{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:13:02Z","timestamp":1762431182708},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ejphar.2016.10.006","type":"journal-article","created":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T22:10:46Z","timestamp":1476051046000},"page":"640-646","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Antispasmodic effect of selected Citrus flavonoids on rat isolated jejunum specimens"],"prefix":"10.1016","volume":"791","author":[{"given":"Marta","family":"Mendel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Ch\u0142opecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Dziekan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Karlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.10.006_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0009-9236(96)90164-2","article-title":"Flavanone absorption after naringin, hesperidin, and citrus administration","volume":"60","author":"Ameer","year":"1996","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2016.10.006_bib2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejphar.2008.09.021","article-title":"Relaxant effects of flavonoids on the mouse isolated stomach: structure-activity relationships","volume":"599","author":"Amira","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00210-004-0964-z","article-title":"Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels","volume":"370","author":"Calderone","year":"2004","journal-title":"Naunyn-Schmiedeber Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib4","first-page":"71","article-title":"The epidemiology of irritable bowel syndrome","volume":"6","author":"Canavan","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00210-007-0230-2","article-title":"Inhibitory effect of the herbal antidepressant St. Jahn's wort (Hypericum perforatum) on gastric motility","volume":"376","author":"Capasso","year":"2008","journal-title":"Naunyn-Schmiedeber Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1113\/jphysiol.1995.sp020669","article-title":"Multiple components of delayed rectifier K+ current in canine colonic smooth muscle","volume":"484","author":"Carl","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ptr.2660","article-title":"Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo","volume":"23","author":"Chen","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2016.10.006_bib8","first-page":"566","article-title":"Double-blind, placebo-controlled evaluation of clinical activity and safety of daflon 500mg in the treatment of acute hemorrhoids","volume":"45","author":"Cospite","year":"1994","journal-title":"Angiology"},{"key":"10.1016\/j.ejphar.2016.10.006_bib9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0016-5085(95)90296-1","article-title":"Eicosanoids and the gastrointestinal tract","volume":"109","author":"Eberhart","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2016.10.006_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1074","article-title":"Chemistry and Pharmacology of the citrus bioflavonoid hesperidin","volume":"15","author":"Garg","year":"2001","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2016.10.006_bib11","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3390\/12081641","article-title":"Flavonoid composition of Citrus juices","volume":"12","author":"Gattuso","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2016.10.006_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000074237","article-title":"Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein","volume":"70","author":"Gharzouli","year":"2004","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2016.10.006_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/13880200490893483","article-title":"Flavonoids and cardiovascular disease","volume":"42","author":"Gross","year":"2004","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib14","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1021\/jf990153+","article-title":"Quantification of flavonoids constituents in citrus fruits","volume":"47","author":"Kawaii","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2016.10.006_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1254\/jphs.FPJ04056X","article-title":"Effects of Rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by NG-nitro-L-arginine","volume":"98","author":"Kido","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2016.10.006_bib16","first-page":"22","article-title":"A brief evidence-based review of two gastrointestinal illnesses: irritable bowel and leaky gut syndromes","volume":"10","author":"Kiefer","year":"2004","journal-title":"Altern. Ther. Health Med."},{"key":"10.1016\/j.ejphar.2016.10.006_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF03216747","article-title":"Intestinal bacterial metabolism of flavonoids and its relation to some biological activities","volume":"21","author":"Kim","year":"1998","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejphar.2016.10.006_bib18","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1113\/jphysiol.1995.sp021087","article-title":"Nitric oxide activates multiple potassium channels in canine colonic smooth muscle","volume":"489","author":"Koh","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1248\/bpb.26.747","article-title":"Degradation of flavonoid aglycones by rabbit, rat and human fecal flora","volume":"26","author":"Lin","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2016.10.006_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejphar.2014.03.057","article-title":"Hesperetin inhibits rat coronary constriction by inhibiting Ca2+ influx and enhancing voltage-gated K+ channel currents of the myocytes","volume":"735","author":"Liu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib21","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","article-title":"Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis","volume":"10","author":"Lovell","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00210-004-0994-6","article-title":"Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin","volume":"370","author":"Orallo","year":"2004","journal-title":"Naunyn-Schmiedeberg Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-2005-837774","article-title":"Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruit flavonoid (\u00b1)-naringenin","volume":"71","author":"Orallo","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2016.10.006_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ptr.5256","article-title":"Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models","volume":"29","author":"Parhiz","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2016.10.006_bib25","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/ptr.5023","article-title":"Novel insights into the pharmacology of flavonoids","volume":"27","author":"Romano","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2016.10.006_bib26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.12.030","article-title":"Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases","volume":"124","author":"Roohbakhsh","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2016.10.006_bib27","first-page":"533","article-title":"Organization and electrophysiology of interstitial cells of Cajal and smooth muscle cells in the gastrointestinal tract","volume":"1","author":"Sanders","year":"2006"},{"key":"10.1016\/j.ejphar.2016.10.006_bib28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ptr.5292","article-title":"Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model","volume":"29","author":"Seyedrezazadeh","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2016.10.006_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/bmc.1092","article-title":"Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC\/MS method: in vivo metabolic reduction of diosmetin to hesperetin","volume":"23","author":"Spanakis","year":"2009","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejphar.2016.10.006_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1039\/c2fo10224b","article-title":"Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites","volume":"3","author":"Takumi","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2016.10.006_bib31","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s002689900145","article-title":"Low-molecular-weight heparins and daflon for prevention of postoperative thromboembolism","volume":"20","author":"Tsimoyiannis","year":"1996","journal-title":"World J. Surg."},{"key":"10.1016\/j.ejphar.2016.10.006_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1365-2680.2000.00183.x","article-title":"Potassium channels in gastrointestinal smooth muscle","volume":"20","author":"Vogalis","year":"2000","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib33","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1476-5381.1992.tb13409.x","article-title":"Involvement of cyclic GMP in non-adrenergic, non-cholinergic inhibitory neurotransmission in dog proximal colon","volume":"107","author":"Ward","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.006_bib34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.jep.2014.06.053","article-title":"Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle","volume":"155","author":"Yang","year":"2014","journal-title":"J. Ethnopharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916306471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916306471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T07:42:57Z","timestamp":1572594177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916306471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":34,"alternative-id":["S0014299916306471"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.10.006","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antispasmodic effect of selected Citrus flavonoids on rat isolated jejunum specimens","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}