{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:44:37Z","timestamp":1769503477546,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Thailand Research Fund and Mahidol University","award":["BRG5980008"],"award-info":[{"award-number":["BRG5980008"]}]},{"name":"Thailand Research Fund and Mahidol University","award":["PHD\/0105\/2556"],"award-info":[{"award-number":["PHD\/0105\/2556"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.ejphar.2017.01.026","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T17:16:00Z","timestamp":1485018960000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-\u03baB inhibition and AMPK activation"],"prefix":"10.1016","volume":"798","author":[{"given":"Pawin","family":"Pongkorpsakol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saravut","family":"Satitsri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preedajit","family":"Wongkrasant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamorn","family":"Chittavanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suticha","family":"Kittayaruksakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Potjanee","family":"Srimanote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varanuj","family":"Chatsudthipong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchai","family":"Muanprasat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.01.026_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1124\/jpet.111.183020","article-title":"Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase","volume":"339","author":"Chi","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2017.01.026_bib2","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/jcc.21478","article-title":"A new Lamarckian genetic algorithm for flexible ligand-receptor docking","volume":"31","author":"Fuhrmann","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejphar.2017.01.026_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pharmthera.2013.01.012","article-title":"Flufenamic acid as an ion channel modulator","volume":"138","author":"Guinamard","year":"2013","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.ejphar.2017.01.026_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0022-3565(25)32928-9","article-title":"Laxative-like effects of nonsteroidal anti-inflammatory drugs on intestinal fluid movement and membrane integrity","volume":"220","author":"Gullikson","year":"1982","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.ejphar.2017.01.026_bib5","first-page":"251","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis. nature reviews","volume":"13","author":"Hardie","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2017.01.026_bib6","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4269\/ajtmh.2008.79.708","article-title":"Shifting prevalence of major diarrheal pathogens in patients seeking hospital care during floods in 1998, 2004, and 2007 in Dhaka, Bangladesh","volume":"79","author":"Harris","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejphar.2017.01.026_bib7","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/S0140-6736(12)60436-X","volume":"379","author":"Harris","year":"2012","journal-title":"Cholera Lancet"},{"key":"10.1016\/j.ejphar.2017.01.026_bib8","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.4049\/jimmunol.159.11.5550","article-title":"Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells","volume":"159","author":"Hobbie","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2017.01.026_bib9","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1074\/jbc.M806780200","article-title":"Mechanistic insight into control of CFTR by AMPK","volume":"284","author":"Kongsuphol","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.01.026_bib10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1124\/mol.114.095810","article-title":"Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation","volume":"87","author":"Krishan","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejphar.2017.01.026_bib11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4155\/fmc.13.42","article-title":"Cholera: pathophysiology and emerging therapeutic targets","volume":"5","author":"Muanprasat","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejphar.2017.01.026_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bcp.2015.05.016","article-title":"Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: mechanism of action and potential applications in intestinal disorders","volume":"96","author":"Muanprasat","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2017.01.026_bib13","first-page":"387","article-title":"Hybrid & El Tor variant biotypes of Vibrio cholerae O1 in Thailand","volume":"133","author":"Na-Ubol","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.ejphar.2017.01.026_bib14","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1128\/JCM.40.9.3296-3299.2002","article-title":"New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh","volume":"40","author":"Nair","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ejphar.2017.01.026_bib15","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4049\/jimmunol.165.2.903","article-title":"Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells","volume":"165","author":"Philpott","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2017.01.026_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00109-011-0748-0","article-title":"AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan","volume":"89","author":"Salminen","year":"2011","journal-title":"J. Mol. Med (Berl.)"},{"issue":"7","key":"10.1016\/j.ejphar.2017.01.026_bib17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/21505594.2016.1192743","article-title":"Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice","volume":"7","author":"Satitsri","year":"2016","journal-title":"Virulence"},{"key":"10.1016\/j.ejphar.2017.01.026_bib18","doi-asserted-by":"crossref","first-page":"e2293","DOI":"10.1371\/journal.pntd.0002293","article-title":"An adult mouse model of -induced Diarrhea for studying pathogenesis and potential therapy of cholera","volume":"7","author":"Sawasvirojwong","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ejphar.2017.01.026_bib19","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.4269\/ajtmh.2006.74.1067","article-title":"Diarrheal epidemics in Dhaka, Bangladesh, during three consecutive floods: 1988, 1998, and 2004","volume":"74","author":"Schwartz","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejphar.2017.01.026_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0950268809990550","article-title":"El Tor cholera with severe disease: a new threat to Asia and beyond","volume":"138","author":"Siddique","year":"2010","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.ejphar.2017.01.026_bib21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2353\/ajpath.2010.090548","article-title":"Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation","volume":"176","author":"Tang","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2017.01.026_bib22","doi-asserted-by":"crossref","first-page":"17272","DOI":"10.1073\/pnas.0608531103","article-title":"AMP-activated protein kinase regulates the assembly of epithelial tight junctions","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917300341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917300341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T18:20:29Z","timestamp":1749925229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917300341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":22,"alternative-id":["S0014299917300341"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.01.026","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-\u03baB inhibition and AMPK activation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}