{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:13:52Z","timestamp":1791256432510,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ejphar.2016.11.028","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T12:31:18Z","timestamp":1479558678000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"special_numbering":"C","title":["Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice"],"prefix":"10.1016","volume":"794","author":[{"given":"Farhana","family":"Naznin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Sakoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Tsubouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M. Zaved","family":"Waise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.11.028_bib1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.clnu.2014.03.007","article-title":"Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia","volume":"33","author":"Biolo","year":"2014","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ejphar.2016.11.028_bib2","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2016.11.028_bib3","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1139\/H07-085","article-title":"Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention","volume":"32","author":"Carter","year":"2007","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.ejphar.2016.11.028_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13300-010-0006-4","article-title":"Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members","volume":"1","author":"Chen","year":"2010","journal-title":"Diabetes Ther."},{"key":"10.1016\/j.ejphar.2016.11.028_bib5","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1113\/jphysiol.2010.204594","article-title":"Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse","volume":"589","author":"Daly","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2016.11.028_bib6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/oby.2012.59","article-title":"Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats","volume":"20","author":"Devenny","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.ejphar.2016.11.028_bib7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MED.0000000000000182","article-title":"Hypothalamic inflammation and gliosis in obesity","volume":"22","author":"Dorfman","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.ejphar.2016.11.028_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00003677-200507000-00008","article-title":"Skeletal muscle lipid and its association with insulin resistance: what is the role for exercise?","volume":"33","author":"Goodpaster","year":"2005","journal-title":"Exerc. Sport Sci. Rev."},{"issue":"Spec No 2","key":"10.1016\/j.ejphar.2016.11.028_bib9","first-page":"5s20","article-title":"Insulin resistance: a contributing factor to age-related muscle mass loss?","volume":"31","author":"Guillet","year":"2005","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.ejphar.2016.11.028_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2337\/dc14-2441","article-title":"Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes","volume":"38","author":"Inzucchi","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2016.11.028_bib11","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1038\/ncomms3316","article-title":"Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization","volume":"4","author":"Izumida","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2016.11.028_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ecl.2008.09.002","article-title":"Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome","volume":"37","author":"Lara-Castro","year":"2008","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.ejphar.2016.11.028_bib13","doi-asserted-by":"crossref","first-page":"834294","DOI":"10.1155\/2014\/834294","article-title":"Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy","volume":"2014","author":"Le","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2016.11.028_bib14","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1210\/en.2014-1961","article-title":"A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice","volume":"156","author":"Lemus","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2016.11.028_bib15","doi-asserted-by":"crossref","first-page":"e30555","DOI":"10.1371\/journal.pone.0030555","article-title":"Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.11.028_bib16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2016.11.028_bib17","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3390\/ijms11041509","article-title":"Oxidative stress, molecular inflammation and sarcopenia","volume":"11","author":"Meng","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2016.11.028_bib18","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.2337\/dc15-0642","article-title":"Sodium-glucose cotransporter inhibitors: effects on renal and intestinal glucose transport: from bench to bedside","volume":"38","author":"Mudaliar","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2016.11.028_bib19","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2016.11.028_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1530\/JOE-15-0139","article-title":"Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation","volume":"226","author":"Naznin","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2016.11.028_bib21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1210\/en.2015-1588","article-title":"Tofogliflozin improves insulin resistance in skeletal muscle and accelerates lipolysis in adipose tissue in male mice","volume":"157","author":"Obata","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2016.11.028_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2016.11.028_bib23","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2337\/dc06-2537","article-title":"Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study","volume":"30","author":"Park","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2016.11.028_bib24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.clnu.2012.06.010","article-title":"Sarcopenic obesity: a critical appraisal of the current evidence","volume":"31","author":"Prado","year":"2012","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ejphar.2016.11.028_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2010.03.059","article-title":"Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure","volume":"1350","author":"Rinaman","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2016.11.028_bib26","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1038\/nutd.2014.20","article-title":"Tofogliflozin, a sodium\/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models","volume":"4","author":"Suzuki","year":"2014","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.ejphar.2016.11.028_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2016.11.028_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2014.09.025","article-title":"Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice","volume":"743","author":"Tsubouchi","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.11.028_bib29","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2337\/dc14-1630","article-title":"Weight management in type 2 diabetes: current and emerging approaches to treatment","volume":"38","author":"Van Gaal","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2016.11.028_bib30","doi-asserted-by":"crossref","first-page":"E1300","DOI":"10.1152\/ajpendo.90885.2008","article-title":"Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action","volume":"296","author":"Varma","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2016.11.028_bib31","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.bbrc.2015.07.097","article-title":"One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice","volume":"464","author":"Waise","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2016.11.028_bib32","doi-asserted-by":"crossref","first-page":"e0116851","DOI":"10.1371\/journal.pone.0116851","article-title":"Beneficial effects of canagliflozin in combination with pioglitazone on insulin sensitivity in rodent models of obese type 2 diabetes","volume":"10","author":"Watanabe","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.11.028_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2008.07.043","article-title":"Hypothalamic IKKbeta\/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity","volume":"135","author":"Zhang","year":"2008","journal-title":"Cell"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916307300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916307300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T15:51:58Z","timestamp":1568562718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916307300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":33,"alternative-id":["S0014299916307300"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.11.028","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}