{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:31:28Z","timestamp":1778682688224,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.ejphar.2017.01.041","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T19:31:53Z","timestamp":1486150313000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits"],"prefix":"10.1016","volume":"798","author":[{"given":"Yuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Wu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Ping","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Min","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.01.041_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCULATIONAHA.110.985150","article-title":"Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling","volume":"124","author":"Antoniades","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib2","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1161\/01.CIR.98.18.1842","article-title":"Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia","volume":"98","author":"Boger","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00005344-199203000-00005","article-title":"Antioxidant effects of angiotensin-converting enzyme (ACE) inhibitors: free radical and oxidant scavenging are sulfhydryl dependent, but lipid peroxidation is inhibited by both sulfhydryl- and nonsulfhydryl-containing ACE inhibitors","volume":"19","author":"Chopra","year":"1992","journal-title":"J. Cardiovasc Pharm."},{"key":"10.1016\/j.ejphar.2017.01.041_bib4","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/01.CIR.0000126823.07732.D5","article-title":"Asymmetrical dimethylarginine: the Uber marker?","volume":"109","author":"Cooke","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1358863X10362605","article-title":"DDAH: a target for vascular therapy?","volume":"15","author":"Cooke","year":"2010","journal-title":"Vasc. Med."},{"key":"10.1016\/j.ejphar.2017.01.041_bib6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/01.CIR.95.2.311","article-title":"Arginine: a new therapy for atherosclerosis?","volume":"95","author":"Cooke","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib7","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1161\/01.ATV.20.9.2039","article-title":"Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes","volume":"20","author":"Fard","year":"2000","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2008.01.029","article-title":"Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH\/ADMA\/NOS\/NO pathway in endothelial cells induced by lysophosphatidylcholine","volume":"584","author":"Feng","year":"2008","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.ejphar.2017.01.041_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijcard.2010.04.019","article-title":"Improvement of endothelial dysfunction in atherosclerotic rabbit aortas by ex vivo gene transferring of dimethylarginine dimethylaminohydrolase-2","volume":"144","author":"Feng","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2004.11.063","article-title":"A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats","volume":"508","author":"Fu","year":"2005","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.ejphar.2017.01.041_bib11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopha.2009.02.006","article-title":"Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation","volume":"63","author":"Fukuda","year":"2009","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.ejphar.2017.01.041_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02789331","article-title":"Methods for construction of adenovirus vectors","volume":"3","author":"Graham","year":"1995","journal-title":"Mol.. Biotechnol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib13","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/01.CIR.99.24.3092","article-title":"Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase","volume":"99","author":"Ito","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib14","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.2353\/ajpath.2010.090614","article-title":"Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine","volume":"176","author":"Jacobi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib15","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.bjp.0704563","article-title":"Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level","volume":"135","author":"Jiang","year":"2002","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ejphar.2017.01.041_bib16","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Jr Gimbrone","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2017.01.041_bib17","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.ATV.0000125114.88079.96","article-title":"Dysfunction of endothelial nitric oxide synthase and atherosclerosis","volume":"24","author":"Kawashima","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ijcard.2007.08.066","article-title":"Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus","volume":"132","author":"Kawata","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.atherosclerosis.2009.09.007","article-title":"Combination therapy for treatment or prevention of atherosclerosis: focus on the lipid-RAAS interaction","volume":"209","author":"Koh","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2017.01.041_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1253\/circj.CJ-13-1494","article-title":"Statins and renin-angiotensin system inhibitor combination treatment to prevent cardiovascular disease","volume":"78","author":"Lee","year":"2014","journal-title":"Circ. J."},{"key":"10.1016\/j.ejphar.2017.01.041_bib21","doi-asserted-by":"crossref","first-page":"13527","DOI":"10.1073\/pnas.212269799","article-title":"S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase","volume":"99","author":"Leiper","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.01.041_bib22","doi-asserted-by":"crossref","first-page":"e111529","DOI":"10.1371\/journal.pone.0111529","article-title":"A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit","volume":"9","author":"Liaw","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.01.041_bib23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.0000027109.14149.67","article-title":"Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase","volume":"106","author":"Lin","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib24","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1128\/JVI.70.11.7498-7509.1996","article-title":"Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy","volume":"70","author":"Mittereder","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.ejphar.2017.01.041_bib25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.CIR.99.9.1141","article-title":"Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis","volume":"99","author":"Miyazaki","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2017.01.041_bib26","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ahj.2008.09.006","article-title":"Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide\/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension","volume":"156","author":"Napoli","year":"2008","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejphar.2017.01.041_bib27","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1056\/NEJM198909283211305","article-title":"A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension","volume":"321","author":"Pollare","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2017.01.041_bib28","doi-asserted-by":"crossref","first-page":"35338","DOI":"10.1074\/jbc.M109.037036","article-title":"Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production","volume":"284","author":"Pope","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"Suppl 12","key":"10.1016\/j.ejphar.2017.01.041_bib29","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1097\/00005344-199204002-00018","article-title":"Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis","volume":"20","author":"Vallance","year":"1992","journal-title":"J. Cardiovasc. Pharm."},{"key":"10.1016\/j.ejphar.2017.01.041_bib30","first-page":"11","article-title":"Cryotherapy increases features of plaque stability in atherosclerotic rabbits","author":"Verheye","year":"2015","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ejphar.2017.01.041_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.atherosclerosis.2006.02.003","article-title":"Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: effects of aminoguanidine","volume":"190","author":"Yin","year":"2007","journal-title":"Atherosclerosis"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917300511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917300511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T15:36:49Z","timestamp":1601566609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917300511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":31,"alternative-id":["S0014299917300511"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.01.041","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.01.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}