{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:56:31Z","timestamp":1780520191910,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.ejphar.2017.03.023","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T19:46:42Z","timestamp":1489693602000},"page":"148-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions"],"prefix":"10.1016","volume":"803","author":[{"given":"Saravana Babu","family":"Chidambaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranju","family":"Vijayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathiya","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugumar","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barathidsan","family":"Rajamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishnan","family":"Ganapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.03.023_bib1","doi-asserted-by":"publisher","first-page":"R57","DOI":"10.1097\/00001756-199808030-00001","article-title":"3-Nitropropionic acid's lethal triplet: cooperative pathways of neurodegeneration","volume":"9","author":"Alexi","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2017.03.023_bib2","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1080\/10826070701588760","article-title":"Development and validation of an HPTLC method for simultaneous estimation of excitatory neurotransmitters in rat brain","volume":"30","author":"Babu","year":"2007","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.ejphar.2017.03.023_bib3","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.ejphar.2017.03.023_bib4","doi-asserted-by":"publisher","first-page":"E228","DOI":"10.1038\/cddis.2011.112","article-title":"Neurodegenerative processes in Huntington's disease","volume":"2","author":"Bano","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2017.03.023_bib5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4103\/2152-7806.83391","article-title":"Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy- a unifying hypothesis","volume":"2","author":"Blaylock","year":"2011","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.ejphar.2017.03.023_bib6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0006-8993(96)00916-X","article-title":"Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats","volume":"741","author":"Block","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2017.03.023_bib7","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1042\/BST0351127","article-title":"Chronic microglial activation and progressive dopaminergic neurotoxicity","volume":"35","author":"Block","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2017.03.023_bib8","first-page":"268","volume":"viii","author":"Bregman","year":"1987"},{"key":"10.1016\/j.ejphar.2017.03.023_bib9","doi-asserted-by":"publisher","first-page":"e0134482","DOI":"10.1371\/journal.pone.0134482","article-title":"PARP-1 Inhibition is Neuroprotective in the R6\/2 Mouse Model of Huntington's Disease","volume":"10","author":"Cardinale","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.03.023_bib10","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0014-4886(03)00367-4","article-title":"I. 3- Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice","volume":"184","author":"Couturier","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2017.03.023_bib11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1742-2094-9-31","article-title":"Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor","volume":"9","author":"D\u2019Avila","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2017.03.023_bib12","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.neuroscience.2007.03.024","article-title":"Exacerbation of excitotoxic neuronal death induced during mitochondrial inhibition in vivo: relation to energy imbalance or ATP depletion?","volume":"146","author":"Del Rio","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2017.03.023_bib13","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1111\/j.1460-9568.2012.08116.x","article-title":"Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance","volume":"36","author":"Gerace","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2017.03.023_bib14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2017.03.023_bib15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1741-7007-10-7","article-title":"A novel role for microglia in minimizing excitotoxicity","volume":"10","author":"Howe","year":"2012","journal-title":"BMC Biol."},{"key":"10.1016\/j.ejphar.2017.03.023_bib16","first-page":"321","article-title":"Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor","volume":"47","author":"Jacewicz","year":"2009","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.ejphar.2017.03.023_bib17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbi.2014.01.015","article-title":"Ethyl pyruvate ameliorates 3-nitropropionic acid- induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms","volume":"38","author":"Jang","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2017.03.023_bib18","doi-asserted-by":"publisher","first-page":"20026","DOI":"10.1074\/jbc.M109218200","article-title":"Macrophage\/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway","volume":"277","author":"Kanazawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.03.023_bib19","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.brainres.2009.09.103","article-title":"Vertical grid test and modifiedhorizontal grid test are sensitive methods for evaluating motor dysfunctionsin the MPTP mouse model of Parkinson's disease","volume":"1306","author":"Kim","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2017.03.023_bib20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.brainres.2006.08.035","article-title":"Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease","volume":"1118","author":"Lee","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2017.03.023_bib21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1602\/neurorx.1.1.101","article-title":"Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults","volume":"1","author":"Lipton","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.ejphar.2017.03.023_bib22","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/nn1988","article-title":"Glial cells as intrinsic components of non-cell- autonomous neurodegenerative disease","volume":"10","author":"Lobsiger","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2017.03.023_bib23","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation & chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2017.03.023_bib24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2047-9158-1-9","article-title":"The changing phenotype of microglia from homeostasis to disease","volume":"1","author":"Luo","year":"2012","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ejphar.2017.03.023_bib25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/ncpneuro0355","article-title":"Mechanisms of disease: astrocytes in neurodegenerative disease","volume":"2","author":"Maragakis","year":"2006","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2017.03.023_bib26","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1523\/JNEUROSCI.22-11-04478.2002","article-title":"Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration","volume":"22","author":"Mittoux","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2017.03.023_bib27","doi-asserted-by":"publisher","first-page":"4446","DOI":"10.1093\/emboj\/18.16.4446","article-title":"Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice","volume":"18","author":"Oliver","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2017.03.023_bib28","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3346\/jkms.2003.18.6.869","article-title":"Effects of dopamine infusion on cerebral blood flow, brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet","volume":"18","author":"Park","year":"2003","journal-title":"J. Korean Med Sci."},{"key":"10.1016\/j.ejphar.2017.03.023_bib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2014.11.036","article-title":"Memantine exerts functional recovery by improving BDNF and GDNF expression in 3-nitropropionic acid intoxicated mice","volume":"586","author":"Ranju","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2017.03.023_bib30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neuropharm.2013.05.025","article-title":"Telmisartan attenuates MPTP induced dopaminergic degeneration and motordysfunction through regulation of alpha-synuclein and neurotrophic factors(BDNF and GDNF) expression in C57BL\/6J mice","volume":"73","author":"Sathiya","year":"2013","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.ejphar.2017.03.023_bib31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative disease","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2017.03.023_bib32","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jneumeth.2006.07.027","article-title":"Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection","volume":"159","author":"Stephenson","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2017.03.023_bib33","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3390\/molecules15020878","article-title":"3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future","volume":"15","author":"Tunez","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2017.03.023_bib34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1742-2094-9-27","article-title":"Neuroprotective function for ramified microglia in hippocampal excitotoxicity","volume":"9","author":"Vinet","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejphar.2017.03.023_bib35","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1038\/npp.2009.64","article-title":"Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation","volume":"34","author":"Wu","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2017.03.023_bib36","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1046\/j.1471-4159.1994.63051772.x","article-title":"3-Nitropropionic acid toxicity in the striatum","volume":"63","author":"W\u00fcllner","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2017.03.023_bib37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neulet.2011.07.055","article-title":"Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression","volume":"503","author":"Ye","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2017.03.023_bib38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington's disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917301929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917301929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T17:24:18Z","timestamp":1568913858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917301929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":38,"alternative-id":["S0014299917301929"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.03.023","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}