{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:54:50Z","timestamp":1789851290612,"version":"4.0.1"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Poznan University of Medical Sciences Academic","award":["502-14-03305411-41169"],"award-info":[{"award-number":["502-14-03305411-41169"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.ejphar.2016.12.031","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T13:16:30Z","timestamp":1484054190000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Unknown face of known drugs \u2013 what else can we expect from angiotensin converting enzyme inhibitors?"],"prefix":"10.1016","volume":"797","author":[{"given":"Anna","family":"Wzgarda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kleszcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Prokop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Regulska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milosz","family":"Regulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Paluszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata J.","family":"Stanisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2016.12.031_bib1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1183\/09031936.00046106","article-title":"ACE I\/D but not AGT (\u22126)A\/G polymorphism is a risk factor for mortality in ARDS","volume":"29","author":"Adamzik","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1159\/000126866","article-title":"Direct regulation of hypothalamic corticotropin-releasing-hormone neurons by angiotensin-II","volume":"61","author":"Aguilera","year":"1995","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ejphar.2016.12.031_bib3","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00125-004-1474-8","article-title":"Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat","volume":"47","author":"Alderson","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2016.12.031_bib4","doi-asserted-by":"crossref","first-page":"713294","DOI":"10.1155\/2012\/713294","article-title":"Strategies to prevent anthracycline-related congestive heart failure in survivors of childhood cancer","volume":"2012","author":"Armenian","year":"2012","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.ejphar.2016.12.031_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0014-2999(79)90037-2","article-title":"Separation of human brain angiotensin-converting enzyme from enkephalin-degrading activity","volume":"59","author":"Arregui","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib6","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1471-4159.1982.tb07930.x","article-title":"Angiotensin converting enzyme in Alzheimer's disease: Increased activity in caudate nucleus and cortical areas","volume":"38","author":"Arregui","year":"1982","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejphar.2016.12.031_bib7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00246-012-0333-5","article-title":"The growing epidemic of hypertension among children and adolescents: a challenging road ahead","volume":"33","author":"Assadi","year":"2012","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1196\/annals.1414.011","article-title":"Captopril as a potential inhibitor of lung tumor growth and metastasis","volume":"1138","author":"Attoub","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1526-4610.1995.hed3508470.x","article-title":"ACE inhibitors for prophylaxis of migraine headaches","volume":"35","author":"Bender","year":"1995","journal-title":"Headache"},{"key":"10.1016\/j.ejphar.2016.12.031_bib10","first-page":"191","article-title":"Antidepressant activity of angiotensin-converting enzyme inhibitors","volume":"48","author":"Bisio","year":"1990","journal-title":"Curr. Ther. Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib11","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1161\/01.CIR.97.14.1411","article-title":"Angiotensin-converting enzyme inhibitors","volume":"97","author":"Brown","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.12.031_bib12","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1093\/eurheartj\/ehq169","article-title":"Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease","volume":"31","author":"Brugts","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/hrt.72.3.246","article-title":"Dilated cardiomyopathy in children: determinants of outcome","volume":"72","author":"Burch","year":"1994","journal-title":"Br. Heart J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00467-012-2374-7","article-title":"Additive antiproteinuric effect of enalapril and losartan in children with hemolytic uremic syndrome","volume":"28","author":"Caletti","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00467-011-1867-0","article-title":"Effect of diet, enalapril, or losartan in post-diarrheal hemolytic uremic syndrome nephropathy","volume":"26","author":"Caletti","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1210\/er.2003-0001","article-title":"Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation","volume":"24","author":"Carey","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2016.12.031_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/cei.12467","article-title":"Angiotensin II in inflammation, immunity and rheumatoid arthritis","volume":"179","author":"Chang","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.STR.0000106480.76217.6F","article-title":"Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history: the Progress Trial","volume":"35","author":"Chapman","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2016.12.031_bib19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/1470320314544163","article-title":"Lack of association between ACE insertion\/deletion polymorphism and lung cancer: a meta-analysis","volume":"16","author":"Cheng","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.phrs.2011.06.002","article-title":"Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice","volume":"64","author":"Cozzoli","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib21","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJM198606263142602","article-title":"The effects of antihypertensive therapy on the quality of life","volume":"314","author":"Croog","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2016.12.031_bib22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2125.1990.tb03810.x","article-title":"Central effects of the angiotensin-converting enzyme inhibitor, captopril. I. performance and subjective assessments of mood","volume":"30","author":"Currie","year":"1990","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib23","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/eurheartj\/ehi225","article-title":"The effect of perindopril on cardiovascular morbidity and mortality in patients with diabetes in the EUROPA study: results from the PERSUADE substudy","volume":"26","author":"Daly","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.pharmthera.2006.12.001","article-title":"ACE phenotyping as a first step toward personalized medicine for ACE inhibitors. Why does ACE genotyping not predict the therapeutic efficacy of ACE inhibition?","volume":"113","author":"Danser","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2016.12.031_bib25","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/0006-3223(86)90334-3","article-title":"Captopril treatment of depression","volume":"21","author":"Deicken","year":"1986","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ejphar.2016.12.031_bib26","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1096\/fj.11-182873","article-title":"Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease","volume":"25","author":"Dong","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib27","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/CIRCULATIONAHA.105.543470","article-title":"Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial","volume":"112","author":"Dore","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2016.12.031_bib28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jacc.2004.09.078","article-title":"Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy","volume":"45","author":"Duboc","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4238\/2013.January.22.6","article-title":"Meta-analysis demonstrates lack of association between the ACE gene I\/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity","volume":"12","author":"Feng","year":"2013","journal-title":"Genet. Mol. Res"},{"key":"10.1016\/j.ejphar.2016.12.031_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0091-3057(93)90082-5","article-title":"Angiotensin and captopril increase alcohol intake","volume":"45","author":"Fitts","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2016.12.031_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2125.1988.tb03283.x","article-title":"Psychotropic effects of repeated doses of enalapril, propanolol and atenolol in normal subjects","volume":"25","author":"Frcka","year":"1988","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nrc2945","article-title":"The renin-angiotensin system and cancer: old dog, new tricks","volume":"10","author":"George","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2016.12.031_bib33","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.envres.2011.05.020","article-title":"Captopril as a novel possible treatment for children with ADHD and elevated lead level, a hypothesis","volume":"111","author":"Ghanizadeh","year":"2011","journal-title":"Environ. Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pbb.2015.04.002","article-title":"Hypertension exacerbates predisposition to neurodegeneration and memory impairment in the presence of a neuroinflammatory stimulus: protection by angiotensin converting enzyme inhibition","volume":"133","author":"Goel","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2016.12.031_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.acvd.2012.02.010","article-title":"Three key proteases--angiotensin-I-converting enzyme (ACE), ACE2 and renin--within and beyond the renin-angiotensin system","volume":"105","author":"Guang","year":"2012","journal-title":"Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.ejphar.2016.12.031_bib36","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.7314\/APJCP.2015.16.3.1123","article-title":"Lack of influence of the ACE1 gene I\/D polymorphism on the formation and growth of benign uterine leiomyoma in Turkish patients","volume":"16","author":"G\u00fcltekin","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ejphar.2016.12.031_bib37","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/ndt\/15.10.1617","article-title":"ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus","volume":"15","author":"Ha","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ejphar.2016.12.031_bib38","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2016.12.031_bib39","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s13312-013-0262-2","article-title":"Effect of enalapril on glomerular filtration rate and proteinuria in children with chronic kidney disease: a randomized controlled trial","volume":"50","author":"Hari","year":"2013","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.ejphar.2016.12.031_bib40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/01.HYP.0000088322.85804.96","article-title":"The ACE gene I\/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition","volume":"42","author":"Harrap","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2016.12.031_bib41","first-page":"169","article-title":"No association between angiotensin I converting enzyme (ACE) I\/D polymorphism and gastric cancer risk among Japanese","volume":"73","author":"Hibi","year":"2011","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib42","first-page":"263","volume":"1978","author":"Ho","year":"1978"},{"key":"10.1016\/j.ejphar.2016.12.031_bib43","first-page":"361","article-title":"Effects of microinjection of angiotensin II and captopril into nucleus accumbens on morphine self-administration in rats","volume":"47","author":"Hosseini","year":"2009","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib44","first-page":"770","article-title":"Effects of angiotensin II and captopril on rewarding properties of morphine","volume":"45","author":"Hosseini","year":"2007","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib45","doi-asserted-by":"crossref","first-page":"15377","DOI":"10.1016\/S0021-9258(18)98626-6","article-title":"Structure of the angiotensin I-converting enzyme gene. two alternate promoters correspond to evolutionary steps of a duplicated gene","volume":"266","author":"Hubert","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2016.12.031_bib46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4331\/wjbc.v6.i3.209","article-title":"Inflammation, oxidative stress and renin angiotensin system in atherosclerosis","volume":"6","author":"Husain","year":"2015","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2016.12.031_bib47","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000319445","article-title":"Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas","volume":"32","author":"Husain","year":"2010","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/77399","article-title":"Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition","volume":"6","author":"Iwata","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2016.12.031_bib49","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neulet.2008.08.021","article-title":"Effect of angiotensin-related antihypertensives on brain neurotransmitter levels in rats","volume":"444","author":"Jenkins","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2016.12.031_bib50","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.nlm.2006.08.010","article-title":"Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats","volume":"87","author":"Jenkins","year":"2007","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ejphar.2016.12.031_bib51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0006-8993(95)00677-I","article-title":"Intrastriatal angiotensin II induces turning behaviour in 6-hydroxydopamine lesioned rats","volume":"691","author":"Jenkins","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0006-8993(96)01276-0","article-title":"Upregulation of angiotensin II AT1 receptors in the mouse nucleus accumbens by chronic haloperidol treatment","volume":"748","author":"Jenkins","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/1470320310387178","article-title":"Association of echocardiographic left ventricular structure with the ACE D\/I polymorphism: a meta-analysis","volume":"12","author":"Jin","year":"2011","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib54","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.jacc.2009.11.059","article-title":"The impact of changing medical therapy on transplantation-free survival in pediatric dilated cardiomyopathy","volume":"55","author":"Kantor","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib55","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.cjca.2013.08.008","article-title":"Presentation, diagnosis and medical management of heart failure in children: canadian cardiovascular society guidelines","volume":"29","author":"Kantor","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2350-10-50","article-title":"ACE (I\/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation","volume":"10","author":"Kitsios","year":"2009","journal-title":"BMC Med. Genet"},{"key":"10.1016\/j.ejphar.2016.12.031_bib57","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.pharep.2015.03.021","article-title":"Targeting aberrant cancer metabolism - The role of sirtuins","volume":"67","author":"Kleszcz","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2016.12.031_bib58","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/cncr.23215","article-title":"Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion\/deletion polymorphism, and cancer: the Rotterdam Study","volume":"112","author":"van der Knaap","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.ejphar.2016.12.031_bib59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1300\/J069v15n04_05","article-title":"Cocaine, dopamine and endogenous opioid system","volume":"15","author":"Kreek","year":"1996","journal-title":"J. Addict. Dis."},{"key":"10.1016\/j.ejphar.2016.12.031_bib60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/sj.jhh.1001055","article-title":"Antihypertensive treatment modulates the association between the D\/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis","volume":"14","author":"Kuznetsova","year":"2000","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.ejphar.2016.12.031_bib61","first-page":"226","article-title":"Brain angiotensin and dopaminergic degeneration:relevance to Parkinson's disease","volume":"1","author":"Labandeira-Garcia","year":"2012","journal-title":"Am. J. Neurodegener. Dis."},{"key":"10.1016\/j.ejphar.2016.12.031_bib62","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1053\/meta.2001.27212","article-title":"Angiotensin-converting enzyme gene insertion\/deletion, not bradykinin B2 receptor \u221258T\/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus","volume":"50","author":"Lee","year":"2001","journal-title":"Metabolism"},{"key":"10.1016\/j.ejphar.2016.12.031_bib63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/aje\/kwi202","article-title":"Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease","volume":"162","author":"Lehmann","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0140-6736(98)03228-0","article-title":"Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer?","volume":"352","author":"Lever","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2016.12.031_bib65","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fpsyt.2014.00083","article-title":"Stress modulates illness-course of substance use disorders: a translational review","volume":"5","author":"Lijffijt","year":"2014","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.ejphar.2016.12.031_bib66","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJM199503163321103","article-title":"A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease","volume":"332","author":"Lindpaintner","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2016.12.031_bib67","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1530-0277.1990.tb00453.x","article-title":"Angiotensin converting enzyme inhibitors reduce alcohol consumption: some possible mechanisms and important conditions for its therapeutic use","volume":"14","author":"Lingham","year":"1990","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0891988708328221","article-title":"Association of ACE I\/D gene polymorphism with vascular dementia: a meta-analysis","volume":"22","author":"Liu","year":"2009","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib69","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.oraloncology.2012.06.003","article-title":"Polymorphism of angiotensin I-converting enzyme gene is related to oral cancer and lymph node metastasis in male betel quid chewers","volume":"48","author":"Liu","year":"2012","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib70","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000328666","article-title":"Angiotensin-converting enzyme gene insertion\/deletion polymorphism in patients with chronic pancreatitis and pancreatic cancer","volume":"28","author":"Lukic","year":"2011","journal-title":"Dig. Surg."},{"key":"10.1016\/j.ejphar.2016.12.031_bib71","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00403-013-1315-z","article-title":"Association of ACE gene I\/D polymorphism with vitiligo: a meta-analysis","volume":"305","author":"Lv","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib72","doi-asserted-by":"crossref","first-page":"437","DOI":"10.5144\/0256-4947.2013.437","article-title":"Insertion\/deletion polymorphism of the ACE gene increased risk of Behcet disease: evidence from a meta-analysis","volume":"33","author":"Mandal","year":"2013","journal-title":"Ann. Saudi Med."},{"key":"10.1016\/j.ejphar.2016.12.031_bib73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0376-8716(00)00124-1","article-title":"Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy","volume":"61","author":"Margolin","year":"2000","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2016.12.031_bib74","first-page":"155","article-title":"Perindopril may improve the hippocampal reduced glutathione content in rats","volume":"4","author":"Mashhoody","year":"2014","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2016.12.031_bib75","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1096\/fj.05-3742com","article-title":"Central angiotensin II controls alcohol consumption via its AT1 receptor","volume":"19","author":"Maul","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib76","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1096\/fj.00-0797fje","article-title":"Alcohol consumption is controlled by angiotensin II","volume":"15","author":"Maul","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2016.12.031_bib77","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1073\/pnas.81.5.1575","article-title":"Autoradiographic localization of angiotensin II receptors in rat brain","volume":"81","author":"Mendelsohn","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2016.12.031_bib78","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","article-title":"Essential hypertension","volume":"370","author":"Messerli","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2016.12.031_bib79","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.clinthera.2011.09.003","article-title":"Pharmacotherapy review of chronic pediatric hypertension","volume":"33","author":"Meyers","year":"2011","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejphar.2016.12.031_bib80","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1177\/1470320315588872","article-title":"Correlation of ACE gene deletion\/insertion polymorphism and risk of pregnancy-induced hypertension: a meta-analysis based on 10,236 subjects","volume":"16","author":"Miao","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1440-1681.1983.tb00192.x","article-title":"Attenuation of the antihypertensive effect of captopril by the opioid receptor antagonist naloxone","volume":"10","author":"Millar","year":"1983","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib82","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF02244597","article-title":"Nootropic effects of ACE inhibitors in mice","volume":"100","author":"Mondadori","year":"1990","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2016.12.031_bib83","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/bjd.14653","article-title":"The angiotensin-converting enzyme gene insertion polymorphism: a higher risk for psoriasis in males","volume":"175","author":"Munir","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib84","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuropharm.2006.03.004","article-title":"Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism","volume":"51","author":"Mu\u00f1oz","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2016.12.031_bib85","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/jmg.40.12.e130","article-title":"Renoprotective efficacy of renin-angiotensin inhibitors in IgA nephropathy is influenced by ACE A2350G polymorphism","volume":"40","author":"Narita","year":"2003","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ejphar.2016.12.031_bib86","first-page":"47","article-title":"Effects of ACE-inhibitors on learning and memory processes in rats","volume":"42","author":"Nikolova","year":"2000","journal-title":"Folia Med."},{"key":"10.1016\/j.ejphar.2016.12.031_bib87","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/01.WNL.0000140705.23869.E9","article-title":"Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression","volume":"63","author":"Ohrui","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2016.12.031_bib88","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12029-015-9754-8","article-title":"Associations of the insertion\/deletion polymorphism in the ACE gene and risk of gastric cancer: a meta-analysis","volume":"46","author":"Pabalan","year":"2015","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.ejphar.2016.12.031_bib89","first-page":"392","article-title":"Arterial hypertension, renin\u2013angiotensin system and synthesis of the first angiotensin converting enzyme inhibitor \u2013 a historical review","volume":"5","author":"Paszun","year":"2008","journal-title":"J. Med. Sci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib90","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1093\/ndt\/gfl412","article-title":"Influence of ACE I\/D gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease: a meta-analysis","volume":"21","author":"Pereira","year":"2006","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.ejphar.2016.12.031_bib91","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.rbmo.2015.11.003","article-title":"Insertion\/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis","volume":"32","author":"Pereza","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ejphar.2016.12.031_bib92","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0008-6363(99)00090-5","article-title":"The ACE gene polymorphism: the good, the bad and the ugly","volume":"43","author":"Pinto","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib93","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ijo.2011.95","article-title":"Angiotensin- converting enzyme inhibition reverses diet-induced obesity, insulin resistance and infl ammation in C57BL\/6J mice","volume":"36","author":"Premaratna","year":"2012","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.ejphar.2016.12.031_bib94","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1470320310391835","article-title":"Association between ACE polymorphism and risk of IgA nephropathy: a meta-analysis","volume":"12","author":"Qin","year":"2011","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib95","first-page":"408","article-title":"Meta-analysis on the association of ACE\/ID polymorphism and essential hypertension in Chinese population","volume":"35","author":"Qu","year":"2001","journal-title":"Zhonghua Yu Fang. Yi Xue Za Zhi"},{"key":"10.1016\/j.ejphar.2016.12.031_bib96","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1054\/npep.2000.0845","article-title":"Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm","volume":"35","author":"Raghavendra","year":"2001","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2016.12.031_bib97","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/japplphysiol.00828.2011","article-title":"Epigenetic regulation of the ACE gene might be more relevant to endurance physiology than the I\/D polymorphism","volume":"112","author":"Raleigh","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib98","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2165\/00002512-200320040-00001","article-title":"The perindopril protection against recurrent stroke study (progress): clinical implications for older patients with cerebrovascular disease","volume":"20","author":"Ratnasabapathy","year":"2003","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ejphar.2016.12.031_bib99","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1445-5994.2000.tb01054.x","article-title":"The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease","volume":"30","author":"Reardon","year":"2000","journal-title":"Aust. N. Z. J. Med"},{"key":"10.1016\/j.ejphar.2016.12.031_bib100","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.2174\/13816128113199990508","article-title":"The renin-angiotensin system as a target of novel anticancer therapy","volume":"19","author":"Regulska","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2016.12.031_bib101","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.drudis.2014.06.026","article-title":"How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor","volume":"19","author":"Regulska","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2016.12.031_bib102","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/15376516.2015.1124956","article-title":"Angiotensin-converting enzyme inhibitor prevents oxidative stress, inflammation, and fibrosis in carbon tetrachloride-treated rat liver","volume":"26","author":"Reza","year":"2016","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.ejphar.2016.12.031_bib103","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2016.12.031_bib104","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1158\/1078-0432.CCR-04-1922","article-title":"The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion\/deletion polymorphism","volume":"11","author":"R\u00f6cken","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib105","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/156800911795538147","article-title":"The ACE insertion\/deletion polymorphism and risk of cancer, a review and meta-analysis of the literature","volume":"11","author":"Ruiter","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.ejphar.2016.12.031_bib106","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.intimp.2007.07.021","article-title":"Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats","volume":"8","author":"Santos","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib107","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3109\/0886022X.2016.1160247","article-title":"Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?","volume":"38","author":"Sarkar","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.ejphar.2016.12.031_bib108","first-page":"1301","article-title":"Central effects of converting enzyme inhibitors","volume":"5","author":"Sch\u00f6lkens","year":"1983","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejphar.2016.12.031_bib109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/bmj.322.7277.19","article-title":"Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study","volume":"322","author":"Schrader","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.ejphar.2016.12.031_bib110","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1017\/S136898000700064X","article-title":"Obesity, essential hypertension and renin-angiotensin system","volume":"10","author":"Segura","year":"2007","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.ejphar.2016.12.031_bib111","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11906-010-0091-9","article-title":"The evolution of renin-angiotensin blockade: angiotensin-converting enzyme inhibitors as the starting point","volume":"12","author":"Sica","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.ejphar.2016.12.031_bib112","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.4049\/jimmunol.1000314","article-title":"Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis","volume":"185","author":"da Silveira","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib113","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health study","volume":"169","author":"Sink","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ejphar.2016.12.031_bib114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.20883\/medical.e45","article-title":"The angiotensin converting enzyme inhibitors - alternative clinical applications","volume":"83","author":"Stanisz","year":"2014","journal-title":"J. Med. Sci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib115","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jacc.2004.12.023","article-title":"Did they lower stress in the trial? Or was it just wasted energy?","volume":"45","author":"Stephen","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib116","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF02239543","article-title":"Captopril in children with dilated cardiomyopathy: acute and long-term effects in a prospective study of hemodynamic and hormonal effects","volume":"11","author":"Stern","year":"1990","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib117","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1158\/1055-9965.EPI-06-0339","article-title":"Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan Cancer Epidemiol","volume":"15","author":"Sugimoto","year":"2006","journal-title":"Biomark. Prev."},{"key":"10.1016\/j.ejphar.2016.12.031_bib118","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1440-1746.2011.06964.x","article-title":"Role of renin-angiotensin system in gastric oncogenesis","volume":"27","author":"Sugimoto","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib119","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1442-200X.2012.03668.x","article-title":"Combined renin angiotensin blockade in childhood steroid-resistant nephrotic syndrome","volume":"54","author":"Supavekin","year":"2012","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.ejphar.2016.12.031_bib120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0009-8981(97)00114-9","article-title":"Characterization of chymase from human vascular tissues","volume":"265","author":"Takai","year":"1997","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2016.12.031_bib121","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1017\/S0317167100006259","article-title":"Meta-analysis of the ACE gene polymorphism in cerebral infarction","volume":"36","author":"Tao","year":"2009","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib122","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF01857634","article-title":"Angiotensin converting enzyme inhibitors: comparative structure, pharmacokinetics, and pharmacodynamics","volume":"4","author":"Thind","year":"1990","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ejphar.2016.12.031_bib123","first-page":"197","article-title":"Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels","volume":"51","author":"Tiret","year":"1992","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejphar.2016.12.031_bib124","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.numecd.2009.02.004","article-title":"Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat","volume":"20","author":"Velkoska","year":"2010","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ejphar.2016.12.031_bib125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ijnp\/pyw029","article-title":"Subjective and cardiovascular effects of intravenous methamphetamine during perindopril maintenance: a randomized, double-blind, placebo-controlled human laboratory study","volume":"19","author":"Verrico","year":"2016","journal-title":"Inter. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib126","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1517\/13543784.2013.836488","article-title":"Pharmacotherapeutics for substance-use disorders: a focus on dopaminergic medications","volume":"22","author":"Verrico","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.ejphar.2016.12.031_bib127","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2011.10.054","article-title":"Cocaine administration increases angiotensin I-converting enzyme (ACE) expression and activity in the rat striatum and frontal cortex","volume":"506","author":"Visniauskas","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2016.12.031_bib128","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejphar.2015.08.026","article-title":"Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats","volume":"765","author":"Wahba","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib129","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/00207454.2015.1025395","article-title":"Association between angiotensin-converting enzyme insertion\/deletion polymorphism and migraine: a meta-analysis","volume":"126","author":"Wan","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib130","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1442-2050.2011.01320.x","article-title":"Angiotensin-I converting enzyme inhibitors suppress angiogenesis and growth of esophageal carcinoma xenografts","volume":"25","author":"Wang","year":"2012","journal-title":"Dis. Esophagus"},{"key":"10.1016\/j.ejphar.2016.12.031_bib131","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1440-1797.2008.01008.x","article-title":"Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats","volume":"13","author":"Wiggins","year":"2008","journal-title":"Nephrology"},{"key":"10.1016\/j.ejphar.2016.12.031_bib132","first-page":"860923","article-title":"Importance of the brain angiotensin system in parkinson's disease","volume":"2012","author":"Wright","year":"2012","journal-title":"Park. Dis."},{"key":"10.1016\/j.ejphar.2016.12.031_bib133","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1081\/CEH-120024988","article-title":"Age-related decline in spatial learning and memory: attenuation by captopril","volume":"25","author":"Wyss","year":"2003","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejphar.2016.12.031_bib134","first-page":"1073","article-title":"The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: possible role of the vascular endothelial growth factor","volume":"7","author":"Yoshiji","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2016.12.031_bib135","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1440-1797.2012.01592.x","article-title":"Meta-analysis of the relationship between ACE I\/D gene polymorphism and end-stage renal disease in patients with diabetic nephropathy","volume":"17","author":"Yu","year":"2012","journal-title":"Nephrol. (Carlton)"},{"key":"10.1016\/j.ejphar.2016.12.031_bib136","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-2007-1003665","article-title":"The effect of angiotensin-converting enzyme inhibition on ACTH response to corticotropin-releasing hormone (CRH) in normal men","volume":"23","author":"Zacharieva","year":"1991","journal-title":"Horm. Metab. Res"},{"key":"10.1016\/j.ejphar.2016.12.031_bib137","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/1470320314539829","article-title":"Relationship between polymorphism of angiotensin-converting enzyme gene insertion\/deletion and risk of hepatocellular carcinoma in a Chinese Dai population","volume":"16","author":"Zha","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib138","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00467-015-3184-5","article-title":"Long-term treatment by ACE inhibitors and angiotensin receptor blockers in children with Alport syndrome","volume":"31","author":"Zhang","year":"2016","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ejphar.2016.12.031_bib139","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2014.07.023","article-title":"Association between the ACE I\/D polymorphism and risk of ischemic stroke: an updated meta-analysis of 47,026 subjects from 105 case-control studies","volume":"345","author":"Zhao","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejphar.2016.12.031_bib140","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2337\/db07-1524","article-title":"Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor\u2013to\u2013pigment epithelium\u2013derived factor ratio","volume":"58","author":"Zheng","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2016.12.031_bib141","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/1470320311434242","article-title":"Meta-analysis of the association between the insertion\/deletion polymorphism in ACE gene and coronary heart disease among the Chinese population","volume":"13","author":"Zhou","year":"2012","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib142","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/1470320312437892","article-title":"Association of ACE I\/D gene polymorphism with vesicoureteral reflux susceptibility in children: a meta-analysis","volume":"13","author":"Zhou","year":"2012","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2016.12.031_bib143","doi-asserted-by":"crossref","first-page":"e19599","DOI":"10.1371\/journal.pone.0019599","article-title":"ACE I\/D gene polymorphism can't predict the steroid responsiveness in Asian children with idiopathic nephrotic syndrome: a meta-analysis","volume":"6","author":"Zhou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2016.12.031_bib144","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/08039488.2011.555564","article-title":"Meta-analysis of ACE gene I\/D polymorphism and bipolar disorder susceptibility","volume":"65","author":"Zou","year":"2011","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2016.12.031_bib145","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1176\/ajp.141.1.110","article-title":"Mood-elevation effect of captopril in depressed patients","volume":"141","author":"Zubenko","year":"1984","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2016.12.031_bib146","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2016.02.026","article-title":"Renin-angiotensin system gene polymorphisms as risk factors for multiple sclerosis","volume":"363","author":"\u017divkovi\u0107","year":"2016","journal-title":"J. Neurol. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916308111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299916308111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:55:47Z","timestamp":1658364947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299916308111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":146,"alternative-id":["S0014299916308111"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.12.031","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unknown face of known drugs \u2013 what else can we expect from angiotensin converting enzyme inhibitors?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2016.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}