{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:32:59Z","timestamp":1792153979750,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation, UK","doi-asserted-by":"publisher","award":["FS\/13\/10\/30021"],"award-info":[{"award-number":["FS\/13\/10\/30021"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/J007226\/1"],"award-info":[{"award-number":["BB\/J007226\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ejphar.2016.10.008","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T20:13:19Z","timestamp":1476216799000},"page":"659-668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels"],"prefix":"10.1016","volume":"791","author":[{"given":"Harry Z.E.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi S.","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-S.","family":"Vanessa Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.10.008_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/cvr\/cvn279","article-title":"Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells","volume":"81","author":"Alam","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2016.10.008_bib2","doi-asserted-by":"crossref","first-page":"R1020","DOI":"10.1152\/ajpregu.00238.2010","article-title":"Acute activation of the calcium-sensing receptor inhibits plasma renin activity in vivo","volume":"299","author":"Atchison","year":"2010","journal-title":"AJP Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1124\/jpet.113.205534","article-title":"Nitric-oxide synthase knockout modulates Ca2+-sensing receptor expression and signaling in mouse mesenteric arteries","volume":"346","author":"Awumey","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2016.10.008_bib4","doi-asserted-by":"crossref","first-page":"e30682","DOI":"10.1371\/journal.pone.0030682","article-title":"Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells","volume":"7","author":"Bonomini","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.10.008_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.2001.81.1.239","article-title":"Extracellular calcium sensing and extracellular calcium signaling","volume":"81","author":"Brown","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2016.10.008_bib6","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/01.HYP.30.6.1431","article-title":"Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries","volume":"30","author":"Bukoski","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2016.10.008_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/hy0202.102702","article-title":"CB(1) receptor antagonist SR141716A inhibits Ca(2+)-induced relaxation in CB(1) receptor-deficient mice","volume":"39","author":"Bukoski","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2016.10.008_bib8","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/j.transproceed.2009.06.167","article-title":"Treatment of persistent hyperparathyroidism in renal transplant patients with cinacalcet improves control of blood pressure","volume":"41","author":"Carrasco","year":"2004","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.ejphar.2016.10.008_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ki.2009.481","article-title":"Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells","volume":"77","author":"Chen","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2016.10.008_bib10","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1177\/1933719112468949","article-title":"The effects of extracellular calcium-sensing receptor ligands on the contractility of pregnant human myometrium in vitro","volume":"20","author":"Crankshaw","year":"2013","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ejphar.2016.10.008_bib11","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/CIRCRESAHA.108.172379","article-title":"Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries","volume":"102","author":"Dora","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.10.008_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ceca.2009.09.004","article-title":"Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor","volume":"46","author":"Faure","year":"2009","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2016.10.008_bib13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bone.2011.06.017","article-title":"Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: results of a randomized, double blinded, placebo-controlled Phase II clinical trial","volume":"49","author":"Fitzpatrick","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2016.10.008_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2016.01.001","article-title":"Stimulation of calcium-sensing receptors induces endotheliumdependent vasorelaxations via nitric oxide production and activation of IKCa channels","author":"Greenberg","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1742-1241.2011.02837.x","article-title":"Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials","volume":"66","author":"Han","year":"2012","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.ejphar.2016.10.008_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.med.57.121304.131328","article-title":"Therapeutic use of calcimimetics","volume":"57","author":"Hebert","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ejphar.2016.10.008_bib17","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrm1154","article-title":"Extracellular calcium sensing and signalling","volume":"4","author":"Hofer","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0022-3565(24)38130-3","article-title":"A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation","volume":"289","author":"Ishioka","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2016.10.008_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/157015907781695982","article-title":"Allosteric modulation of the calcium-sensing receptor","volume":"5","author":"Jensen","year":"2007","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib20","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3762\/bjoc.9.154","article-title":"Synthesis of the calcilytic ligand NPS 2143","volume":"9","author":"Johansson","year":"2013","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.ejphar.2016.10.008_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bone.2014.04.015","article-title":"AXT914 a novel, orallyactive parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women","volume":"64","author":"John","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2016.10.008_bib22","doi-asserted-by":"crossref","first-page":"e115178","DOI":"10.1371\/journal.pone.0115178","article-title":"Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia","volume":"9","author":"Letz","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.10.008_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1423-0127-18-16","article-title":"The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells","volume":"18","author":"Li","year":"2011","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2016.10.008_bib24","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/FJC.0b013e31828d0fa3","article-title":"Ca2+-sensing receptor cleavage by calpain partially accounts for altered vascular reactivity in mice fed a high-fat diet","volume":"61","author":"Loot","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/mgme.1998.2716","article-title":"Activating mutations of the Ca2+-sensing receptor","volume":"64","author":"Mancilla","year":"1998","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ejphar.2016.10.008_bib26","doi-asserted-by":"crossref","first-page":"F946","DOI":"10.1152\/ajprenal.00474.2006","article-title":"Extracellular calcium-sensing receptor is functionally expressed in human artery","volume":"293","author":"Molostvov","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000185484","article-title":"Extracellular calcium-sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis","volume":"22","author":"Molostvov","year":"2008","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2016.10.008_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.10.008_bib29","first-page":"H1655","article-title":"Effect of chronic sensory denervation on Ca(2+)-induced relaxation of isolated mesenteric resistance arteries","volume":"274","author":"Mupanomunda","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib30","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1073\/pnas.95.7.4040","article-title":"Calcimimetics with potent and selective activity on the parathyroid calcium receptor","volume":"95","author":"Nemeth","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2016.10.008_bib31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-3565(24)29333-2","article-title":"Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone","volume":"299","author":"Nemeth","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2016.10.008_bib32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1681\/ASN.2005090914","article-title":"Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats","volume":"17","author":"Odenwald","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib33","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/01.ASN.0000056188.23717.E5","article-title":"Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors","volume":"14","author":"Ogata","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib34","doi-asserted-by":"crossref","first-page":"49487","DOI":"10.1074\/jbc.M308010200","article-title":"Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor","volume":"278","author":"Petrel","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2016.10.008_bib35","doi-asserted-by":"crossref","first-page":"18990","DOI":"10.1074\/jbc.M400724200","article-title":"Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain","volume":"279","author":"Petrel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2016.10.008_bib36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199207093270203","article-title":"The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension","volume":"327","author":"Rich","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2016.10.008_bib37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.amjhyper.2004.10.019","article-title":"Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats","volume":"18","author":"Rybczynska","year":"2005","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2016.10.008_bib38","first-page":"533","article-title":"Pharmacological activity of calcimimetic NPS R-568 administered intravenously in rats: dose dependency","volume":"58","author":"Rybczy\u0144ska","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2016.10.008_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1677\/joe.1.06924","article-title":"Hypertensive effect of calcilytic NPS 2143 administration in rats","volume":"191","author":"Rybczynska","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib40","first-page":"163","article-title":"Blockade of calcium channels and AT1 receptor prevents the hypertensive effect of calcilytic NPS 2143 in rats","volume":"61","author":"Rybczynska","year":"2010","journal-title":"J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2016.10.008_bib41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1124\/mol.109.058784","article-title":"Agonists and allosteric modulators of the calcium-sensing receptor and their therapeutic applications","volume":"76","author":"Saidak","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib42","doi-asserted-by":"crossref","first-page":"C193","DOI":"10.1152\/ajpcell.00248.2015","article-title":"The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure","volume":"310","author":"Schepelmann","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib43","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","article-title":"Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension","volume":"111","author":"Sitbon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.10.008_bib44","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.bbrc.2006.07.192","article-title":"Extracellular calcium sensing in rat aortic vascular smooth muscle cells","volume":"348","author":"Smajilovic","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2016.10.008_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.vph.2007.06.010","article-title":"Calcimimetic, AMG 073, induces relaxation on isolated rat aorta","volume":"47","author":"Smajilovic","year":"2007","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib46","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1476-5381.2011.01317.x","article-title":"The calcium-sensing receptor and calcimimetics in blood pressure modulation","volume":"164","author":"Smajilovic","year":"2011","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ejphar.2016.10.008_bib47","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/S0140-6736(05)66782-7","article-title":"Calcimimetics and calcilytics--fooling the calcium receptor","volume":"365","author":"Steddon","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2016.10.008_bib48","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1476-5381.2010.01079.x","article-title":"Vascular actions of calcimimetics: role of Ca2(+) -sensing receptors versus Ca2(+) influx through lLs","volume":"162","author":"Thakore","year":"2011","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ejphar.2016.10.008_bib49","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/sj.bjp.0702195","article-title":"Distribution of the perivascular nerve Ca2+ receptor in rat arteries","volume":"125","author":"Wang","year":"1998","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ejphar.2016.10.008_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1476-5381.2011.01511.x","article-title":"New concepts in calcium-sensing receptor pharmacology and signalling","volume":"165","author":"Ward","year":"2012","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ejphar.2016.10.008_bib51","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.RES.0000178787.59594.a0","article-title":"Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231","volume":"97","author":"Weston","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.10.008_bib52","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/bjp.2008.108","article-title":"The expression and function of Ca(2+)-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes","volume":"154","author":"Weston","year":"2008","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ejphar.2016.10.008_bib53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00232001068","article-title":"Evidence for a calcium-sensing receptor in the vascular smooth muscle cells of the spiral modiolar artery","volume":"175","author":"Wonneberger","year":"2000","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib54","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/CIRCRESAHA.112.266361","article-title":"Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension","volume":"111","author":"Yamamura","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.10.008_bib55","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/CIRCRESAHA.113.300897","article-title":"Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells","volume":"112","author":"Yamamura","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2016.10.008_bib56","doi-asserted-by":"crossref","first-page":"e0138384","DOI":"10.1371\/journal.pone.0138384","article-title":"Inhibition of excessive cell proliferation by calcilytics in idiopathic pulmonary arterial hypertension","volume":"10","author":"Yamamura","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.10.008_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2016.04.059","article-title":"Calcilytics enhance sildenafilinduced antiproliferation in idiopathic pulmonary arterial hypertension","volume":"784","author":"Yamamura","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.10.008_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa0282","article-title":"Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma","volume":"7","author":"Yarova","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2016.10.008_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbrc.2006.01.135","article-title":"Expression of a functional extracellular calcium-sensing receptor in human aortic endothelial cells","volume":"342","author":"Ziegelstein","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916306495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916306495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T06:33:11Z","timestamp":1749623591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916306495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":59,"alternative-id":["S0014299916306495"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.10.008","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}