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation"],"prefix":"10.1016","volume":"788","author":[{"given":"Torsten","family":"Christ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoly","family":"Acsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Knaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eschenhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Jost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Varr\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Wettwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Ravens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.06.050_bib1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pharmthera.2011.12.001","article-title":"Alternative strategies in arrhythmia therapy: evaluation of Na\/Ca exchange as an anti-arrhythmic target","volume":"134","author":"Antoons","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2016.06.050_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1006\/jmcc.2002.1530","article-title":"Cardiac Na\/Ca exchange function in rabbit, mouse and man: what\u2019s the difference?","volume":"34","author":"Bers","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1254\/jphs.CPJ06001X","article-title":"Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts","volume":"100","author":"Bers","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2016.06.050_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00210-005-1079-x","article-title":"Effects of SEA0400 and KBR7943 on Na+\/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes","volume":"372","author":"Birinyi","year":"2005","journal-title":"Naunyn Schmiede. Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2016.06.050_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00395-003-0409-8","article-title":"Remodeling of cardiomyocyte ion channels in human atrial fibrillation","volume":"98","author":"Dobrev","year":"2003","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/FJC.0b013e318171924d","article-title":"Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics","volume":"52","author":"Dobrev","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcm.2010.03.004","article-title":"Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation","volume":"20","author":"Dobrev","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2016.06.050_bib9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.CIR.102.6.692","article-title":"G-Protein \u03b23-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currents","volume":"102","author":"Dobrev","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.06.050_bib10","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCULATIONAHA.106.636845","article-title":"Molecular determinants of altered Ca2+ handling in humanchronic atrial fibrillation","volume":"114","author":"El Armouche","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.06.050_bib11","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1172\/JCI70102","article-title":"Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes","volume":"124","author":"Greiser","year":"2014","journal-title":"J. Clin. Investig."},{"issue":"Suppl. 2","key":"10.1016\/j.ejphar.2016.06.050_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00795357","article-title":"Calcium cycling proteins and force-frequency relationship in heart failure","volume":"91","author":"Hasenfuss","year":"1996","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib13","doi-asserted-by":"crossref","first-page":"C1167","DOI":"10.1152\/ajpcell.00288.2004","article-title":"New insights into the molecular and cellular workings of the cardiac Na+\/Ca2+ exchanger","volume":"287","author":"Hilgemann","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1085\/jgp.100.6.933","article-title":"Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP","volume":"100","author":"Hilgemann","year":"1992","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1085\/jgp.100.6.905","article-title":"Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation","volume":"100","author":"Hilgemann","year":"1992","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib16","first-page":"H2164","article-title":"Inhibition by external Cd2+ of Na\/Ca exchange and L-type Ca channel in rabbit ventricular myocytes","volume":"272","author":"Hobai","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1006\/jmcc.1994.1119","article-title":"Comparison of the action potential prolonging and positive inotropic activity of DPI 201-106 and BDF 9148 in human ventricular myocardium","volume":"26","author":"Hoey","year":"1994","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2174\/187152907781745288","article-title":"Na+\/Ca2+ exchange inhibitors: a new class of calcium regulators","volume":"7","author":"Iwamoto","year":"2007","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"10.1016\/j.ejphar.2016.06.050_bib19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1124\/jpet.104.070805","article-title":"Inhibitory profile of SEA0400 [2-[4-[(2,5-difluorophenyl)methoxy]-phenoxy]-5-ethoxyaniline] assessed on the cardiac Na+-Ca2+ exchanger NCX1.1","volume":"311","author":"Lee","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2016.06.050_bib20","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1113\/jphysiol.2014.279810","article-title":"Species-dependent adaptation of the cardiac Na+\/K+ pump kinetics to the intracellular Na+ concentration","volume":"592","author":"Lewalle","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fphar.2014.00026","article-title":"Effects of IKur blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation","volume":"5","author":"Loose","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib22","doi-asserted-by":"crossref","first-page":"e0116395","DOI":"10.1371\/journal.pone.0116395","article-title":"Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins","volume":"10","author":"Lugenbiel","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.06.050_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-3565(24)29375-7","article-title":"SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models","volume":"298","author":"Matsuda","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2016.06.050_bib24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1254\/jphs.FP0040512","article-title":"Antiarrhythmic properties of a priororal loading of amiodarone in in vivo canine coronary ligation\/reperfusioninduced arrhythmia model: comparison with other class III antiarrhythmic drugs","volume":"97","author":"Nagasawa","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2016.06.050_bib25","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1111\/bph.12867","article-title":"Selective Na+\/Ca2+ exchanger inhibition prevents Ca2+ overload-induced triggered arrhythmias","volume":"171","author":"Nagy","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/sj.bjp.0706026","article-title":"Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early and delayed after depolarization in canine heart","volume":"143","author":"Nagy","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib27","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCRESAHA.109.203836","article-title":"CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation","volume":"106","author":"Neef","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.06.050_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/00003495-200363050-00001","article-title":"Clinical potential of sodium-calcium exchanger inhibitors as antiarrhythmic agents","volume":"63","author":"Pogwizd","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2016.06.050_bib29","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0008-6363(02)00735-6","article-title":"Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis","volume":"57","author":"Pogwizd","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2016.06.050_bib30","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/hh1101.091193","article-title":"Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness","volume":"88","author":"Pogwizd","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.06.050_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00395-012-0247-7","article-title":"Proarrhythmia in a non-failing murine model of cardiac-specific Na+\/Ca2+ exchanger overexpression: whole heart and cellular mechanisms","volume":"107","author":"Pott","year":"2012","journal-title":"Basic Res. Cardiol."},{"issue":"Suppl 3","key":"10.1016\/j.ejphar.2016.06.050_bib32","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1097\/00005344-198914003-00007","article-title":"Modulation of sodium\/calcium exchange: a hypothetical positive inotropic mechanism","volume":"14","author":"Ravens","year":"1989","journal-title":"J. Cardiovasc. Pharm."},{"key":"10.1016\/j.ejphar.2016.06.050_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2009","article-title":"Pathophysiological mechanisms of atrial fibrillation: a translational appraisal","volume":"91","author":"Schotten","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2016.06.050_bib34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0008-6363(01)00453-9","article-title":"Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort","volume":"53","author":"Schotten","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2016.06.050_bib35","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1161\/01.RES.87.11.966","article-title":"Local Ca2+ release in heart failure: timing is important","volume":"87","author":"Sipido","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.06.050_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/3-540-29715-4_6","article-title":"Sodium calcium exchange as a target for antiarrhythmic therapy","author":"Sipido","year":"2006","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib37","first-page":"215","article-title":"Comparison of the efficiency of Na+\/Ca2+ exchanger or Na+\/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias","volume":"66","author":"Szepesi","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib38","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.bjp.0704574","article-title":"Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents","volume":"135","author":"Tanaka","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.06.050_bib39","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1161\/01.CIR.0000162461.67140.4C","article-title":"Defective cardiac ryanodine receptor regulation during atrial fibrillation","volume":"111","author":"Vest","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.06.050_bib40","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1161\/CIRCULATIONAHA.111.067306","article-title":"Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation","volume":"125","author":"Voigt","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.06.050_bib41","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1172\/JCI46315","article-title":"Recent advances in the molecular pathophysiology of atrial fibrillation","volume":"121","author":"Wakili","year":"2011","journal-title":"J. Clin. Investig."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916304095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916304095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:19:12Z","timestamp":1748992752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916304095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":41,"alternative-id":["S0014299916304095"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.06.050","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Block of Na+\/Ca2+ exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.06.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}