{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:06:49Z","timestamp":1790946409374,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"crossref","award":["TO2014TR3041"],"award-info":[{"award-number":["TO2014TR3041"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["563899\/2010-7"],"award-info":[{"award-number":["563899\/2010-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004842","name":"Universidade Paranaense","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004842","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ejphar.2016.08.006","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T19:49:03Z","timestamp":1470340143000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Nitric oxide and K ir 6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of rats"],"prefix":"10.1016","volume":"788","author":[{"given":"Arquimedes","family":"Gasparotto Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00ea","family":"dos Reis Piornedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Assreuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo","family":"Da Silva-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.08.006_bib1","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.91.16.7583","article-title":"Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K+ channel by cGMP-dependent protein kinase","volume":"91","author":"Archer","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2016.08.006_bib2","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib3","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.3390\/molecules17055757","article-title":"Protective effects of extracts and flavonoids isolated from Scutia buxifolia Reissek against chromosome damage in human lymphocytes exposed to hydrogen peroxide","volume":"17","author":"Boligon","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2016.08.006_bib4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/368850a0","article-title":"Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle","volume":"368","author":"Bolotina","year":"1994","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ejphar.2016.08.006_bib5","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1440-1681.1996.tb01172.x","article-title":"Potassium channels in vascular smooth muscle","volume":"23","author":"Brayden","year":"1996","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib6","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3945\/jn.115.211888","article-title":"Supplementation of the pure flavonoids epicatechin and quercetin affects some biomarkers of endothelial dysfunction and inflammation in (Pre) hypertensive adults: a randomized double-blind, placebo-controlled, crossover trial","volume":"145","author":"Dower","year":"2015","journal-title":"J. Nutr."},{"key":"10.1016\/j.ejphar.2016.08.006_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3177\/jnsv.53.68","article-title":"Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats","volume":"53","author":"Emura","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tox.2013.01.002","article-title":"Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a twostage hepatocarcinogenesis model using rats","volume":"305","author":"Fujii","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2016.08.006_bib9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jep.2010.12.009","article-title":"Diuretic and potassium-sparing effect of isoquercitrin-an active flavonoid of Tropaeolum majus L.","volume":"134","author":"Gasparotto","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2010.12.026","article-title":"Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme","volume":"134","author":"Gasparotto","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jep.2012.03.018","article-title":"Mechanisms underlying the diuretic effects of Tropaeolum majus L. extracts and its main component isoquercitrin","volume":"141","author":"Gasparotto","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.fct.2003.10.006","article-title":"Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats","volume":"42","author":"Hasumura","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpba.2013.06.019","article-title":"A sensitive LC-MS\/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves","volume":"84","author":"He","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2016.08.006_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuint.2010.08.005","article-title":"Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative induced damage to a transformed cell line (RGC-5 cells)","volume":"57","author":"Jung","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2016.08.006_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s10059-013-0031-z","article-title":"Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-kappaB\/CRE\/AP-1 signaling in murine macrophages","volume":"35","author":"Kim","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1016\/j.ejphar.2016.08.006_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1540\/jsmr.44.65","article-title":"Physiological roles of K+ channels in vascular smooth muscle cells","volume":"44","author":"Ko","year":"2008","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.ejphar.2016.08.006_bib17","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.tiv.2008.07.013","article-title":"Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells","volume":"22","author":"Kong","year":"2008","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ejphar.2016.08.006_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.01.020","article-title":"Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNF alpha-signaling due to oxidative cellular stress in rats","volume":"283","author":"Kuwata","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2016.08.006_bib19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/bmc.942","article-title":"HPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum Thunb. extract","volume":"22","author":"Li","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejphar.2016.08.006_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-011-0613-2","article-title":"In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney","volume":"383","author":"Li","year":"2011","journal-title":"Naunyn-Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.1965.sp007572","article-title":"The Effect of Sympathetic Nerve Stimulation of Vasoconstrictor Responses in Perfused Mesenteric Blood Vessels of the Rat","volume":"177","author":"Mcgregor","year":"1965","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/10715760000301181","article-title":"Quercetin 3-O-b-glucoside is better absorbed than other quercetin forms and is not present in rat plasma","volume":"33","author":"Morand","year":"2000","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejphar.2016.08.006_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.lfs.2003.06.036","article-title":"Inhibitory effect of quercetin on carrageenan-induced inflammation in rats","volume":"74","author":"Morikawa","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2016.08.006_bib24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00204-011-0696-z","article-title":"Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats","volume":"85","author":"Morita","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpba.2013.10.037","article-title":"Simultaneous quantification and peroxynitrite-scavenging activities of flavonoids in Polygonum aviculare L. herb","volume":"89","author":"Nugroho","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2016.08.006_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/biof.5520310307","article-title":"Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside","volume":"31","author":"Panda","year":"2007","journal-title":"Biofactors"},{"key":"10.1016\/j.ejphar.2016.08.006_bib27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1476-5381.1988.tb11686.x","article-title":"Actions mediated by P2-purinoceptor subtypes in the isolated perfused mesenteric bed of the rat","volume":"95","author":"Ralevic","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib28","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/sj.bjc.6600295","article-title":"Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)","volume":"86","author":"Salucci","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejphar.2016.08.006_bib29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00005344-199611000-00014","article-title":"The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation","volume":"28","author":"Shimokawa","year":"1996","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00005344-200211000-00008","article-title":"Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features","volume":"40","author":"Taubert","year":"2002","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fct.2014.03.018","article-title":"Isoquercitrin: pharmacology, toxicology, and metabolism","volume":"68","author":"Valentov\u00e1","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2016.08.006_bib32","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1253\/circj.67.572","article-title":"Endothelial control of vasomotor function: from health to coronary disease","volume":"67","author":"Vanhoutte","year":"2003","journal-title":"Circ. J."},{"key":"10.1016\/j.ejphar.2016.08.006_bib33","first-page":"185","article-title":"Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium","volume":"3","author":"Wallner","year":"1995","journal-title":"Recept. Channels"},{"key":"10.1016\/j.ejphar.2016.08.006_bib34","doi-asserted-by":"crossref","first-page":"C561","DOI":"10.1111\/j.1750-3841.2008.00862.x","article-title":"Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay","volume":"73","author":"Yokohira","year":"2008","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ejphar.2016.08.006_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10337-010-1879-0","article-title":"A sensitive LC-MS-MS method for simultaneous quantification of two structural isomers, hyperoside and isoquercitrin: application to pharmacokinetic studies","volume":"73","author":"Zhou","year":"2011","journal-title":"Chromatographia"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991630512X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991630512X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T01:08:42Z","timestamp":1568250522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991630512X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"alternative-id":["S001429991630512X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.08.006","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide and Kir6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}