{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:15:04Z","timestamp":1791900904034,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Health, Labor and Welfare","award":["H26-itaku(nan)-ippan-059"],"award-info":[{"award-number":["H26-itaku(nan)-ippan-059"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ejphar.2017.08.005","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T09:33:09Z","timestamp":1503048789000},"page":"161-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells-derived disease model"],"prefix":"10.1016","volume":"814","author":[{"given":"Shiori","family":"Ando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Funato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Ohuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsubasa","family":"Kameyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuru","family":"Kawase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tsuruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2017.08.005_bib1","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/jnr.22106","article-title":"Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy","volume":"87","author":"Acsadi","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2017.08.005_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative stress and Parkinson's disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.ejphar.2017.08.005_bib3","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/hmg\/ddg256","article-title":"Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy","volume":"12","author":"Brichta","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.08.005_bib4","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/hmg\/6.8.1205","article-title":"The survival motor neuron protein in spinal muscular atrophy","volume":"6","author":"Coovert","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.08.005_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nbdi.1996.0010","article-title":"The neurobiology of childhood spinal muscular atrophy","volume":"3","author":"Crawford","year":"1996","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2017.08.005_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2017.08.005_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3164\/jcbn.16-34","article-title":"Reactive oxygen species induce neurite degeneration before induction of cell death","volume":"59","author":"Fukui","year":"2016","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.ejphar.2017.08.005_bib8","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1093\/hmg\/4.10.1927","article-title":"Molecular analysis of candidate genes on chromosome 5q13 in autosomal recessive spinal muscular atrophy: evidence of homozygous deletions of the SMN gene in unaffected individuals","volume":"4","author":"Hahnen","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.08.005_bib9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0387-7604(02)00103-1","article-title":"Oxidative stress and disturbed glutamate transport in spinal muscular atrophy","volume":"24","author":"Hayashi","year":"2002","journal-title":"Brain Dev."},{"key":"10.1016\/j.ejphar.2017.08.005_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.scr.2015.09.006","article-title":"Amyotrophic lateral sclerosis models derived from human embryonic stem cells with different superoxide dismutase 1 mutations exhibit differential drug responses","volume":"15","author":"Isobe","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.ejphar.2017.08.005_bib11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.expneurol.2008.07.017","article-title":"Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice","volume":"213","author":"Ito","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2017.08.005_bib12","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1093\/hmg\/ddq425","article-title":"A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2","volume":"19","author":"Jodelka","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.08.005_bib13","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1096\/fj.06-7859rev","article-title":"Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival","volume":"22","author":"Junttila","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2017.08.005_bib14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/hmg\/ddi130","article-title":"The role of histone acetylation in SMN gene expression","volume":"14","author":"Kernochan","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2017.08.005_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The role of oxidative stress inNeurodegenerative diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.ejphar.2017.08.005_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2017.08.005_bib17","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"Lorson","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2017.08.005_bib18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2017.08.005_bib19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.stem.2015.08.003","article-title":"Genome-wide RNA-Seq of human motor neurons implicates selective ER stress activation in spinal muscular atrophy","volume":"17","author":"Ng","year":"2015","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.ejphar.2017.08.005_bib20","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/01.STR.20.9.1236","article-title":"Effect of MCI-186 on brain edema in rats","volume":"20","author":"Nishi","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2017.08.005_bib21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5966\/sctm.2015-0059","article-title":"Established stem cell model of spinal muscular atrophy is applicable in the evaluation of the efficacy of thyrotropin-releasing hormone analog","volume":"5","author":"Ohuchi","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.ejphar.2017.08.005_bib22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1155\/S1110724302203010","article-title":"Alzheimer disease and oxidative stress","volume":"2","author":"Perry","year":"2002","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ejphar.2017.08.005_bib23","doi-asserted-by":"crossref","first-page":"e39113","DOI":"10.1371\/journal.pone.0039113","article-title":"Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy","volume":"7","author":"Sareen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2017.08.005_bib24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2017.08.005_bib25","first-page":"s1793","article-title":"Preclinical studies of MCI-186, A novel free radical scavenger. studies on the concentrations of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in dog plasma and cerebral spinal fluid","volume":"25","author":"Takamatsu","year":"1997","journal-title":"Jpn J. Clin. Pharm. Ther."},{"key":"10.1016\/j.ejphar.2017.08.005_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/1531-8249(199907)46:1<129::AID-ANA21>3.0.CO;2-Y","article-title":"Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis","volume":"46","author":"Tohgi","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2017.08.005_bib27","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1128\/MCB.25.13.5543-5551.2005","article-title":"The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy","volume":"25","author":"Wan","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2017.08.005_bib28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.molcel.2008.06.004","article-title":"Inactivation of the SMN complex by oxidative stress","volume":"31","author":"Wan","year":"2008","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejphar.2017.08.005_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/cr.2012.166","article-title":"Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy","volume":"23","author":"Wang","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.ejphar.2017.08.005_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3999\/jscpt.28.693","article-title":"A pharmacokinetic study of MCI-186, a novel drug for cerebrovascular disease in elderly and young healthy subjects","volume":"28","author":"Yokota","year":"1997","journal-title":"Jpn. J. Clin. Pharm. Ther."},{"key":"10.1016\/j.ejphar.2017.08.005_bib31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/17482960600881870","article-title":"Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study)","volume":"7","author":"Yoshino","year":"2006","journal-title":"Amyotroph. Lateral Scler."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917305095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299917305095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T12:28:41Z","timestamp":1575376121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299917305095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":31,"alternative-id":["S0014299917305095"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.08.005","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells-derived disease model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2017.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}