{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:18:32Z","timestamp":1774725512615,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"crossref","award":["52\/8\/2012\/BMS"],"award-info":[{"award-number":["52\/8\/2012\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ejphar.2017.07.042","type":"journal-article","created":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T01:01:35Z","timestamp":1500771695000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Valporic acid enhances the Atrial Natriuretic Peptide (ANP) mediated anti-hypertrophic activity by modulating the Npr1 gene transcription in H9c2 cells in vitro"],"prefix":"10.1016","volume":"813","author":[{"given":"Senthamizharasi","family":"Manivasagam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamilselvi","family":"Velusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boopathi","family":"Sowndharajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navvi","family":"Chandrasekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Dhanusu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elangovan","family":"Vellaichamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"31","key":"10.1016\/j.ejphar.2017.07.042_bib1","doi-asserted-by":"crossref","first-page":"28930","DOI":"10.1074\/jbc.M303113200","article-title":"Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors","volume":"278","author":"Antos","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbrc.2006.08.003","article-title":"Inhibition and down-regulation of gene transcription and guanylyl cyclase activity of NPRA by angiotensin II involving protein kinase C","volume":"349","author":"Arise","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1517\/14740338.7.1.53","article-title":"Histone deacetylase inhibition in the treatment of heart disease","volume":"7","author":"Berry","year":"2008","journal-title":"Expert Opin. Drug Saf."},{"issue":"6","key":"10.1016\/j.ejphar.2017.07.042_bib4","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1073\/pnas.88.6.2132","article-title":"Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy","volume":"88","author":"Bishopric","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.ejphar.2017.07.042_bib5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.2042-7158.2012.01475.x","article-title":"Epigenetics of psychoactive drugs","volume":"64","author":"Boyadjieva","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2017.07.042_bib6","doi-asserted-by":"crossref","first-page":"H707","DOI":"10.1152\/ajpheart.00677.2001","article-title":"Ventricular expression of natriuretic peptides inNpr1\u2212\/\u2212 mice with cardiac hypertrophy and fibrosis","volume":"283","author":"Ellmers","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib7","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.5.1.1","article-title":"Guanylyl cyclase receptors","volume":"5","author":"Garbers","year":"1994","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.ejphar.2017.07.042_bib8","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/cdd.2009.216","article-title":"HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP\/p300 and P\/CAF-dependent p53 acetylation","volume":"17","author":"Gaub","year":"2010","journal-title":"Cell. Death Differ."},{"issue":"8","key":"10.1016\/j.ejphar.2017.07.042_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1139\/y11-040","article-title":"Atrial natriuretic peptides in heart failure: pathophysiological significance, diagnostic and prognostic value","volume":"89","author":"Ghosh","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib10","first-page":"48","article-title":"Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts","volume":"51","author":"Gopi","year":"2013","journal-title":"Indian J. Exp. Biol."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2017.07.042_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11010-015-2513-0","article-title":"Angiotensin II down-regulates natriuretic peptide receptor-A expression and guanylyl cyclase activity in H9c2 (2-1) cardiac myoblast cells: role of ROS and NF-\u03baB","volume":"409","author":"Gopi","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jmb.2004.02.006","article-title":"Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis","volume":"338","author":"Gregoretti","year":"2004","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.ejphar.2017.07.042_bib13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1367-5931(97)80066-X","article-title":"Nuclear histone acetylases and deacetylases and transcriptional regulation: hats off to HDACs","volume":"1","author":"Hassig","year":"1997","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"9","key":"10.1016\/j.ejphar.2017.07.042_bib14","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI17061","article-title":"Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A","volume":"111","author":"Holtwick","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2017.07.042_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2017.01.026","article-title":"Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists","author":"Iwaki","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.ejphar.2017.07.042_bib16","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1476-5381.2010.00637.x","article-title":"Antifibrotic activity of an inhibitor of histone deacetylases in DOCA\u2010salt hypertensive rats","volume":"159","author":"Iyer","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejphar.2017.07.042_bib17","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/eurheartj\/ehn206","article-title":"Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction","volume":"29","author":"Kasama","year":"2008","journal-title":"Eur. Heart J."},{"issue":"22","key":"10.1016\/j.ejphar.2017.07.042_bib18","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/CIRCULATIONAHA.106.625467","article-title":"Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy","volume":"113","author":"Kong","year":"2006","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ejphar.2017.07.042_bib19","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1172\/JCI19137","article-title":"Cardiac hypertrophy and histone deacetylase\u2013dependent transcriptional repression mediated by the atypical homeodomain protein Hop","volume":"112","author":"Kook","year":"2003","journal-title":"J. Clin. Invest"},{"issue":"48","key":"10.1016\/j.ejphar.2017.07.042_bib20","doi-asserted-by":"crossref","first-page":"37521","DOI":"10.1074\/jbc.M110.132795","article-title":"Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase\/atrial natriuretic peptide receptor-A gene transcription","volume":"285","author":"Kumar","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.ejphar.2017.07.042_bib21","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1124\/mol.114.092221","article-title":"All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: role of histone modification","volume":"85","author":"Kumar","year":"2014","journal-title":"Mol. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2017.07.042_bib22","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1074\/jbc.M113.511444","article-title":"Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase\/natriuretic peptide receptor-a gene interactive roles of modified histones, histone acetyltransferase, p300, and Sp1","volume":"289","author":"Kumar","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib23","doi-asserted-by":"crossref","first-page":"H33","DOI":"10.1152\/ajpheart.2000.278.1.H33","article-title":"Effects of natriuretic peptides on load and myocardial function in normal and heart failure dogs","volume":"278","author":"Lainchbury","year":"2000","journal-title":"Am. J. Physiol. Heart Circ."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2310\/JIM.0b013e3181946fb2","article-title":"Designer natriuretic peptides","volume":"57","author":"Lee","year":"2009","journal-title":"J. Investig. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2017.07.042_bib25","doi-asserted-by":"crossref","first-page":"H968","DOI":"10.1152\/ajpheart.00891.2006","article-title":"Inhibition of histone deacetylase on ventricular remodeling in infarcted rats","volume":"293","author":"Lee","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.ejphar.2017.07.042_bib26","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.yjmcc.2008.08.015","article-title":"Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin","volume":"45","author":"Liu","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.ejphar.2017.07.042_bib27","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.yjmcc.2008.08.015","article-title":"Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin","volume":"45","author":"Liu","year":"2008","journal-title":"J. Mol. Cell Cardiol."},{"issue":"37","key":"10.1016\/j.ejphar.2017.07.042_bib28","doi-asserted-by":"crossref","first-page":"23064","DOI":"10.1074\/jbc.272.37.23064","article-title":"The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling","volume":"272","author":"Lopez","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2017.07.042_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mce.2016.06.010","article-title":"Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during \u03b2-adrenergic receptor activation-induced hypertrophic growth in rats","volume":"433","author":"Manivasagam","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2017.07.042_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pharmtox-010611-134712","article-title":"Therapeutic potential for HDAC inhibitors in the heart","volume":"52","author":"McKinsey","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.ejphar.2017.07.042_bib31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4149\/gpb_2012_015","article-title":"Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol","volume":"31","author":"Nichtova","year":"2012","journal-title":"Gen. Physiol. Biophys."},{"issue":"3","key":"10.1016\/j.ejphar.2017.07.042_bib32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbrc.2008.11.057","article-title":"An HDAC inhibitor, trichostatin A, induces a delay at G 2\/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner","volume":"378","author":"Noh","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"26","key":"10.1016\/j.ejphar.2017.07.042_bib33","doi-asserted-by":"crossref","first-page":"14730","DOI":"10.1073\/pnas.94.26.14730","article-title":"Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A","volume":"94","author":"Oliver","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2017.07.042_bib34","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1073\/pnas.95.5.2547","article-title":"Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner","volume":"95","author":"Oliver","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2017.07.042_bib35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.peptides.2004.09.024","article-title":"Biology of natriuretic peptides and their receptors","volume":"26","author":"Pandey","year":"2005","journal-title":"Peptides"},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2017.07.042_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11010-013-1612-z","article-title":"Suppression of atrial natriuretic peptide\/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts","volume":"378","author":"Parthasarathy","year":"2013","journal-title":"Mol. Cell. Biochem"},{"issue":"39","key":"10.1016\/j.ejphar.2017.07.042_bib37","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1210\/er.2005-0014","article-title":"Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions","volume":"27","author":"Potter","year":"2006","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.ejphar.2017.07.042_bib39","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jacc.2005.12.081","article-title":"Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension","volume":"48","author":"Rubattu","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.ejphar.2017.07.042_bib40","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.bbadis.2009.09.009","article-title":"Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development","volume":"1792","author":"Scott","year":"2009","journal-title":"Biochim. Et. Biophys. Acta Bba. Mol. Basis Dis."},{"issue":"3","key":"10.1016\/j.ejphar.2017.07.042_bib41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.HYP.16.3.301","article-title":"Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes","volume":"16","author":"Steinhelper","year":"1990","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.ejphar.2017.07.042_bib42","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1172\/JCI117757","article-title":"A functional role for endogenous atrial natriuretic peptide in a canine model of early left ventricular dysfunction","volume":"95","author":"Stevens","year":"1995","journal-title":"J. Clin. Investig."},{"issue":"7","key":"10.1016\/j.ejphar.2017.07.042_bib43","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1152\/physiolgenomics.00073.2015","article-title":"Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice","volume":"48","author":"Subramanian","year":"2016","journal-title":"Physiol. Genom."},{"issue":"3","key":"10.1016\/j.ejphar.2017.07.042_bib44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1253\/circj.69.283","article-title":"Multicenter prospective investigation on efficacy and safety of carperitide for acute heart failure in thereal world'of therapy","volume":"69","author":"Suwa","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/01.CIR.87.1.70","article-title":"Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure","volume":"87","author":"Tsutamoto","year":"1993","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ejphar.2017.07.042_bib46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbrc.2004.11.153","article-title":"Reduced cGMP signaling activates NF-\u03baB in hypertrophied hearts of mice lacking natriuretic peptide receptor-A","volume":"327","author":"Vellaichamy","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.ejphar.2017.07.042_bib47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physiolgenomics.00079.2007","article-title":"Genetic disruption of guanylyl cyclase\/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy","volume":"31","author":"Vellaichamy","year":"2007","journal-title":"Physiol. Genom."},{"issue":"37","key":"10.1016\/j.ejphar.2017.07.042_bib48","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","article-title":"HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention","volume":"26","author":"Yang","year":"2007","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.ejphar.2017.07.042_bib49","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/01.CIR.87.2.464","article-title":"Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure","volume":"87","author":"Yoshimura","year":"1993","journal-title":"Circulation"},{"issue":"48","key":"10.1016\/j.ejphar.2017.07.042_bib50","doi-asserted-by":"crossref","first-page":"47694","DOI":"10.1074\/jbc.M309661200","article-title":"Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse hearts","volume":"278","author":"Zahabi","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"11\u201312","key":"10.1016\/j.ejphar.2017.07.042_bib51","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s001090050176","article-title":"Catecholamine-induced cardiac hypertrophy: significance of proto-oncogene expression","volume":"75","author":"Zimmer","year":"1997","journal-title":"J. Mol. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917304971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917304971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T12:04:39Z","timestamp":1569931479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917304971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":51,"alternative-id":["S0014299917304971"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.07.042","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valporic acid enhances the Atrial Natriuretic Peptide (ANP) mediated anti-hypertrophic activity by modulating the Npr1 gene transcription in H9c2 cells in vitro","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.07.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}